Protein: HECD3
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)

Gene: HECD3, HECTD3
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q5T447

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0016567 - protein ubiquitination
GO:0019905 - syntaxin binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048471 - perinuclear region of cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982202

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.845

High

1212627

UBQL1
Ubiquilin-1

1

17

High-throughput

0.665

High

144181

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.647

High

884345

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

20

Small-scale

0.647

High

957093

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1162670

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.647

High

1212560

HECD3
E3 ubiquitin-protein ligase HECTD3

1

15

Small-scale

0.647

High

1212596

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

3

Small-scale

0.647

High

1212565

MRM1
rRNA methyltransferase 1, mitochondrial

4

2

High-throughput

0.630

High

1212577

ZDH17
Palmitoyltransferase ZDHHC17

1

14

High-throughput

0.625

High

461577

HS90A
Heat shock protein HSP 90-alpha

2

19

Small-scale

0.624

High

1212603

ODAD4
Outer dynein arm-docking complex subunit 4

1

16

High-throughput

0.618

High

241927

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

856728

BAG6
Large proline-rich protein BAG6

1

20

Small-scale

0.618

High

1113322

CUL3
Cullin-3

1

15

High-throughput

0.618

High

1212576

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

15

High-throughput

0.618

High

569252

YJU2B
Probable splicing factor YJU2B

3

1

High-throughput

0.609

High

584103

FOSL2
Fos-related antigen 2

3

4

High-throughput

0.609

High

1179072

RSPO1
R-spondin-1

3

3

High-throughput

0.609

High

1212572

TM10C
tRNA methyltransferase 10 homolog C

3

1

High-throughput

0.609

High

1212612

PAR6B
Partitioning defective 6 homolog beta

3

9

High-throughput

0.609

High

167479

WNT9B
Protein Wnt-9b

3

5

High-throughput

0.599

High

977271

RS4X
Small ribosomal subunit protein eS4, X isoform

3

8

High-throughput

0.593

High

70896

ZBBX
Zinc finger B-box domain-containing protein 1

2

2

High-throughput

0.574

High

178678

ANGP2
Angiopoietin-2

2

2

High-throughput

0.574

High

288177

CLC3A
C-type lectin domain family 3 member A

2

1

High-throughput

0.574

High

377862

GAST
Gastrin [Cleaved into: Gastrin-71

2

1

High-throughput

0.574

High

425193

IPSP
Plasma serine protease inhibitor

2

2

High-throughput

0.574

High

1012519

RT34
Small ribosomal subunit protein mS34

2

2

High-throughput

0.574

High

1212567

CAVN1
Caveolae-associated protein 1

2

3

High-throughput

0.574

High

1212568

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1212574

LYZL2
Lysozyme-like protein 2

2

3

High-throughput

0.574

High

1212578

EGFL6
Epidermal growth factor-like protein 6

2

18

High-throughput

0.574

High

1212581

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.574

High

1212600

RT24
Small ribosomal subunit protein uS3m

2

2

High-throughput

0.574

High

1212607

GA2L1
GAS2-like protein 1

2

11

High-throughput

0.574

High

1212610

CRDL1
Chordin-like protein 1

2

6

High-throughput

0.574

High

1212615

WF10A
WAP four-disulfide core domain protein 10A

2

1

High-throughput

0.574

High

1212619

CSN7B
COP9 signalosome complex subunit 7b

2

7

High-throughput

0.574

High

342213

BRD1
Bromodomain-containing protein 1

2

10

High-throughput

0.558

High

1212586

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.558

High

1212587

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

2

High-throughput

0.558

High

1212605

ZN317
Zinc finger protein 317

2

5

High-throughput

0.558

High

1212630

XCT
Cystine/glutamate transporter

2

5

Small-scale

0.558

High

248718

PEPL
Periplakin

2

20

High-throughput

0.553

High

1212624

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

14

Small-scale

0.552

High

774773

TIMP3
Metalloproteinase inhibitor 3

2

1

High-throughput

0.549

High

1212590

FA81A
Protein FAM81A

2

1

High-throughput

0.549

High

1212597

PATE1
Prostate and testis expressed protein 1

2

1

High-throughput

0.549

High

1212618

GREM2
Gremlin-2

2

1

High-throughput

0.549

High

1212621

EMIL3
EMILIN-3

2

6

High-throughput

0.549

High

1212631

RT07
Small ribosomal subunit protein uS7m

2

10

High-throughput

0.549

High

1212616

TARA
TRIO and F-actin-binding protein

1

11

Small-scale

0.523

High

177888

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.512

High

400965

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.512

High

487402

PARP1
Poly [ADP-ribose] polymerase 1

1

10

Small-scale

0.512

High

936953

CASP9
Caspase-9

1

5

Small-scale

0.512

High

1132376

CASP8
Caspase-8

1

5

Small-scale

0.512

High

49565

FEZF1
Fez family zinc finger protein 1

1

16

High-throughput

0.489

High

61520

VWA8
von Willebrand factor A domain-containing protein 8

1

5

High-throughput

0.489

High

139064

LAD1
Ladinin-1

1

8

High-throughput

0.489

High

409581

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

6

High-throughput

0.489

High

610701

TCPA
T-complex protein 1 subunit alpha

1

18

High-throughput

0.489

High

626965

FST
Follistatin

1

1

High-throughput

0.489

High

644196

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

8

High-throughput

0.489

High

762135

CNR2
Cannabinoid receptor 2

1

10

Small-scale

0.489

High

821395

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.489

High

899423

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.489

High

944816

PCBP3
Poly(rC)-binding protein 3

1

20

High-throughput

0.489

High

1007061

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

1012855

RT09
Small ribosomal subunit protein uS9m

1

8

High-throughput

0.489

High

1124168

IL27B
Interleukin-27 subunit beta

1

10

High-throughput

0.489

High

1212564

ISK14
Serine protease inhibitor Kazal-type 14

1

1

High-throughput

0.489

High

1212566

PRR27
Proline-rich protein 27

1

14

High-throughput

0.489

High

1212573

MAVS
Mitochondrial antiviral-signaling protein

1

17

High-throughput

0.489

High

1212580

SULF2
Extracellular sulfatase Sulf-2

1

3

High-throughput

0.489

High

1212582

CBPA6
Carboxypeptidase A6

1

2

High-throughput

0.489

High

1212583

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.489

High

1212584

LRC17
Leucine-rich repeat-containing protein 17

1

3

High-throughput

0.489

High

1212589

G45IP
Large ribosomal subunit protein mL64

1

2

High-throughput

0.489

High

1212591

RM30
Large ribosomal subunit protein uL30m

1

2

High-throughput

0.489

High

1212595

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.489

High

1212598

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.489

High

1212606

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

1212608

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.489

High

1212609

OVOL2
Transcription factor Ovo-like 2

1

12

High-throughput

0.489

High

1212613

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.489

High

1212614

UBXN6
UBX domain-containing protein 6

1

5

High-throughput

0.489

High

1212623

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.489

High

1212626

MRM2
rRNA methyltransferase 2, mitochondrial

1

4

High-throughput

0.489

High

1212629

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.489

High

799193

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.481

High

170184

AURKA
Aurora kinase A

1

20

High-throughput

0.479

High

372241

MYC
Myc proto-oncogene protein

1

13

Small-scale

0.479

High

468473

HS90B
Heat shock protein HSP 90-beta

1

19

High-throughput

0.479

High

1026421

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1094908

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1212628

STX8
Syntaxin-8

1

2

Small-scale

0.479

High

538615

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

5

High-throughput

0.470

High

442353

GELS
Gelsolin

1

5

High-throughput

0.470

High

650219

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.470

High

1133878

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

9

High-throughput

0.470

High

413986

P53
Cellular tumor antigen p53

1

20

Small-scale

0.439

High

106076

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

404120

GCR
Glucocorticoid receptor

1

16

High-throughput

0.437

High

412061

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

613074

EGR1
Early growth response protein 1

1

17

High-throughput

0.437

High

703617

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.437

High

810153

RL3
Large ribosomal subunit protein uL3

1

9

High-throughput

0.437

High

905591

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.437

High

909280

CCNG1
Cyclin-G1

1

3

High-throughput

0.437

High

1057172

PRDX1
Peroxiredoxin-1

1

12

Small-scale

0.437

High

1106570

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.437

High

1135705

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.437

High

1153811

SMAD2
Mothers against decapentaplegic homolog 2

1

20

High-throughput

0.437

High

1158368

CDC37
Hsp90 co-chaperone Cdc37

1

2

Small-scale

0.437

High

1212569

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1212571

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

1212604

YI001
Uncharacterized protein FLJ30774

1

1

High-throughput

0.437

High

1212617

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1212620

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

1212622

DJC28
DnaJ homolog subfamily C member 28

1

1

High-throughput

0.437

High

1212625

ZRAN1
Ubiquitin thioesterase ZRANB1

1

17

High-throughput

0.437

High

95875

E7EPC3
Protein Wnt

1

5

High-throughput

0.407

High

133862

FOXN3
Forkhead box protein N3

1

6

High-throughput

0.407

High

171473

S27A2
Long-chain fatty acid transport protein 2

1

9

High-throughput

0.407

High

252077

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.407

High

437701

HEPS
Serine protease hepsin

1

3

High-throughput

0.407

High

894422

MMP14
Matrix metalloproteinase-14

1

4

High-throughput

0.407

High

1010048

DLK1
Protein delta homolog 1

1

19

High-throughput

0.407

High

1194781

GRPL2
GLIPR1-like protein 2

1

1

High-throughput

0.407

High

1199077

CTL4
Choline transporter-like protein 4

1

2

High-throughput

0.407

High

1207863

S27A3
Long-chain fatty acid transport protein 3

1

9

High-throughput

0.407

High

1212561

DIK1A
Divergent protein kinase domain 1A

1

1

High-throughput

0.407

High

1212562

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.407

High

1212563

ABLM2
Actin-binding LIM protein 2

1

10

High-throughput

0.407

High

1212575

RIC3
Protein RIC-3

1

2

High-throughput

0.407

High

1212579

ZN695
Zinc finger protein 695

1

3

High-throughput

0.407

High

1212585

CI163
Uncharacterized protein C9orf163

1

1

High-throughput

0.407

High

1212592

HUMMR
Protein MGARP

1

1

High-throughput

0.407

High

1212593

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.407

High

1212599

LPAR1
Lysophosphatidic acid receptor 1

1

11

High-throughput

0.407

High

1212602

MF14A
Hippocampus abundant transcript 1 protein

1

7

High-throughput

0.407

High

1212611

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

5

High-throughput

0.407

High

1212632

ZDHC9
Palmitoyltransferase ZDHHC9

1

5

High-throughput

0.407

High

1212594

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.279

Low

1212633

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1212601

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.249

Low

1212570

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1212588

NOA1
Nitric oxide-associated protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025