HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1114
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		209056 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43
+	Hs
		208970 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		208972 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		557701 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43
+	Hs
		337883 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383587 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		557625 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		209065 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		208993 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (636-1018): 2.33e-122: 397: 32.17
+	Hs
		209063 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		557644 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHB1_HUMAN (604-1031): 2.72e-110: 369: 28.51
+	Hs
		208982 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		KIT_HUMAN (702-1024): 6.85e-74: 266: 39.31
+	Hs
		557624 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		499225 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		KIT_HUMAN (702-1024): 6.85e-74: 266: 39.31