Protein: CYB5B
Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)

Gene: CYB5B
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43169

Gene Ontology (top 5):
GO:0005741 - mitochondrial outer membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0006805 - xenobiotic metabolic process
GO:0006809 - nitric oxide biosynthetic process
GO:0006979 - response to oxidative stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208961

CD33
Myeloid cell surface antigen CD33

2

1

High-throughput

0.700

High

209043

BTNL9
Butyrophilin-like protein 9

2

0

High-throughput

0.655

High

209152

MTCH2
Mitochondrial carrier homolog 2

3

2

High-throughput

0.650

High

209038

MFSD5
Molybdate-anion transporter

3

0

High-throughput

0.620

High

208970

CEAM6
Cell adhesion molecule CEACAM6

1

2

High-throughput

0.618

High

208948

GCR
Glucocorticoid receptor

2

2

High-throughput

0.611

High

209000

CKAP4
Cytoskeleton-associated protein 4

2

1

High-throughput

0.611

High

209128

MTCH1
Mitochondrial carrier homolog 1

2

2

High-throughput

0.611

High

58658

FRMD3
FERM domain-containing protein 3

2

1

High-throughput

0.606

High

208965

STOM
Stomatin

2

1

High-throughput

0.606

High

208975

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

4

High-throughput

0.606

High

209018

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

1

High-throughput

0.606

High

209028

MF14B
Hippocampus abundant transcript-like protein 1

2

6

High-throughput

0.606

High

209029

MARH8
E3 ubiquitin-protein ligase MARCHF8

2

2

High-throughput

0.606

High

209036

PLPP4
Phospholipid phosphatase 4

2

1

High-throughput

0.606

High

209089

TM41A
Transmembrane protein 41A

2

1

High-throughput

0.606

High

209110

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.606

High

209150

FLVC1
Choline/ethanolamine transporter FLVCR1

2

2

High-throughput

0.601

High

208945

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.586

High

208992

SC61B
Protein transport protein Sec61 subunit beta

2

3

High-throughput

0.584

High

208930

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

2

0

High-throughput

0.580

High

208937

KCNK5
Potassium channel subfamily K member 5

2

0

High-throughput

0.580

High

209026

NACHO
Novel acetylcholine receptor chaperone

2

0

High-throughput

0.580

High

209052

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.580

High

209055

TM139
Transmembrane protein 139

2

0

High-throughput

0.580

High

209067

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

209076

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.580

High

209091

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

209095

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

209099

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.580

High

209109

MFF
Mitochondrial fission factor

2

0

High-throughput

0.580

High

209080

CTL1
Choline transporter-like protein 1

2

0

High-throughput

0.576

High

208938

CXB5
Gap junction beta-5 protein

2

1

High-throughput

0.553

High

208956

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.553

High

208962

SYT1
Synaptotagmin-1

2

1

High-throughput

0.553

High

209007

AQP6
Aquaporin-6

2

3

High-throughput

0.553

High

209020

STX1A
Syntaxin-1A

2

1

High-throughput

0.553

High

209023

SOAT
Sodium-dependent organic anion transporter

2

3

High-throughput

0.553

High

209027

F209A
Protein FAM209A

2

1

High-throughput

0.553

High

209031

MFS4B
Sodium-dependent glucose transporter 1

2

1

High-throughput

0.553

High

209078

GP152
Probable G-protein coupled receptor 152

2

13

High-throughput

0.553

High

209119

S39A9
Zinc transporter ZIP9

2

3

High-throughput

0.553

High

173631

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.536

High

208932

CLAP2
CLIP-associating protein 2

1

1

High-throughput

0.536

High

208939

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.536

High

208971

MTOR
Serine/threonine-protein kinase mTOR

1

3

High-throughput

0.536

High

208981

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

1

High-throughput

0.536

High

208988

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

208989

XPO2
Exportin-2

1

3

High-throughput

0.536

High

208999

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.536

High

209003

ATM
Serine-protein kinase ATM

1

2

High-throughput

0.536

High

209009

CKAP5
Cytoskeleton-associated protein 5

1

2

High-throughput

0.536

High

209016

CND1
Condensin complex subunit 1

1

1

High-throughput

0.536

High

209024

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

4

High-throughput

0.536

High

209035

ECM29
Proteasome adapter and scaffold protein ECM29

1

5

High-throughput

0.536

High

209041

NCEH1
Neutral cholesterol ester hydrolase 1

1

1

High-throughput

0.536

High

209070

F241A
Uncharacterized protein FAM241A

1

1

High-throughput

0.536

High

209074

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.536

High

209077

CIP2A
Protein CIP2A

1

1

High-throughput

0.536

High

209082

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.536

High

209093

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

1

High-throughput

0.536

High

209114

RTN4
Reticulon-4

1

3

High-throughput

0.536

High

209140

COG5
Conserved oligomeric Golgi complex subunit 5

1

1

High-throughput

0.536

High

209153

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

2

High-throughput

0.536

High

133149

QSOX1
Sulfhydryl oxidase 1

1

0

High-throughput

0.513

High

135413

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

177491

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

183109

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.513

High

208926

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

208931

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.513

High

208933

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

208978

TSC2
Tuberin

1

0

High-throughput

0.513

High

208987

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

208997

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

209010

ERG1
Squalene monooxygenase

1

0

High-throughput

0.513

High

209022

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.513

High

209040

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

209042

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.513

High

209046

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

209051

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

209058

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

209063

INT1
Integrator complex subunit 1

1

0

High-throughput

0.513

High

209072

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.513

High

209075

GOGA5
Golgin subfamily A member 5

1

0

High-throughput

0.513

High

209101

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

209127

GDE1
Glycerophosphodiester phosphodiesterase 1

1

0

High-throughput

0.513

High

209135

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.513

High

209138

TMCC3
Transmembrane and coiled-coil domain protein 3

1

0

High-throughput

0.513

High

208951

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

164491

TNPO2
Transportin-2

1

2

High-throughput

0.489

High

208929

ORC5
Origin recognition complex subunit 5

1

1

High-throughput

0.489

High

209008

ATR
Serine/threonine-protein kinase ATR

1

2

High-throughput

0.489

High

209017

P2RY6
P2Y purinoceptor 6

1

8

High-throughput

0.489

High

209021

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.489

High

209050

NOP9
Nucleolar protein 9

1

1

High-throughput

0.489

High

209087

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.489

High

209088

OTUL
Ubiquitin thioesterase otulin

1

3

High-throughput

0.489

High

209094

QKI
KH domain-containing RNA-binding protein QKI

1

1

High-throughput

0.489

High

209102

DCNL5
DCN1-like protein 5

1

1

High-throughput

0.489

High

209103

LST8
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.489

High

209104

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

209107

XPO4
Exportin-4

1

3

High-throughput

0.489

High

209117

HELLS
Lymphoid-specific helicase

1

3

High-throughput

0.489

High

209118

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

1

High-throughput

0.489

High

209136

IPO11
Importin-11

1

4

High-throughput

0.489

High

209137

XPO7
Exportin-7

1

4

High-throughput

0.489

High

209142

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.489

High

209143

PLAP
Phospholipase A-2-activating protein

1

1

High-throughput

0.489

High

209149

TNPO3
Transportin-3

1

2

High-throughput

0.489

High

208928

CREB3
Cyclic AMP-responsive element-binding protein 3

1

2

High-throughput

0.481

High

209144

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.481

High

173780

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

208942

NB5R3
NADH-cytochrome b5 reductase 3

1

2

High-throughput

0.479

High

208943

RASN
GTPase NRas

1

4

High-throughput

0.479

High

208944

RASK
GTPase KRas

1

4

High-throughput

0.479

High

208947

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

208949

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

208950

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

208952

RHOC
Rho-related GTP-binding protein RhoC

1

10

High-throughput

0.479

High

208955

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

208958

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

208974

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

208976

MK08
Mitogen-activated protein kinase 8

1

4

High-throughput

0.479

High

208979

EMD
Emerin

1

1

High-throughput

0.479

High

208983

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

208984

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

208990

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

208991

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.479

High

208993

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

208994

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

208995

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

208998

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.479

High

209015

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

209019

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

209030

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

209059

MIRO2
Mitochondrial Rho GTPase 2

1

15

High-throughput

0.479

High

209065

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

209083

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

209086

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

209097

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

209098

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

209108

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

209111

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

209123

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

209125

ELOV5
Very long chain fatty acid elongase 5

1

5

High-throughput

0.479

High

209133

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

209134

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

209146

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

209132

CLN8
Protein CLN8

1

0

Small-scale

0.460

High

208969

COIL
Coilin

1

0

High-throughput

0.458

High

208977

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

209001

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.458

High

209006

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

209069

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

209124

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

209129

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

209130

RRBP1
Ribosome-binding protein 1

1

0

High-throughput

0.458

High

178107

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.445

High

208957

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

208972

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.445

High

209012

MFS10
Major facilitator superfamily domain-containing protein 10

1

9

High-throughput

0.445

High

209060

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.445

High

209105

S19A3
Thiamine transporter 2

1

4

High-throughput

0.445

High

208946

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

208968

MOT8
Monocarboxylate transporter 8

1

4

High-throughput

0.439

High

209014

NTCP
Hepatic sodium/bile acid cotransporter

1

3

High-throughput

0.439

High

209115

S35C2
Solute carrier family 35 member C2

1

1

High-throughput

0.439

High

208927

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

208936

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.437

High

208941

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.437

High

208964

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

High-throughput

0.437

High

208982

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.437

High

208986

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

208996

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

209039

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

209045

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

209053

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.437

High

209071

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

209100

DUS9
Dual specificity protein phosphatase 9

1

2

High-throughput

0.437

High

209116

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.437

High

209120

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

209126

WSB2
WD repeat and SOCS box-containing protein 2

1

1

High-throughput

0.437

High

209147

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.437

High

209148

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.437

High

208973

SATT
Neutral amino acid transporter A

1

0

High-throughput

0.426

High

209068

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

208954

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.407

High

209048

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

2

High-throughput

0.407

High

209057

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

208940

CLD7
Claudin-7

2

0

High-throughput

0.316

High

208960

MUC1
Mucin-1

2

0

High-throughput

0.316

High

209002

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

209004

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

209033

SDHF4
Succinate dehydrogenase assembly factor 4, mitochondrial

2

0

High-throughput

0.316

High

209049

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

209056

AHNK2
Protein AHNAK2

2

0

High-throughput

0.316

High

209062

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

209092

PHAR3
Phosphatase and actin regulator 3

2

0

High-throughput

0.316

High

209131

TUTLA
Protein turtle homolog A

2

0

High-throughput

0.316

High

208985

CAV2
Caveolin-2

2

0

High-throughput

0.298

High

208935

UTP20
Small subunit processome component 20 homolog

1

0

High-throughput

0.279

Low

208980

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.279

Low

209005

TARB1
tRNA

1

0

High-throughput

0.279

Low

209011

PUM1
Pumilio homolog 1

1

0

High-throughput

0.279

Low

209013

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

209034

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

209044

THADA
tRNA

1

0

High-throughput

0.279

Low

209054

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

209064

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

209073

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

209079

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.279

Low

209081

ATRIP
ATR-interacting protein

1

0

High-throughput

0.279

Low

209084

SYMPK
Symplekin

1

0

High-throughput

0.279

Low

209085

GLMN
Glomulin

1

0

High-throughput

0.279

Low

209090

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.279

Low

209096

XPO6
Exportin-6

1

0

High-throughput

0.279

Low

209113

K1586
E3 SUMO-protein ligase KIAA1586

1

0

High-throughput

0.279

Low

209121

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.279

Low

209139

TIM
Protein timeless homolog

1

0

High-throughput

0.279

Low

209141

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.279

Low

209145

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

209151

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.251

Low

137564

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

208934

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

208953

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

208959

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

208963

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.249

Low

208966

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

208967

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

209025

MIDN
Midnolin

1

0

High-throughput

0.249

Low

209032

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.249

Low

209037

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

209047

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

209061

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

209066

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

209106

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

209112

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.249

Low

209122

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025