HitPredict

Interactor 1: B2L11 (O43521)
Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
Gene: BCL2L11

Interactor 2: MCL1 (Q07820)
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Gene: MCL1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 17097560, 26186194, 27013495, 20836993, 28514442, 15694340, 10837489, 33961781, 9731710, 19150432, 15721256, 16697956, 26045051, 19483105, 34667112, 27701804, 20074640, 21613222, 19622586, 19148187 and 11 others

more...
Identification Methods affinity chromatography technology, two hybrid, unspecified method, pull down, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, anti bait coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~Bclx_interact
Common GO terms GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 - regulation of apoptotic process
and 3 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 198
Hs

1 350
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Rn
+ Rn
+ Rn
+ Mm
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024