HitPredict

Interactor 1: PPIP1 (O43586)
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Gene: PSTPIP1

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.652

Property	Details
Experiments	35152348, 25040622
Identification Methods	fluorescence polarization spectroscopy, isothermal titration calorimetry, x-ray crystallography, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 807
+	Mm
		665999 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN22_MOUSE (1-807): 0: 1083: 70.53
+	Hs
		1333999 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN22_HUMAN (1-807): 0: 1129: 100.00
+	Mm
		666001 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN22_MOUSE (1-807): 0: 1083: 70.53
+	Hs
		1078935 ITSN1_HUMAN (319-415): 5.56e-09: 60.5: 20.62		PTN22_HUMAN (1-807): 0: 1129: 100.00
+	Hs
		207795 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Mm
		728826 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN12_MOUSE (1-696): 0: 692: 35.36
+	Hs
		983514 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Mm
		728830 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN12_MOUSE (1-696): 0: 692: 35.36
+	Hs
		207829 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN18_HUMAN (5-329): 1.57e-133: 406: 42.81
+	Mm
		956955 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN18_MOUSE (3-333): 8.01e-132: 401: 42.34
+	Hs
		1307332 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN18_HUMAN (5-329): 1.57e-133: 406: 42.81
+	Mm
		1142213 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN18_MOUSE (3-333): 8.01e-132: 401: 42.34
+	Hs
		617105 FCHO2_HUMAN (2-385): 3.04e-54: 194: 18.50		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Mm
		719322 ITSN1_MOUSE (340-415): 3.53e-09: 61.2: 25.00		PTN11_MOUSE (287-497): 2.12e-12: 72.5: 14.09