HitPredict

Interactor 1: RGS10 (O43665)
Regulator of G-protein signaling 10 (RGS10)
Gene: RGS10

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9207071
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 354
+	Hs
		444692 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		207517 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		283183 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		391357 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		207507 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		444693 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		207505 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		283156 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		277782 RGS9_HUMAN (2-172): 1.77e-56: 189: 30.90		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		283160 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Mm
		579646 RGS14_MOUSE (21-175): 1.23e-55: 185: 45.22		GNAO_MOUSE (1-354): 1.59e-172: 485: 71.83
+	Dm
		592744 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAI_DROME (1-354): 1.9e-168: 475: 77.75
+	Bt
		221230 RGS9_BOVIN (2-172): 4.58e-57: 187: 30.34		GNAT1_BOVIN (1-354): 8.16e-169: 475: 67.80
+	Hs
		834946 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		670435 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Dm
		558483 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAO_DROME (1-354): 6.39e-166: 468: 69.01
+	Hs
		207511 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Hs
		580410 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		283162 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		170629 AXIN1_HUMAN (7-172): 6.4e-55: 187: 30.86		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23