HitPredict

Interactor 1: SPY2 (O43597)
Protein sprouty homolog 2 (Spry-2)
Gene: SPRY2

Interactor 2: AQP1 (P29972)
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule)
Gene: AQP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 315 Hs			1 269
+	Hs
		208412 SPY3_HUMAN (39-305): 3.2e-89: 269: 44.89		AQP1_HUMAN (1-269): 3.35e-102: 300: 100.00
+	Hs
		670358 SPRE2_HUMAN (142-282): 3.12e-42: 152: 25.85		AQP1_HUMAN (1-269): 3.35e-102: 300: 100.00
+	Hs
		670359 SPRE1_HUMAN (142-277): 3.35e-39: 145: 25.18		AQP1_HUMAN (1-269): 3.35e-102: 300: 100.00