Protein: TP4A3
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)

Gene: TP4A3, PTP4A3
Organism: Homo sapiens
Interactions: 165
UniProt ID: O75365

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

277380

CNNM3
Metal transporter CNNM3

2

10

Small-scale

0.776

High

277349

TP4A2
Protein tyrosine phosphatase type IVA 2

4

16

High-throughput

0.699

High

277299

TP4A3
Protein tyrosine phosphatase type IVA 3

1

15

High-throughput

0.618

High

123526

MYO1C
Unconventional myosin-Ic

2

12

High-throughput

0.611

High

277325

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

7

High-throughput

0.601

High

277372

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

13

High-throughput

0.601

High

277384

IPO4
Importin-4

2

18

High-throughput

0.601

High

277436

FZR1
Fizzy-related protein homolog

1

10

Small-scale

0.561

High

277335

ITA1
Integrin alpha-1

1

3

Small-scale

0.552

High

277326

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

13

High-throughput

0.541

High

62867

POTEF
POTE ankyrin domain family member F

1

2

High-throughput

0.536

High

171134

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

12

High-throughput

0.536

High

277302

MYO1D
Unconventional myosin-Id

1

12

High-throughput

0.536

High

277315

SFPQ
Splicing factor, proline- and glutamine-rich

1

3

High-throughput

0.536

High

277322

MYH9
Myosin-9

1

4

High-throughput

0.536

High

277347

EWS
RNA-binding protein EWS

1

3

High-throughput

0.536

High

277348

MYO1E
Unconventional myosin-Ie

1

12

High-throughput

0.536

High

277370

MYH14
Myosin-14

1

4

High-throughput

0.536

High

277377

NIN
Ninein

1

16

High-throughput

0.536

High

277378

PR38A
Pre-mRNA-splicing factor 38A

1

1

High-throughput

0.536

High

277383

FAT3
Protocadherin Fat 3

1

2

High-throughput

0.536

High

277386

CATIN
Splicing factor Cactin

1

3

High-throughput

0.536

High

277393

LRCH3
DISP complex protein LRCH3

1

1

High-throughput

0.536

High

277401

DIDO1
Death-inducer obliterator 1

1

7

High-throughput

0.536

High

277402

ULBP3
UL16-binding protein 3

1

2

High-throughput

0.536

High

277409

MYO5C
Unconventional myosin-Vc

1

4

High-throughput

0.536

High

277416

SLTM
SAFB-like transcription modulator

1

8

High-throughput

0.536

High

277419

ARHGC
Rho guanine nucleotide exchange factor 12

1

3

High-throughput

0.536

High

277426

ZO2
Tight junction protein 2

1

8

High-throughput

0.536

High

277433

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

4

High-throughput

0.536

High

277434

NEB1
Neurabin-1

1

10

High-throughput

0.536

High

277435

MYO5B
Unconventional myosin-Vb

1

2

High-throughput

0.536

High

277438

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

3

High-throughput

0.536

High

277442

MYO5A
Unconventional myosin-Va

1

6

High-throughput

0.536

High

277447

KC1G3
Casein kinase I isoform gamma-3

1

3

High-throughput

0.536

High

277354

CUL2
Cullin-2

2

9

High-throughput

0.533

High

164494

TNPO2
Transportin-2

1

20

High-throughput

0.515

High

210816

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.515

High

277305

SMC2
Structural maintenance of chromosomes protein 2

1

6

High-throughput

0.515

High

277309

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.515

High

277314

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.515

High

277316

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.515

High

277317

MCM3
DNA replication licensing factor MCM3

1

10

High-throughput

0.515

High

277319

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.515

High

277327

MSH2
DNA mismatch repair protein Msh2

1

5

High-throughput

0.515

High

277356

UBE4A
Ubiquitin conjugation factor E4 A

1

1

High-throughput

0.515

High

277357

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

2

High-throughput

0.515

High

277366

ECM29
Proteasome adapter and scaffold protein ECM29

1

16

High-throughput

0.515

High

277389

GCN1
Stalled ribosome sensor GCN1

1

17

High-throughput

0.515

High

277408

XPO5
Exportin-5

1

16

High-throughput

0.515

High

277414

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.515

High

277431

XPO7
Exportin-7

1

13

High-throughput

0.515

High

277444

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.515

High

277306

SVIL
Supervillin

1

0

High-throughput

0.513

High

277346

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.513

High

277381

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

277418

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

1

0

High-throughput

0.513

High

277333

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

277334

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.493

High

277345

GTF2I
General transcription factor II-I

1

0

High-throughput

0.493

High

277373

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.493

High

277396

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.493

High

277400

CND3
Condensin complex subunit 3

1

0

High-throughput

0.493

High

277405

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.493

High

277365

PR38B
Pre-mRNA-splicing factor 38B

1

3

High-throughput

0.489

High

277369

MPRIP
Myosin phosphatase Rho-interacting protein

1

9

High-throughput

0.489

High

277390

K0232
Uncharacterized protein KIAA0232

1

1

High-throughput

0.489

High

277391

RMXL1
RNA binding motif protein, X-linked-like-1

1

4

High-throughput

0.489

High

277397

SCAFB
Protein SCAF11

1

5

High-throughput

0.489

High

277420

TMOD2
Tropomodulin-2

1

1

High-throughput

0.489

High

277422

RAI14
Ankycorbin

1

13

High-throughput

0.489

High

277342

TPM4
Tropomyosin alpha-4 chain

1

1

High-throughput

0.488

High

169851

AURKA
Aurora kinase A

1

6

Small-scale

0.479

High

184355

SURF4
Surfeit locus protein 4

1

1

High-throughput

0.479

High

227734

MYO1B
Unconventional myosin-Ib

1

12

High-throughput

0.479

High

245390

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

3

High-throughput

0.479

High

255544

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

3

High-throughput

0.479

High

277304

UBR5
E3 ubiquitin-protein ligase UBR5

1

18

High-throughput

0.479

High

277310

OAT
Ornithine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

277311

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

277312

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.479

High

277313

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.479

High

277320

DNJA1
DnaJ homolog subfamily A member 1

1

9

High-throughput

0.479

High

277321

MCM7
DNA replication licensing factor MCM7

1

7

High-throughput

0.479

High

277323

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

277324

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.479

High

277329

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

2

High-throughput

0.479

High

277332

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

8

High-throughput

0.479

High

277337

GEMI4
Gem-associated protein 4

1

3

High-throughput

0.479

High

277338

EPIPL
Epiplakin

1

11

High-throughput

0.479

High

277339

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

277341

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

277350

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

Small-scale

0.479

High

277352

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

277353

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

8

High-throughput

0.479

High

277355

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

4

High-throughput

0.479

High

277358

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

277374

SMAP1
Stromal membrane-associated protein 1

1

3

High-throughput

0.479

High

277379

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

277382

TBC15
TBC1 domain family member 15

1

2

High-throughput

0.479

High

277398

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.479

High

277399

NP1L4
Nucleosome assembly protein 1-like 4

1

5

High-throughput

0.479

High

277404

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

277406

UN45A
Protein unc-45 homolog A

1

13

High-throughput

0.479

High

277410

TBG2
Tubulin gamma-2 chain

1

7

High-throughput

0.479

High

277412

MDN1
Midasin

1

5

High-throughput

0.479

High

277423

ATX10
Ataxin-10

1

1

High-throughput

0.479

High

277425

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.479

High

277428

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.479

High

277429

VATH
V-type proton ATPase subunit H

1

1

High-throughput

0.479

High

277439

DICER
Endoribonuclease Dicer

1

9

High-throughput

0.479

High

277440

STRAP
Serine-threonine kinase receptor-associated protein

1

6

High-throughput

0.479

High

277441

DCAF1
DDB1- and CUL4-associated factor 1

1

5

High-throughput

0.479

High

277443

TNPO3
Transportin-3

1

20

High-throughput

0.479

High

255719

USO1
General vesicular transport factor p115

1

11

High-throughput

0.470

High

277318

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.470

High

277364

NU188
Nucleoporin NUP188

1

1

High-throughput

0.470

High

277367

TTC27
Tetratricopeptide repeat protein 27

1

2

High-throughput

0.470

High

277392

KBP
KIF-binding protein

1

1

High-throughput

0.470

High

277407

HEAT1
HEAT repeat-containing protein 1

1

2

High-throughput

0.470

High

277415

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

High-throughput

0.470

High

208006

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.458

High

211696

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.458

High

277303

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

277343

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.458

High

277351

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.458

High

277361

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

277362

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

277375

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

277394

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.458

High

277432

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.458

High

277308

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.437

High

277328

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

277330

FNTB
Protein farnesyltransferase subunit beta

1

4

High-throughput

0.437

High

277331

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

277340

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

High-throughput

0.437

High

277344

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.437

High

277359

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

1

High-throughput

0.437

High

277360

UBE3C
Ubiquitin-protein ligase E3C

1

13

High-throughput

0.437

High

277371

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.437

High

277376

NUP93
Nuclear pore complex protein Nup93

1

3

High-throughput

0.437

High

277385

PDC6I
Programmed cell death 6-interacting protein

1

7

High-throughput

0.437

High

277387

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.437

High

277388

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

14

High-throughput

0.437

High

277413

DJC11
DnaJ homolog subfamily C member 11

1

11

High-throughput

0.437

High

277421

HACD3
Very-long-chain

1

2

High-throughput

0.437

High

277427

SEC63
Translocation protein SEC63 homolog

1

11

High-throughput

0.437

High

277430

IPO11
Importin-11

1

13

High-throughput

0.437

High

277445

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

1

High-throughput

0.437

High

277446

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

3

High-throughput

0.437

High

277395

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

277417

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

277336

TMM33
Transmembrane protein 33

1

0

High-throughput

0.269

Low

49361

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

168063

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

0

High-throughput

0.249

Low

277300

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.249

Low

277301

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.249

Low

277307

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.249

Low

277363

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

277368

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.249

Low

277403

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.249

Low

277411

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

277424

NCDN
Neurochondrin

1

0

High-throughput

0.249

Low

277437

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025