HitPredict

Interactor 1: BUB1 (O43683)
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)
Gene: BUB1

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	16189514, 35044719
Identification Methods	two hybrid, unspecified method, phage display, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1085 Hs			1 304
+	Hs
		236948 BUB1B_HUMAN (2-1078): 1.02e-166: 521: 19.02		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		581013 PKN2_HUMAN (217-1078): 8.14e-133: 429: 10.42		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924597 MYLK_HUMAN (135-1084): 2.2e-127: 430: 12.51		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		1039093 KCC2D_HUMAN (774-1085): 1.18e-103: 336: 14.29		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		209064 PKN2_HUMAN (217-1078): 8.14e-133: 429: 10.42		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557704 MYLK_HUMAN (135-1084): 2.2e-127: 430: 12.51		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		557706 PKN2_HUMAN (217-1078): 8.14e-133: 429: 10.42		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		924549 KCC2D_HUMAN (774-1085): 1.18e-103: 336: 14.29		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		580997 PAK1_HUMAN (584-1085): 3.96e-95: 315: 16.97		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924536 PAK1_HUMAN (584-1085): 3.96e-95: 315: 16.97		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924538 PAK2_HUMAN (581-1085): 4.98e-84: 284: 15.37		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209044 PAK1_HUMAN (584-1085): 3.96e-95: 315: 16.97		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557676 PAK1_HUMAN (584-1085): 3.96e-95: 315: 16.97		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		1026202 PAK1_HUMAN (584-1085): 3.96e-95: 315: 16.97		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Mm
		292046 PAK1_MOUSE (584-1084): 2.94e-93: 310: 15.71		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00
+	Hs
		209045 PAK2_HUMAN (581-1085): 4.98e-84: 284: 15.37		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557677 PAK2_HUMAN (581-1085): 4.98e-84: 284: 15.37		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		1026936 PAK2_HUMAN (581-1085): 4.98e-84: 284: 15.37		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		277595 PAK3_HUMAN (584-1085): 1.72e-82: 281: 14.16		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		277606 PAK3_HUMAN (584-1085): 1.72e-82: 281: 14.16		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87