Protein: CSN3
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)

Gene: CSN3, COPS3
Organism: Homo sapiens
Interactions: 213
UniProt ID: Q9UNS2

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0001701 - in utero embryonic development
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1406139

CSN8
COP9 signalosome complex subunit 8

17

6

Small-scale

0.986

High

958737

CSN2
COP9 signalosome complex subunit 2

17

18

Small-scale

0.985

High

1094443

CSN1
COP9 signalosome complex subunit 1

17

20

Small-scale

0.985

High

1272594

CSN6
COP9 signalosome complex subunit 6

13

20

Small-scale

0.982

High

1458847

CSN7A
COP9 signalosome complex subunit 7a

14

18

Small-scale

0.981

High

1413217

CSN4
COP9 signalosome complex subunit 4

11

18

Small-scale

0.976

High

1437206

CSN7B
COP9 signalosome complex subunit 7b

11

18

Small-scale

0.975

High

1462386

CSN3
COP9 signalosome complex subunit 3

2

17

Small-scale

0.768

High

1370467

CSN5
COP9 signalosome complex subunit 5

17

20

Small-scale

0.764

High

1115485

CUL4B
Cullin-4B

12

20

Small-scale

0.758

High

1115147

CUL4A
Cullin-4A

11

20

Small-scale

0.755

High

1114659

CUL3
Cullin-3

11

20

Small-scale

0.754

High

1157994

DDB1
DNA damage-binding protein 1

8

3

Small-scale

0.747

High

1113026

CUL2
Cullin-2

7

20

Small-scale

0.745

High

1360287

CSN9
COP9 signalosome complex subunit 9

6

3

Small-scale

0.737

High

1363107

DDB2
DNA damage-binding protein 2

6

8

Small-scale

0.729

High

1098386

ERCC8
DNA excision repair protein ERCC-8

6

7

Small-scale

0.728

High

1154479

STK11
Serine/threonine-protein kinase STK11

5

4

High-throughput

0.720

High

1352283

DCA11
DDB1- and CUL4-associated factor 11

5

4

High-throughput

0.712

High

1396704

LLR1
Leucine-rich repeat protein 1

5

2

High-throughput

0.712

High

1416615

BTBD2
BTB/POZ domain-containing protein 2

5

20

High-throughput

0.712

High

1112796

CUL1
Cullin-1

5

20

Small-scale

0.709

High

1429769

BTBD1
BTB/POZ domain-containing protein 1

4

20

High-throughput

0.694

High

1357607

DCAF4
DDB1- and CUL4-associated factor 4

4

5

High-throughput

0.691

High

1366004

APBP2
Amyloid protein-binding protein 2

4

3

High-throughput

0.691

High

1460936

FEM1B
Protein fem-1 homolog B

4

2

High-throughput

0.691

High

1462391

DCAF1
DDB1- and CUL4-associated factor 1

4

5

Small-scale

0.676

High

1235395

KLH10
Kelch-like protein 10

3

17

High-throughput

0.662

High

1462390

FBX7
F-box only protein 7

3

3

High-throughput

0.662

High

1371897

CUL5
Cullin-5

3

20

High-throughput

0.656

High

1139898

LRC14
Leucine-rich repeat-containing protein 14

3

4

High-throughput

0.650

High

1388935

FBX17
F-box only protein 17

3

6

High-throughput

0.650

High

999428

HBB
Hemoglobin subunit beta

3

0

High-throughput

0.638

High

342412

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

3

High-throughput

0.628

High

1272689

DET1
DET1 homolog

2

2

High-throughput

0.628

High

1323402

FXL14
F-box/LRR-repeat protein 14

2

3

High-throughput

0.628

High

1460976

FBXL5
F-box/LRR-repeat protein 5

2

1

High-throughput

0.628

High

844098

HD
Huntingtin

2

2

High-throughput

0.621

High

167999

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

7

Small-scale

0.620

High

320842

KLH18
Kelch-like protein 18

2

17

High-throughput

0.611

High

957554

UBC12
NEDD8-conjugating enzyme Ubc12

2

6

High-throughput

0.611

High

1154963

NEDD8
Ubiquitin-like protein NEDD8

2

5

Small-scale

0.611

High

1391974

DCNL1
DCN1-like protein 1

2

2

Small-scale

0.611

High

1397886

KLH15
Kelch-like protein 15

2

20

High-throughput

0.611

High

1448325

FBX6
F-box only protein 6

2

6

High-throughput

0.611

High

612331

ARF4
ADP-ribosylation factor 4

2

3

High-throughput

0.606

High

1383216

SOSB2
SOSS complex subunit B2

2

1

High-throughput

0.606

High

243294

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.601

High

386367

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.601

High

1060704

SOS1
Son of sevenless homolog 1

1

1

Small-scale

0.586

High

165783

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

2

0

High-throughput

0.585

High

984026

RBX1
E3 ubiquitin-protein ligase RBX1

2

3

High-throughput

0.584

High

1042943

ERCC6
DNA excision repair protein ERCC-6

2

3

Small-scale

0.584

High

1147308

ELOB
Elongin-B

2

2

High-throughput

0.584

High

1403151

CRBN
Protein cereblon

2

2

Small-scale

0.584

High

1415910

DDA1
DET1- and DDB1-associated protein 1

2

2

Small-scale

0.584

High

1453340

DTL
Denticleless protein homolog

2

9

Small-scale

0.584

High

220319

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.580

High

1235635

K2C80
Keratin, type II cytoskeletal 80

2

0

High-throughput

0.580

High

1338817

FAD1
FAD synthase

2

0

High-throughput

0.580

High

1348832

PXL2B
Prostamide/prostaglandin F synthase

2

0

High-throughput

0.580

High

1437621

NJMU
Protein Njmu-R1

2

0

High-throughput

0.580

High

401703

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

Small-scale

0.576

High

935294

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.571

High

1215386

DCAF8
DDB1- and CUL4-associated factor 8

2

14

High-throughput

0.571

High

1454691

KLH42
Kelch-like protein 42

2

20

High-throughput

0.571

High

1110892

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.561

High

1291379

LCA5
Lebercilin

2

0

High-throughput

0.547

High

220722

DENR
Density-regulated protein

1

2

High-throughput

0.536

High

530584

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

571642

IRF2
Interferon regulatory factor 2

1

5

High-throughput

0.536

High

867516

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

872890

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

1007618

PRAME
Melanoma antigen preferentially expressed in tumors

1

4

High-throughput

0.536

High

1111365

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1150503

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

High-throughput

0.536

High

1202262

DCAF6
DDB1- and CUL4-associated factor 6

1

13

High-throughput

0.536

High

1229885

CYTSA
Cytospin-A

1

2

High-throughput

0.536

High

1327621

WDTC1
WD and tetratricopeptide repeats protein 1

1

12

High-throughput

0.536

High

1402535

NEB2
Neurabin-2

1

1

High-throughput

0.536

High

1410289

KLDC3
Kelch domain-containing protein 3

1

18

High-throughput

0.536

High

1450097

AP5S1
AP-5 complex subunit sigma-1

1

1

High-throughput

0.536

High

1451558

ASB6
Ankyrin repeat and SOCS box protein 6

1

2

High-throughput

0.536

High

1454595

KLHL8
Kelch-like protein 8

1

17

High-throughput

0.536

High

155136

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

770789

PGH2
Prostaglandin G/H synthase 2

1

1

Small-scale

0.515

High

1454838

WRP73
WD repeat-containing protein WRAP73

1

4

High-throughput

0.515

High

160781

TOR1A
Torsin-1A

1

5

High-throughput

0.515

High

231783

PEX1
Peroxisomal ATPase PEX1

1

7

High-throughput

0.515

High

488572

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

9

High-throughput

0.515

High

703254

HXD10
Homeobox protein Hox-D10

1

1

High-throughput

0.515

High

713140

NOS3
Nitric oxide synthase 3

1

3

High-throughput

0.515

High

791841

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

901682

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.515

High

929848

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

1156367

SYUB
Beta-synuclein

1

2

High-throughput

0.515

High

1199405

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.515

High

1235106

TTBK2
Tau-tubulin kinase 2

1

2

High-throughput

0.515

High

1458200

ATX10
Ataxin-10

1

1

High-throughput

0.515

High

1462389

RNF11
RING finger protein 11

1

5

High-throughput

0.515

High

63064

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

213004

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

1350501

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.513

High

1453534

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.513

High

1462388

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

521462

ARAF
Serine/threonine-protein kinase A-Raf

1

3

Small-scale

0.508

High

1462394

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.506

High

1462387

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

1

Small-scale

0.506

High

508837

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

High-throughput

0.501

High

615248

IL1RA
Interleukin-1 receptor antagonist protein

1

1

Small-scale

0.501

High

998109

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.501

High

415937

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

479614

DOPO
Dopamine beta-hydroxylase

1

0

High-throughput

0.493

High

686662

ELAV4
ELAV-like protein 4

1

0

High-throughput

0.493

High

705608

GRN
Progranulin

1

0

High-throughput

0.493

High

767377

MERL
Merlin

1

0

High-throughput

0.493

High

833390

PERI
Peripherin

1

0

High-throughput

0.493

High

834379

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.493

High

852138

ACY2
Aspartoacylase

1

0

High-throughput

0.493

High

876223

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.493

High

905290

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.493

High

1123874

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.493

High

1277830

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.493

High

1419472

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.493

High

1200344

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1331880

SYT2
Synaptotagmin-2

1

2

High-throughput

0.489

High

1152997

CEBPE
CCAAT/enhancer-binding protein epsilon

1

6

Small-scale

0.481

High

995350

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.480

High

177963

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.479

High

214067

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.479

High

279538

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

316166

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

320148

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

373498

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

462048

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

538122

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

590033

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

623593

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.479

High

683538

IKBA
NF-kappa-B inhibitor alpha

1

4

Small-scale

0.479

High

696864

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

765122

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

769514

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

831650

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

945602

FBXW4
F-box/WD repeat-containing protein 4

1

7

Small-scale

0.479

High

946223

MLF1
Myeloid leukemia factor 1

1

3

Small-scale

0.479

High

967607

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

992397

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

1033313

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1049212

RON
Macrophage-stimulating protein receptor

1

2

High-throughput

0.479

High

1107335

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1135857

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1147148

ELOC
Elongin-C

1

1

High-throughput

0.479

High

1229768

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1256100

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1258418

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

1280603

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1335070

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1338435

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1340840

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.479

High

1359727

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

1364693

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1367593

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1368418

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

1380687

FBX32
F-box only protein 32

1

4

High-throughput

0.479

High

1401451

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1420907

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

High-throughput

0.479

High

1421008

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1421278

KLHL4
Kelch-like protein 4

1

19

High-throughput

0.479

High

1433242

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

Small-scale

0.479

High

1434235

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1438736

CPAP
Centrosomal P4.1-associated protein

1

1

High-throughput

0.479

High

1454480

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

Small-scale

0.479

High

1459316

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1462392

MAFB
Transcription factor MafB

1

9

High-throughput

0.479

High

1327273

FBXL6
F-box/LRR-repeat protein 6

1

7

High-throughput

0.470

High

1337556

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

567523

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

788818

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

1126788

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1218697

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

318914

RHBT1
Rho-related BTB domain-containing protein 1

1

14

High-throughput

0.445

High

430509

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

872050

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.445

High

1006182

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

2

High-throughput

0.445

High

1136958

ABRX2
BRISC complex subunit Abraxas 2

1

4

Small-scale

0.445

High

1199055

KLH12
Kelch-like protein 12

1

17

High-throughput

0.445

High

1209801

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1235030

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1419433

RHBT2
Rho-related BTB domain-containing protein 2

1

14

High-throughput

0.445

High

1454751

KLH13
Kelch-like protein 13

1

20

High-throughput

0.445

High

192519

INSI1
Insulin-induced gene 1 protein

1

2

High-throughput

0.437

High

353629

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

380190

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

412811

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

1241984

FBX42
F-box only protein 42

1

7

High-throughput

0.437

High

1332554

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

5

Small-scale

0.437

High

1433289

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

1

High-throughput

0.437

High

1462393

INSI2
Insulin-induced gene 2 protein

1

2

High-throughput

0.437

High

1349350

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.426

High

1452008

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.426

High

887334

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

62611

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

1253211

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

1

High-throughput

0.407

High

1271426

KCTD9
BTB/POZ domain-containing protein KCTD9

1

6

High-throughput

0.407

High

424109

ITB2
Integrin beta-2

1

0

Small-scale

0.288

High

369781

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.268

Low

389898

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

458944

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

622300

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1391532

BSCL2
Seipin

1

0

High-throughput

0.268

Low

517327

GOG8G
Golgin subfamily A member 8G

1

0

High-throughput

0.232

Low

1395430

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025