HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	29568343
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, PH~SH3_1, SH3_1~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 359
+	Hs
		269515 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00
+	Mm
		763391 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53
+	Hs
		269511 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00
+	Hs
		412249 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SKAP1_HUMAN (13-359): 1e-98: 298: 42.54
+	Hs
		557834 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		GAB2_HUMAN (115-331): 1.42e-27: 115: 14.41
+	Hs
		209111 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		SESQ1_HUMAN (116-232): 1.81e-20: 91.1: 20.17
+	Hs
		209180 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ABI2_HUMAN (283-356): 3.54e-19: 90.7: 31.08
+	Mm
		223016 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		ABI1_MOUSE (281-356): 2e-17: 85.3: 28.95
+	Hs
		557806 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ABI2_HUMAN (283-356): 3.54e-19: 90.7: 31.08
+	Hs
		3136 A0A0S2Z4D7_HUMAN (1-138): 6.51e-59: 190: 67.39		ABI2_HUMAN (283-356): 3.54e-19: 90.7: 31.08
+	Hs
		782825 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		1040322 GRAP_HUMAN (5-169): 7.3e-28: 110: 15.74		GAB2_HUMAN (115-331): 1.42e-27: 115: 14.41
+	Hs
		655468 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		412098 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53
+	Hs
		412353 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		655510 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		GAB2_HUMAN (115-331): 1.42e-27: 115: 14.41
+	Hs
		412147 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		BTK_HUMAN (122-358): 7.1e-28: 116: 12.69
+	Hs
		412426 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		CD2AP_HUMAN (225-359): 4.02e-22: 99.5: 22.54
+	Mm
		643107 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		ABI1_MOUSE (281-356): 2e-17: 85.3: 28.95
+	Hs
		1349275 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		ITSN2_HUMAN (234-358): 8.51e-12: 68.7: 20.80