HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: GID8 (Q9NWU2)
Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)
Gene: GID8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31617661, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 228
+	Hs
		203976 HTRA2_HUMAN (1-458): 0: 528: 100.00		MAEA_HUMAN (24-227): 1.88e-50: 170: 21.80
+	Hs
		204058 HTRA2_HUMAN (1-458): 0: 528: 100.00		RMD5A_HUMAN (25-206): 3.39e-48: 164: 17.65
+	Hs
		949088 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		MAEA_HUMAN (24-227): 1.88e-50: 170: 21.80
+	Hs
		203968 HTRA2_HUMAN (1-458): 0: 528: 100.00		RBP10_HUMAN (114-202): 8.7e-15: 74.7: 24.21