HitPredict

Interactor 1: BUB1 (O43683)
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)
Gene: BUB1

Interactor 2: CDC16 (Q13042)
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)
Gene: CDC16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1085 Hs			1 620
+	Hs
		236919 BUB1B_HUMAN (2-1078): 1.02e-166: 521: 19.02		CDC16_HUMAN (1-620): 1.68e-124: 382: 100.00
+	Hs
		160541 AURKA_HUMAN (654-1065): 8.12e-81: 271: 15.09		CDC16_HUMAN (1-620): 1.68e-124: 382: 100.00
+	Hs
		236988 BUB1B_HUMAN (2-1078): 1.02e-166: 521: 19.02		APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73
+	Hs
		236987 BUB1B_HUMAN (2-1078): 1.02e-166: 521: 19.02		CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71
+	Hs
		236886 BUB1B_HUMAN (2-1078): 1.02e-166: 521: 19.02		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80
+	Hs
		174520 LATS1_HUMAN (111-1077): 6.55e-119: 395: 10.17		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Hs
		166626 DCLK1_HUMAN (396-1075): 1.55e-121: 392: 12.97		CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71
+	Sp
		223612 MAD3_SCHPO (4-195): 8.93e-65: 223: 28.78		CUT9_SCHPO (3-598): 2.2e-72: 247: 31.33
+	Hs
		174862 KCC2D_HUMAN (774-1085): 1.18e-103: 336: 14.29		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Hs
		174843 PAK2_HUMAN (581-1085): 4.98e-84: 284: 15.37		OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67
+	Hs
		160839 AURKA_HUMAN (654-1065): 8.12e-81: 271: 15.09		APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73
+	Sp
		223611 MAD3_SCHPO (4-195): 8.93e-65: 223: 28.78		APC3_SCHPO (4-578): 2.69e-33: 137: 12.04
+	Hs
		160838 AURKA_HUMAN (654-1065): 8.12e-81: 271: 15.09		CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71
+	Hs
		160401 AURKA_HUMAN (654-1065): 8.12e-81: 271: 15.09		CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80
+	Dm
		51410 A1Z6I7_DROME (4-319): 1.92e-66: 247: 24.56		Q9VS37_DROME (337-585): 4.17e-15: 81: 14.45
+	Sp
		223608 MAD3_SCHPO (4-195): 8.93e-65: 223: 28.78		APC8_SCHPO (3-180): 1.31e-09: 62.9: 11.46