HitPredict

Interactor 1: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Interactor 2: TLR9 (Q9NR96)
Toll-like receptor 9 (CD antigen CD289)
Gene: TLR9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, LRR_8~ig, LRR_8~V-set
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Hs			1 1032
+	Hs
		1344383 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR9_HUMAN (1-1032): 2.75e-179: 551: 100.00
+	Hs
		211412 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR5_HUMAN (15-412): 2.47e-22: 105: 17.10
+	Hs
		211424 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR8_HUMAN (412-870): 2.94e-21: 102: 18.29
+	Hs
		179919 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR3_HUMAN (1-423): 7e-20: 98: 17.96
+	Hs
		120114 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR4_HUMAN (412-808): 6.07e-14: 78.3: 16.96
+	Mm
		1265201 SIG12_MOUSE (28-453): 2.65e-74: 242: 44.12		TLR4_MOUSE (10-609): 4.06e-31: 133: 19.22
+	Mm
		1162020 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR4_MOUSE (10-609): 4.06e-31: 133: 19.22
+	Hs
		211422 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR10_HUMAN (54-310): 2.78e-09: 63.2: 18.42
+	Hs
		237442 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR5_HUMAN (15-412): 2.47e-22: 105: 17.10
+	Hs
		1344389 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR8_HUMAN (412-870): 2.94e-21: 102: 18.29
+	Hs
		1348546 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR7_HUMAN (4-481): 1.19e-20: 100: 16.33
+	Hs
		179970 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR3_HUMAN (1-423): 7e-20: 98: 17.96
+	Mm
		1162021 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR2_MOUSE (422-907): 4.08e-17: 88.7: 16.52
+	Hs
		120187 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR4_HUMAN (412-808): 6.07e-14: 78.3: 16.96
+	Hs
		237523 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR2_HUMAN (15-575): 1.29e-12: 74: 16.93
+	Hs
		120185 SIGL7_HUMAN (23-453): 3.93e-74: 241: 50.11		TLR4_HUMAN (412-808): 6.07e-14: 78.3: 16.96
+	Mm
		885977 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR8_MOUSE (12-186): 4.37e-13: 76: 18.09
+	Hs
		1073338 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR1_HUMAN (433-605): 5.38e-10: 65.6: 20.81
+	Hs
		1315643 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR10_HUMAN (54-310): 2.78e-09: 63.2: 18.42
+	Mm
		1162019 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR1_MOUSE (651-759): 2.8e-09: 63.3: 27.52