Protein: CHD6
Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)

Gene: CHD6
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q8TD26

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001221 - transcription coregulator binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396572

ESR1
Estrogen receptor

3

20

Small-scale

0.633

High

231154

AIRE
Autoimmune regulator

1

19

Small-scale

0.618

High

883621

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

980029

H4
Histone H4

1

12

High-throughput

0.618

High

980945

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998575

H31
Histone H3.1

1

20

High-throughput

0.618

High

1047923

TLE2
Transducin-like enhancer protein 2

1

11

High-throughput

0.618

High

1048041

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.618

High

1338859

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1350646

FBXW7
F-box/WD repeat-containing protein 7

1

9

Small-scale

0.618

High

1350647

PF21A
PHD finger protein 21A

1

17

High-throughput

0.618

High

1220682

RN123
E3 ubiquitin-protein ligase RNF123

1

13

High-throughput

0.553

High

521394

ARAF
Serine/threonine-protein kinase A-Raf

1

9

High-throughput

0.541

High

943277

RBM11
Splicing regulator RBM11

1

12

High-throughput

0.541

High

872559

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

1350653

RGAP1
Rac GTPase-activating protein 1

1

4

High-throughput

0.536

High

1161954

H31T
Histone H3.1t

1

20

High-throughput

0.527

High

426542

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

1350648

CDCA5
Sororin

1

0

High-throughput

0.513

High

175132

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.489

High

505590

ATX1L
Ataxin-1-like

1

3

High-throughput

0.481

High

138237

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

143132

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

194278

R113A
E3 ubiquitin-protein ligase RNF113A

1

3

High-throughput

0.479

High

225069

TLX3
T-cell leukemia homeobox protein 3

1

15

High-throughput

0.479

High

226578

TLX2
T-cell leukemia homeobox protein 2

1

9

High-throughput

0.479

High

246801

KDM1A
Lysine-specific histone demethylase 1A

1

20

High-throughput

0.479

High

363600

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

404255

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

474143

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487558

PARP1
Poly [ADP-ribose] polymerase 1

1

18

High-throughput

0.479

High

508321

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

587153

ITF2
Transcription factor 4

1

3

Small-scale

0.479

High

662252

PAX7
Paired box protein Pax-7

1

9

High-throughput

0.479

High

662466

GATA2
Endothelial transcription factor GATA-2

1

13

High-throughput

0.479

High

685276

PAX6
Paired box protein Pax-6

1

8

High-throughput

0.479

High

764900

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

776104

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

799998

COIL
Coilin

1

7

High-throughput

0.479

High

837070

ELK3
ETS domain-containing protein Elk-3

1

10

High-throughput

0.479

High

879292

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

14

High-throughput

0.479

High

891687

GSK3B
Glycogen synthase kinase-3 beta

1

6

Small-scale

0.479

High

904954

MECP2
Methyl-CpG-binding protein 2

1

19

High-throughput

0.479

High

920133

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.479

High

944707

KLF3
Krueppel-like factor 3

1

18

High-throughput

0.479

High

979083

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

991647

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.479

High

1087883

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1121471

KEAP1
Kelch-like ECH-associated protein 1

1

2

Small-scale

0.479

High

1133547

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1155571

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1194233

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1276523

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1336610

PAPD5
Terminal nucleotidyltransferase 4B

1

2

High-throughput

0.479

High

1350645

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1350650

FEV
Protein FEV

1

7

High-throughput

0.479

High

1350651

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

4

High-throughput

0.479

High

1350655

VSX1
Visual system homeobox 1

1

11

High-throughput

0.479

High

1350656

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1350657

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

1350658

ASF1A
Histone chaperone ASF1A

1

8

High-throughput

0.479

High

1350659

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

1350660

KLF12
Krueppel-like factor 12

1

14

High-throughput

0.479

High

336128

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

4

High-throughput

0.464

High

402789

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

1213455

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

911318

IMA5
Importin subunit alpha-5

1

20

High-throughput

0.445

High

957978

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.437

High

1141810

EEA1
Early endosome antigen 1

1

16

High-throughput

0.437

High

1350654

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

4

Small-scale

0.437

High

109155

G4U4J3
Terminal nucleotidyltransferase 4B

1

2

High-throughput

0.407

High

1350652

TOLIP
Toll-interacting protein

1

0

High-throughput

0.282

High

1348920

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1350649

CI085
Uncharacterized protein C9orf85

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025