HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	11240126
Identification Methods	pull down, two hybrid, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1865
+	Hs
		557689 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		412190 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Mm
		1141146 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		DOCK1_MOUSE (1-1865): 0: 2189: 96.46
+	Hs
		924565 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		522979 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		557736 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924868 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		655417 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		412257 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924695 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		523056 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		1078864 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Hs
		924698 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Hs
		496365 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		411960 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		411566 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496788 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496189 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		924760 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PRG4_HUMAN (1634-1856): 2.09e-09: 65.2: 13.39
+	Hs
		1056926 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		MDC1_HUMAN (1604-1861): 7.61e-10: 66.7: 16.67