Protein: LRP1
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]

Gene: LRP1
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q07954

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001540 - amyloid-beta binding
GO:0002265 - astrocyte activation involved in immune response
GO:0003723 - RNA binding
GO:0005041 - low-density lipoprotein particle receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720464

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

10

Small-scale

0.951

High

464441

TSP1
Thrombospondin-1

3

9

Small-scale

0.845

High

1060942

LOXL2
Lysyl oxidase homolog 2

2

2

High-throughput

0.811

High

366542

TPA
Tissue-type plasminogen activator

2

9

Small-scale

0.696

High

1060900

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

11

High-throughput

0.691

High

363178

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.685

High

387414

APOE
Apolipoprotein E

3

7

Small-scale

0.684

High

127062

APBB1
Amyloid beta precursor protein binding family B member 1

3

1

Small-scale

0.669

High

449517

LIPL
Lipoprotein lipase

3

7

Small-scale

0.655

High

421986

A4
Amyloid-beta precursor protein

3

13

Small-scale

0.650

High

366244

FA9
Coagulation factor IX

1

9

Small-scale

0.647

High

317449

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

2

1

High-throughput

0.628

High

332400

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

4

High-throughput

0.628

High

408034

TBB4A
Tubulin beta-4A chain

2

5

High-throughput

0.628

High

534974

BIP
Endoplasmic reticulum chaperone BiP

2

3

High-throughput

0.628

High

552210

ADT3
ADP/ATP translocase 3

2

4

High-throughput

0.628

High

996919

TBA4A
Tubulin alpha-4A chain

2

4

High-throughput

0.628

High

997297

TBB4B
Tubulin beta-4B chain

2

5

High-throughput

0.628

High

1038186

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

2

1

High-throughput

0.628

High

1060880

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

2

4

High-throughput

0.628

High

1060887

TBA1A
Tubulin alpha-1A chain

2

4

High-throughput

0.628

High

1060912

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

4

High-throughput

0.628

High

1060915

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

4

High-throughput

0.628

High

1060922

PAPD1
Poly(A) RNA polymerase, mitochondrial

2

1

High-throughput

0.628

High

1060931

NOCT
Nocturnin

2

1

High-throughput

0.628

High

711327

SHC1
SHC-transforming protein 1

2

12

Small-scale

0.624

High

286364

DAB1
Disabled homolog 1

2

20

Small-scale

0.622

High

249694

CUBN
Cubilin

1

6

Small-scale

0.618

High

376497

LDLR
Low-density lipoprotein receptor

1

13

High-throughput

0.618

High

1060863

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

5

Small-scale

0.618

High

1060935

NOTC3
Neurogenic locus notch homolog protein 3

1

9

Small-scale

0.618

High

1060938

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.609

High

1060894

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

1006053

DLG4
Disks large homolog 4

2

9

Small-scale

0.606

High

143833

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.602

High

642093

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

2

0

High-throughput

0.602

High

884628

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

981800

RL23
Large ribosomal subunit protein uL14

2

0

High-throughput

0.602

High

1060866

NPRL3
GATOR1 complex protein NPRL3

2

0

High-throughput

0.602

High

1060881

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

2

0

High-throughput

0.602

High

1060926

SENP1
Sentrin-specific protease 1

2

0

High-throughput

0.602

High

1060940

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

2

0

High-throughput

0.602

High

424596

PAI1
Plasminogen activator inhibitor 1

1

0

Small-scale

0.586

High

1060920

FBX6
F-box only protein 6

2

8

High-throughput

0.584

High

1060865

FOXF2
Forkhead box protein F2

2

6

High-throughput

0.574

High

1060869

TBB3
Tubulin beta-3 chain

2

5

High-throughput

0.574

High

1060872

TBB2A
Tubulin beta-2A chain

2

5

High-throughput

0.574

High

1060877

TBB8
Tubulin beta-8 chain

2

5

High-throughput

0.574

High

1060879

KMCP1
Kidney mitochondrial carrier protein 1

2

4

High-throughput

0.574

High

1060885

SAMD1
Sterile alpha motif domain-containing protein 1

2

1

High-throughput

0.574

High

1060905

LCOR
Ligand-dependent corepressor

2

2

High-throughput

0.574

High

1060917

MTG2
Mitochondrial ribosome-associated GTPase 2

2

4

High-throughput

0.574

High

1053650

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

Small-scale

0.561

High

1060886

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

723661

CALCR
Calcitonin receptor

1

0

Small-scale

0.537

High

1042612

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.537

High

125424

LEG9
Galectin-9

1

14

High-throughput

0.536

High

161980

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

2

High-throughput

0.536

High

252444

DIAP1
Protein diaphanous homolog 1

1

1

High-throughput

0.536

High

288936

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.536

High

413701

P53
Cellular tumor antigen p53

1

1

High-throughput

0.536

High

424863

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.536

High

1054280

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

1

High-throughput

0.536

High

1060873

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.536

High

1060903

RB39B
Ras-related protein Rab-39B

1

6

High-throughput

0.536

High

1060916

SMOC1
SPARC-related modular calcium-binding protein 1

1

2

High-throughput

0.536

High

161565

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.527

High

167598

GIPC1
PDZ domain-containing protein GIPC1

1

3

Small-scale

0.527

High

269761

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.527

High

1060868

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

20

Small-scale

0.527

High

407615

S100B
Protein S100-B

1

1

High-throughput

0.515

High

849150

KSYK
Tyrosine-protein kinase SYK

1

18

High-throughput

0.515

High

1060937

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.515

High

369668

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.514

High

547135

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.513

High

984085

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

1060862

TROP
Trophinin

1

0

High-throughput

0.513

High

1060890

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1060896

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

1

0

High-throughput

0.513

High

1060897

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.513

High

1060914

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

1060918

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

1060936

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

1060941

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.513

High

139700

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

4

High-throughput

0.508

High

555470

SKIL
Ski-like protein

1

2

High-throughput

0.508

High

1060888

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

1

Small-scale

0.504

High

376387

PDGFB
Platelet-derived growth factor subunit B

1

2

Small-scale

0.501

High

376946

NGF
Beta-nerve growth factor

1

3

Small-scale

0.501

High

461400

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

533652

CLUS
Clusterin

1

3

Small-scale

0.501

High

538303

LIPC
Hepatic triacylglycerol lipase

1

7

Small-scale

0.501

High

557255

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.501

High

1022153

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

1060874

SNX17
Sorting nexin-17

1

4

Small-scale

0.501

High

1060902

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.501

High

943232

RBM11
Splicing regulator RBM11

1

1

High-throughput

0.494

High

1060871

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.493

High

1060928

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

1060875

FCN2
Ficolin-2

1

9

Small-scale

0.489

High

327107

NXPH4
Neurexophilin-4

1

2

High-throughput

0.489

High

1024000

HXA4
Homeobox protein Hox-A4

1

2

High-throughput

0.489

High

1060864

FOXF1
Forkhead box protein F1

1

6

High-throughput

0.489

High

1060893

AN36B
Ankyrin repeat domain-containing protein 36B

1

9

High-throughput

0.489

High

1060909

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.489

High

1060910

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.489

High

1060913

TBB2B
Tubulin beta-2B chain

1

5

High-throughput

0.489

High

1060925

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.489

High

1060943

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.489

High

944378

SYJ2B
Synaptojanin-2-binding protein

1

17

Small-scale

0.481

High

172078

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

1

Small-scale

0.481

High

472675

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

Small-scale

0.481

High

1060882

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

1

Small-scale

0.481

High

1060889

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

7

Small-scale

0.481

High

1060908

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

1060923

SCN3A
Sodium channel protein type 3 subunit alpha

1

4

Small-scale

0.481

High

1060934

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.481

High

361576

FA8
Coagulation factor VIII

1

0

Small-scale

0.480

High

218097

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

241493

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

323341

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.479

High

481254

HMGB1
High mobility group protein B1

1

1

High-throughput

0.479

High

603254

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.479

High

697857

CALR
Calreticulin

1

7

Small-scale

0.479

High

698604

CALX
Calnexin

1

7

Small-scale

0.479

High

774312

BASI
Basigin

1

5

High-throughput

0.479

High

894410

MMP14
Matrix metalloproteinase-14

1

3

Small-scale

0.479

High

976224

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.479

High

1051996

CALD1
Caldesmon

1

1

High-throughput

0.479

High

1060870

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1060884

APOA5
Apolipoprotein A-V

1

7

Small-scale

0.479

High

1060901

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

1060906

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

1060907

RANB9
Ran-binding protein 9

1

4

Small-scale

0.479

High

1060929

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1060944

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

1060876

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

Small-scale

0.460

High

1060921

RIC8B
Chaperone Ric-8B

1

0

Small-scale

0.460

High

388622

C1QA
Complement C1q subcomponent subunit A

1

0

Small-scale

0.458

High

537037

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

966236

1433G
14-3-3 protein gamma

1

0

High-throughput

0.458

High

1045214

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1060892

AGRF4
Adhesion G protein-coupled receptor F4

1

0

High-throughput

0.458

High

1060933

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

634964

NTF3
Neurotrophin-3

1

3

Small-scale

0.457

High

660257

BDNF
Neurotrophic factor BDNF precursor form

1

3

Small-scale

0.457

High

757422

NTF4
Neurotrophin-4

1

3

Small-scale

0.457

High

1060927

GULP1
PTB domain-containing engulfment adapter protein 1

1

20

Small-scale

0.457

High

480773

LEG1
Galectin-1

1

14

High-throughput

0.445

High

482682

SPRC
SPARC

1

4

High-throughput

0.445

High

906263

GPC3
Glypican-3

1

1

High-throughput

0.445

High

948803

CD81
CD81 antigen

1

3

High-throughput

0.445

High

1060899

DDX12
Putative ATP-dependent DNA helicase DDX12

1

1

High-throughput

0.445

High

1060930

FBX2
F-box only protein 2

1

8

High-throughput

0.445

High

1060939

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

105814

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

342164

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

630778

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.437

High

640587

MK
Midkine

1

5

Small-scale

0.437

High

1004483

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

1060867

PDIA2
Protein disulfide-isomerase A2

1

6

Small-scale

0.437

High

1060904

CHFR
E3 ubiquitin-protein ligase CHFR

1

1

Small-scale

0.437

High

1060919

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.437

High

1060924

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

1060861

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.426

High

296115

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

2

0

High-throughput

0.328

High

1060878

ERFE
Erythroferrone

2

0

High-throughput

0.328

High

1060883

KCD18
BTB/POZ domain-containing protein KCTD18

2

0

High-throughput

0.328

High

1060895

HASP
Serine/threonine-protein kinase haspin

2

0

High-throughput

0.328

High

1060911

CQ080
Mitochondrial nucleoid-associated protein 1

2

0

High-throughput

0.328

High

1060932

INT6
Integrator complex subunit 6

2

0

High-throughput

0.328

High

539668

MBL2
Mannose-binding protein C

1

0

Small-scale

0.279

Low

963950

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.279

Low

1060891

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low

1060898

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.264

Low

292317

TCEA3
Transcription elongation factor A protein 3

1

0

High-throughput

0.249

Low

352118

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.249

Low

1016800

H33
Histone H3.3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025