HitPredict

Interactor 1: PPIP1 (O43586)
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Gene: PSTPIP1

Interactor 2: PTN18 (Q99952)
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
Gene: PTPN18

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	9265651, 35152348, 9422760
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 460
+	Mm
		956955 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN18_MOUSE (1-460): 0: 634: 75.92
+	Hs
		1307332 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN18_HUMAN (1-460): 0: 663: 100.00
+	Mm
		1142213 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN18_MOUSE (1-460): 0: 634: 75.92
+	Mm
		665999 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN22_MOUSE (6-394): 3.01e-149: 446: 41.99
+	Hs
		207851 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN22_HUMAN (6-389): 2.21e-146: 439: 38.70
+	Hs
		207795 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Mm
		728826 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN12_MOUSE (4-421): 2.75e-134: 407: 35.55
+	Mm
		666001 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN22_MOUSE (6-394): 3.01e-149: 446: 41.99
+	Hs
		1333999 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN22_HUMAN (6-389): 2.21e-146: 439: 38.70
+	Hs
		983514 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Mm
		728830 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN12_MOUSE (4-421): 2.75e-134: 407: 35.55
+	Hs
		1078935 ITSN1_HUMAN (319-415): 5.56e-09: 60.5: 20.62		PTN22_HUMAN (6-389): 2.21e-146: 439: 38.70
+	Hs
		207769 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN1_HUMAN (54-290): 2.48e-44: 162: 37.14
+	Hs
		617105 FCHO2_HUMAN (2-385): 3.04e-54: 194: 18.50		PTPRG_HUMAN (4-316): 2.2e-57: 206: 24.77
+	Mm
		719322 ITSN1_MOUSE (340-415): 3.53e-09: 61.2: 25.00		PTN11_MOUSE (51-297): 6.26e-45: 167: 38.70