HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 454
+	Hs
		348035 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347517 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Mm
		348444 FBXW7_MOUSE (1-202): 1.89e-47: 171: 20.85		MYC_MOUSE (1-454): 4.33e-119: 357: 89.01
+	Hs
		379270 RAE1L_HUMAN (3-326): 2.75e-99: 299: 33.63		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		346159 LIS1_HUMAN (168-319): 3.74e-31: 122: 14.47		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347550 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346404 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		379688 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Mm
		1112323 FBXW7_MOUSE (1-202): 1.89e-47: 171: 20.85		SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60
+	Mm
		1257396 FBXW7_MOUSE (1-202): 1.89e-47: 171: 20.85		SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61
+	Hs
		738987 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19
+	Hs
		379701 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379200 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		898168 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67
+	Hs
		607803 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		USF1_HUMAN (175-453): 1.02e-39: 146: 18.40
+	At
		189017 GBLPA_ARATH (70-297): 1.12e-20: 92.4: 18.75		MYC2_ARATH (200-454): 1.78e-32: 132: 18.05
+	Hs
		1218698 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71
+	Hs
		903353 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71
+	Mm
		659344 WDR5_MOUSE (209-320): 6.93e-20: 90.4: 16.07		MAX_MOUSE (354-454): 3.52e-25: 102: 32.67
+	Hs
		898091 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67