HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 33961781, 24287595
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0007165 - signal transduction GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 906
+	Hs
		557607 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610633 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		209046 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		223012 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Mm
		82738 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		B9EKI5_MOUSE (23-901): 0: 799: 47.22
+	Hs
		557678 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		610276 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610517 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610238 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		454799 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610546 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610640 GRAP_MOUSE (5-169): 2.87e-26: 106: 17.13		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610554 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		CBL_MOUSE (1-906): 0: 888: 91.59
+	Rn
		88780 P85A_RAT (163-379): 8.5e-24: 105: 16.14		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		1027627 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		655351 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		1112072 GRAP_MOUSE (5-169): 2.87e-26: 106: 17.13		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Rn
		1144046 FYN_RAT (7-137): 2.1e-23: 103: 20.30		CBLB_RAT (23-901): 0: 792: 46.98
+	Hs
		203208 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		257713 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		ANR17_HUMAN (410-903): 9.9e-09: 61.5: 11.51