HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: LMO4 (P61968)
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)
Gene: LMO4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	18330356, 32296183, 15231748, unassigned1304, 20211142
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005667 - transcription regulator complex GO:0030334 - regulation of cell migration GO:0031252 - cell leading edge GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 165
+	Hs
		210834 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (23-158): 3.95e-48: 160: 39.71
+	Mm
		223243 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN2_MOUSE (23-148): 3.99e-46: 149: 45.67
+	Mm
		223248 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (1-165): 1.95e-43: 143: 100.00
+	Hs
		210830 LDB2_HUMAN (1-373): 0: 677: 100.00		ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55
+	Mm
		223246 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (22-162): 3.73e-39: 137: 36.55
+	Hs
		210838 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (13-152): 4.29e-41: 136: 47.86
+	Mm
		223252 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO3_MOUSE (13-152): 4.29e-41: 136: 47.86
+	Hs
		210827 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN1_HUMAN (1-143): 1.92e-36: 125: 48.25
+	Mm
		223254 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (1-152): 3.72e-36: 124: 47.37
+	Hs
		210826 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN2_HUMAN (23-140): 7.68e-36: 123: 46.61
+	Hs
		210841 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX4_HUMAN (82-165): 1.58e-12: 65.8: 18.75
+	Mm
		223245 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (82-165): 1.51e-12: 65.8: 18.75
+	Mm
		223247 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (12-77): 2.29e-11: 62.7: 23.88
+	Mm
		223242 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (12-80): 8.65e-11: 60.8: 30.00
+	Mm
		223259 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (14-82): 1.3e-10: 60.4: 30.00
+	Mm
		223262 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (87-165): 1.17e-10: 60.4: 17.39
+	Mm
		223249 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (12-77): 4.57e-10: 58.9: 23.88
+	Mm
		223263 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (15-85): 1e-09: 57.7: 25.00
+	Mm
		223255 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (76-152): 3.94e-09: 56.2: 16.88
+	Hs
		238112 LDB1_HUMAN (8-373): 0: 610: 76.84		LMX1B_HUMAN (12-80): 8.72e-11: 60.8: 30.00