Protein: CYB5
Cytochrome b5 (Microsomal cytochrome b5 type A) (MCB5)

Gene: CYB5, CYB5A
Organism: Homo sapiens
Interactions: 121
UniProt ID: P00167

Gene Ontology (top 5):
GO:0005741 - mitochondrial outer membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0019899 - enzyme binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

357928

BAP31
B-cell receptor-associated protein 31

4

3

High-throughput

0.691

High

321996

ENDD1
Endonuclease domain-containing 1 protein

3

0

High-throughput

0.634

High

357939

HSP7E
Heat shock 70 kDa protein 14

2

4

High-throughput

0.628

High

357985

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

1

High-throughput

0.628

High

357920

CEAM6
Cell adhesion molecule CEACAM6

1

2

High-throughput

0.618

High

357897

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

2

High-throughput

0.611

High

357898

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

3

High-throughput

0.611

High

357930

SC61B
Protein transport protein Sec61 subunit beta

2

3

High-throughput

0.611

High

357999

MTCH2
Mitochondrial carrier homolog 2

2

2

High-throughput

0.571

High

357963

CP2W1
Cytochrome P450 2W1

1

4

High-throughput

0.541

High

357914

CALX
Calnexin

1

1

High-throughput

0.536

High

357918

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

357925

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.536

High

357960

F241A
Uncharacterized protein FAM241A

1

1

High-throughput

0.536

High

357974

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

357982

RTN4
Reticulon-4

1

3

High-throughput

0.536

High

357932

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

255353

SNX2
Sorting nexin-2

1

0

High-throughput

0.513

High

357901

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

357904

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

357919

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

357944

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.513

High

357946

RHG15
Rho GTPase-activating protein 15

1

0

High-throughput

0.513

High

357947

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

357967

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

357983

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

357899

CP1A2
Cytochrome P450 1A2

1

7

Small-scale

0.501

High

357900

CP2E1
Cytochrome P450 2E1

1

6

Small-scale

0.501

High

357903

CP3A4
Cytochrome P450 3A4

1

4

Small-scale

0.501

High

357905

CP2D6
Cytochrome P450 2D6

1

6

Small-scale

0.501

High

357907

CP2A6
Cytochrome P450 2A6

1

5

Small-scale

0.501

High

357909

CP3A5
Cytochrome P450 3A5

1

4

Small-scale

0.501

High

357935

CYC
Cytochrome c

1

1

Small-scale

0.501

High

357937

CP4AB
Cytochrome P450 4A11

1

2

Small-scale

0.501

High

47296

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

301291

WFS1
Wolframin

1

0

High-throughput

0.493

High

357915

GRN
Progranulin

1

0

High-throughput

0.493

High

357917

CCR1
C-C chemokine receptor type 1

1

9

High-throughput

0.489

High

357977

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

357969

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.481

High

173825

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

357896

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.479

High

357912

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

High-throughput

0.479

High

357922

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

357924

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

357926

EMD
Emerin

1

1

High-throughput

0.479

High

357931

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

357938

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

357945

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

357953

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.479

High

357954

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.479

High

357961

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

357962

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

357965

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

357972

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

357976

DERL1
Derlin-1

1

1

High-throughput

0.479

High

357979

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

357981

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

357988

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

357989

ELOV5
Very long chain fatty acid elongase 5

1

5

High-throughput

0.479

High

357991

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

357996

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

357997

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.479

High

357995

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

357911

UD14
UDP-glucuronosyltransferase 1A4

1

0

High-throughput

0.460

High

357941

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

357968

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

357970

UIF
UAP56-interacting factor

1

0

High-throughput

0.458

High

357971

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

357980

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

357984

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

357990

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

142263

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

299009

FLOT1
Flotillin-1

1

2

High-throughput

0.445

High

357902

CATG
Cathepsin G

1

6

High-throughput

0.445

High

357906

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

357908

CAP7
Azurocidin

1

7

High-throughput

0.445

High

357923

BAG6
Large proline-rich protein BAG6

1

5

High-throughput

0.445

High

357943

FLOT2
Flotillin-2

1

2

High-throughput

0.445

High

357952

FRMD5
FERM domain-containing protein 5

1

1

High-throughput

0.445

High

357956

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

248525

O10H3
Olfactory receptor 10H3

1

2

High-throughput

0.437

High

357933

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

357936

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

357942

CUL4A
Cullin-4A

1

2

High-throughput

0.437

High

357950

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

357958

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

357987

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

357992

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.437

High

125122

LEG9
Galectin-9

1

0

High-throughput

0.426

High

231430

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.426

High

261034

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

357916

IL2RG
Cytokine receptor common subunit gamma

1

0

High-throughput

0.426

High

357927

S26A2
Sulfate transporter

1

0

High-throughput

0.426

High

357951

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.426

High

357986

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

357993

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

357913

CD27
CD27 antigen

1

3

High-throughput

0.407

High

357929

CCR9
C-C chemokine receptor type 9

1

8

High-throughput

0.407

High

357959

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

357966

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.407

High

357973

S1PR3
Sphingosine 1-phosphate receptor 3

1

4

High-throughput

0.407

High

85228

RBG10
Rab GTPase-activating protein 1-like, isoform 10

2

0

High-throughput

0.318

High

184097

RER1
Protein RER1

1

0

High-throughput

0.279

Low

357934

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

357949

SYPL2
Synaptophysin-like protein 2

1

0

High-throughput

0.279

Low

357994

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

357998

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

245843

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

357910

HNF1A
Hepatocyte nuclear factor 1-alpha

1

0

Small-scale

0.249

Low

357921

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

Small-scale

0.249

Low

357955

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

357957

S38A6
Solute carrier family 38 member 6

1

0

High-throughput

0.249

Low

217302

PROM1
Prominin-1

1

0

Small-scale

0.238

Low

183319

ZN185
Zinc finger protein 185

1

0

High-throughput

0.232

Low

330011

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

357940

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

357948

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.232

Low

357964

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

357975

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.232

Low

357978

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025