HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2, Guanylate_kin~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1190
+	Hs
		782833 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1126376 SH319_HUMAN (1-57): 2.18e-16: 82.8: 19.30		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1285211 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		782779 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		990858 SH319_HUMAN (1-57): 2.18e-16: 82.8: 19.30		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Mm
		223014 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		159139 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Hs
		557746 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		412128 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		403445 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		655344 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Hs
		129286 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Mm
		1141133 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		924466 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1143451 SH3K1_MOUSE (8-109): 3.82e-16: 82: 17.31		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		411698 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Mm
		411930 LCK_MOUSE (3-188): 2.6e-19: 91.4: 16.58		DLG1_MOUSE (1-513): 1.74e-44: 177: 16.44
+	Rn
		73322 SRC_RAT (6-153): 4.66e-20: 93.7: 17.33		PALS1_RAT (455-886): 1.97e-39: 159: 19.67
+	Hs
		1232491 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		411800 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77