Protein: ARHGC
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)

Gene: ARHGC, ARHGEF12
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q9NZN5

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962568

RHOA
Transforming protein RhoA

9

20

Small-scale

0.971

High

167658

GIPC1
PDZ domain-containing protein GIPC1

5

4

High-throughput

0.935

High

466498

RHOC
Rho-related GTP-binding protein RhoC

3

20

High-throughput

0.861

High

177408

ARHGB
Rho guanine nucleotide exchange factor 11

3

16

High-throughput

0.839

High

1125940

GNA13
Guanine nucleotide-binding protein subunit alpha-13

3

14

Small-scale

0.827

High

1400318

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

19

High-throughput

0.767

High

978359

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1453489

VAPA
Vesicle-associated membrane protein-associated protein A

7

3

High-throughput

0.747

High

1357434

DEP1B
DEP domain-containing protein 1B

2

9

High-throughput

0.737

High

1453494

MYO6
Unconventional myosin-VI

5

9

Small-scale

0.723

High

333238

VAPB
Vesicle-associated membrane protein-associated protein B/C

5

3

High-throughput

0.716

High

522748

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

Small-scale

0.713

High

1447366

ANLN
Anillin

1

5

High-throughput

0.691

High

1453490

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.678

High

1114492

CUL3
Cullin-3

3

11

Small-scale

0.669

High

840898

TEC
Tyrosine-protein kinase Tec

1

18

Small-scale

0.647

High

893536

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

13

Small-scale

0.618

High

953715

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955688

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

1040981

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

14

Small-scale

0.618

High

1255867

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

1353108

ARH40
Rho guanine nucleotide exchange factor 40

1

18

High-throughput

0.618

High

1353630

GIPC2
PDZ domain-containing protein GIPC2

1

4

High-throughput

0.618

High

1434089

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

1453488

ARHGC
Rho guanine nucleotide exchange factor 12

1

16

Small-scale

0.618

High

908180

KS6A3
Ribosomal protein S6 kinase alpha-3

2

8

High-throughput

0.611

High

1213046

CC183
Coiled-coil domain-containing protein 183

3

9

High-throughput

0.609

High

1328451

S2541
Mitochondrial carrier protein SCaMC-3L

3

2

High-throughput

0.609

High

1391111

TRM61
tRNA

3

1

High-throughput

0.609

High

465672

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.594

High

397096

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

591385

CD44
CD44 antigen

1

2

Small-scale

0.561

High

208139

PLXB1
Plexin-B1

1

15

Small-scale

0.552

High

211065

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

277419

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.536

High

281439

GGYF1
GRB10-interacting GYF protein 1

1

7

High-throughput

0.536

High

451084

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.536

High

732725

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

821215

TXLNA
Alpha-taxilin

1

7

High-throughput

0.536

High

1330304

KC1AL
Casein kinase I isoform alpha-like

1

7

High-throughput

0.536

High

1383880

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1420243

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1453497

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.536

High

485476

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.515

High

778796

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

1136608

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

1389029

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1453495

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

363944

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.501

High

1453498

KLH20
Kelch-like protein 20

1

5

Small-scale

0.501

High

175444

PLXB2
Plexin-B2

1

16

Small-scale

0.479

High

299403

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

338022

ABCA1
Phospholipid-transporting ATPase ABCA1

1

1

Small-scale

0.479

High

437370

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

459776

PROF1
Profilin-1

1

5

High-throughput

0.479

High

552714

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

556381

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

582995

EZRI
Ezrin

1

9

High-throughput

0.479

High

643106

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

651446

CBL
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.479

High

878572

PAXI
Paxillin

1

9

High-throughput

0.479

High

891336

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

891836

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.479

High

896647

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.479

High

1048737

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1097070

PRDX4
Peroxiredoxin-4

1

5

High-throughput

0.479

High

1431553

VP33B
Vacuolar protein sorting-associated protein 33B

1

5

High-throughput

0.479

High

1431666

GAN
Gigaxonin

1

7

High-throughput

0.479

High

1452565

BCLF1
Bcl-2-associated transcription factor 1

1

2

High-throughput

0.479

High

1453491

ANFY1
Rabankyrin-5

1

10

High-throughput

0.479

High

1453492

XPO7
Exportin-7

1

15

High-throughput

0.479

High

1453493

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1062686

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

1110748

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1446978

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

889515

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.457

High

963473

STXB1
Syntaxin-binding protein 1

1

5

High-throughput

0.457

High

516374

CALM1
Calmodulin-1

1

2

High-throughput

0.445

High

516454

CALM2
Calmodulin-2

1

2

High-throughput

0.445

High

516597

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

1119339

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

106759

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

290769

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.437

High

412718

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

1159877

OCLN
Occludin

1

2

High-throughput

0.437

High

1367445

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

954752

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1148400

KS6A1
Ribosomal protein S6 kinase alpha-1

1

11

Small-scale

0.408

High

1086713

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

1388111

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1394293

DYDC2
DPY30 domain-containing protein 2

1

0

High-throughput

0.279

Low

1408103

SSX3
Protein SSX3

1

0

High-throughput

0.279

Low

1409613

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1453499

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.279

Low

1256932

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1453496

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025