Protein: JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR)

Gene: JMJD6
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q6NYC1

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0002040 - sprouting angiogenesis
GO:0003723 - RNA binding
GO:0003727 - single-stranded RNA binding
GO:0005506 - iron ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1239683

PHRF1
PHD and RING finger domain-containing protein 1

3

5

Small-scale

0.770

High

260087

BRD4
Bromodomain-containing protein 4

10

12

Small-scale

0.759

High

1239694

LC7L2
Putative RNA-binding protein Luc7-like 2

6

2

Small-scale

0.730

High

1160166

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

4

8

Small-scale

0.702

High

1239691

CCNL1
Cyclin-L1

4

2

High-throughput

0.697

High

280670

PR40A
Pre-mRNA-processing factor 40 homolog A

4

7

Small-scale

0.694

High

1239656

DIDO1
Death-inducer obliterator 1

1

7

High-throughput

0.691

High

1126952

RBM39
RNA-binding protein 39

4

5

Small-scale

0.691

High

1239621

DHX40
Probable ATP-dependent RNA helicase DHX40

4

7

High-throughput

0.691

High

1239647

RSRC1
Serine/Arginine-related protein 53

5

0

Small-scale

0.687

High

1028664

U2AF1
Splicing factor U2AF 35 kDa subunit

3

2

High-throughput

0.683

High

1239675

ZCC17
Zinc finger CCHC domain-containing protein 17

3

1

High-throughput

0.683

High

1239629

PR38A
Pre-mRNA-splicing factor 38A

4

0

Small-scale

0.675

High

1239662

NAA50
N-alpha-acetyltransferase 50

3

1

High-throughput

0.675

High

889756

CLK3
Dual specificity protein kinase CLK3

3

5

High-throughput

0.675

High

1239625

NKAP
NF-kappa-B-activating protein

3

1

High-throughput

0.675

High

279396

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

889126

RBM25
RNA-binding protein 25

3

1

Small-scale

0.667

High

1051486

SRS11
Serine/arginine-rich splicing factor 11

3

1

Small-scale

0.667

High

1088261

SFSWA
Splicing factor, suppressor of white-apricot homolog

3

3

Small-scale

0.667

High

1128027

DHX8
ATP-dependent RNA helicase DHX8

3

7

High-throughput

0.667

High

1152331

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

2

High-throughput

0.667

High

1239618

RBM23
Probable RNA-binding protein 23

3

4

Small-scale

0.667

High

1239636

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

3

2

High-throughput

0.667

High

1239652

CCNL2
Cyclin-L2

3

2

Small-scale

0.667

High

1239672

CLK4
Dual specificity protein kinase CLK4

3

5

Small-scale

0.667

High

1239623

FAM9A
Protein FAM9A

3

2

High-throughput

0.664

High

871953

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

3

High-throughput

0.662

High

1239657

MMTA2
Multiple myeloma tumor-associated protein 2

3

1

High-throughput

0.662

High

1239689

PUF60
Poly(U)-binding-splicing factor PUF60

3

5

Small-scale

0.662

High

1239609

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

4

Small-scale

0.647

High

1226768

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

0

High-throughput

0.638

High

1229462

CDCA2
Cell division cycle-associated protein 2

3

0

Small-scale

0.638

High

1239617

RSRC2
Arginine/serine-rich coiled-coil protein 2

3

0

Small-scale

0.638

High

1239663

NSRP1
Nuclear speckle splicing regulatory protein 1

3

0

Small-scale

0.638

High

1239680

ARGL1
Arginine and glutamate-rich protein 1

3

0

High-throughput

0.638

High

1239677

LUC7L
Putative RNA-binding protein Luc7-like 1

4

2

Small-scale

0.633

High

175709

SR140
U2 snRNP-associated SURP motif-containing protein

2

2

High-throughput

0.628

High

326347

SCAF4
SR-related and CTD-associated factor 4

2

4

High-throughput

0.628

High

330466

LC7L3
Luc7-like protein 3

2

2

High-throughput

0.628

High

340754

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

1

High-throughput

0.628

High

636099

CD11B
Cyclin-dependent kinase 11B

2

7

High-throughput

0.628

High

685613

U2AF2
Splicing factor U2AF 65 kDa subunit

2

7

High-throughput

0.628

High

1034584

AK17A
A-kinase anchor protein 17A

2

1

High-throughput

0.628

High

1104962

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

1

High-throughput

0.628

High

1214632

RBM26
RNA-binding protein 26

2

2

High-throughput

0.628

High

1217816

PR38B
Pre-mRNA-splicing factor 38B

2

1

High-throughput

0.628

High

1239616

DDX46
Probable ATP-dependent RNA helicase DDX46

2

7

High-throughput

0.628

High

1239620

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

2

High-throughput

0.628

High

1239626

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

3

High-throughput

0.628

High

1239631

WDR48
WD repeat-containing protein 48

2

6

High-throughput

0.628

High

1239635

RN138
E3 ubiquitin-protein ligase RNF138

2

8

High-throughput

0.628

High

1239640

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

7

High-throughput

0.628

High

1239648

RNPC3
RNA-binding region-containing protein 3

2

1

High-throughput

0.628

High

1239653

SCAFB
Protein SCAF11

2

3

High-throughput

0.628

High

1239661

WDR33
pre-mRNA 3' end processing protein WDR33

2

4

High-throughput

0.628

High

1239667

SFR19
Splicing factor, arginine/serine-rich 19

2

4

High-throughput

0.628

High

1239670

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

2

2

High-throughput

0.628

High

1239685

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.628

High

1239692

SCAF8
SR-related and CTD-associated factor 8

2

1

High-throughput

0.628

High

1239693

ZC3H4
Zinc finger CCCH domain-containing protein 4

2

2

High-throughput

0.628

High

1239695

RBMX2
RNA-binding motif protein, X-linked 2

2

5

High-throughput

0.628

High

1239697

HBS1L
HBS1-like protein

2

1

High-throughput

0.628

High

1239646

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

1

High-throughput

0.611

High

414033

P53
Cellular tumor antigen p53

1

2

Small-scale

0.603

High

228286

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

0

High-throughput

0.602

High

600319

ZNF24
Zinc finger protein 24

2

0

High-throughput

0.602

High

770394

T2FA
General transcription factor IIF subunit 1

2

0

High-throughput

0.602

High

1156654

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

2

0

High-throughput

0.602

High

1210718

ZMYM1
Zinc finger MYM-type protein 1

2

0

High-throughput

0.602

High

1239633

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

0

High-throughput

0.602

High

1239634

CATIN
Splicing factor Cactin

2

0

High-throughput

0.602

High

1239686

IKBL1
NF-kappa-B inhibitor-like protein 1

2

0

High-throughput

0.602

High

1239700

PAXB1
PAX3- and PAX7-binding protein 1

2

0

High-throughput

0.602

High

242017

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

674210

BRD2
Bromodomain-containing protein 2

2

17

High-throughput

0.584

High

1239615

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1239650

FRMD6
FERM domain-containing protein 6

1

3

High-throughput

0.573

High

396330

ESR1
Estrogen receptor

1

15

Small-scale

0.568

High

897862

CDK9
Cyclin-dependent kinase 9

1

8

Small-scale

0.561

High

1129150

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.561

High

1239654

RNF5
E3 ubiquitin-protein ligase RNF5

1

1

Small-scale

0.561

High

214217

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

1

High-throughput

0.536

High

217458

E41L2
Band 4.1-like protein 2

1

1

High-throughput

0.536

High

239586

MED14
Mediator of RNA polymerase II transcription subunit 14

1

8

High-throughput

0.536

High

542071

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

595802

H13
Histone H1.3

1

3

High-throughput

0.536

High

615405

SON
Protein SON

1

1

High-throughput

0.536

High

768441

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.536

High

997791

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

1025312

CDKL1
Cyclin-dependent kinase-like 1

1

8

High-throughput

0.536

High

1122080

UBP2L
Ubiquitin-associated protein 2-like

1

7

High-throughput

0.536

High

1158753

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

1

5

High-throughput

0.536

High

1239655

BUD13
BUD13 homolog

1

1

High-throughput

0.536

High

1239660

SETD2
Histone-lysine N-methyltransferase SETD2

1

2

High-throughput

0.536

High

1239673

PKHA2
Pleckstrin homology domain-containing family A member 2

1

1

High-throughput

0.536

High

1239684

RBM27
RNA-binding protein 27

1

1

High-throughput

0.536

High

1239690

DDX41
Probable ATP-dependent RNA helicase DDX41

1

4

High-throughput

0.536

High

48975

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.513

High

250102

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.513

High

257886

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

358886

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.513

High

884121

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

890203

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.513

High

967467

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.513

High

1136971

SEPT2
Septin-2

1

0

High-throughput

0.513

High

1149845

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.513

High

1191583

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

1239628

SYT2
Synaptotagmin-2

1

0

High-throughput

0.513

High

1239630

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1239679

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

1239682

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

1239696

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

449737

H2B1J
Histone H2B type 1-J

1

7

High-throughput

0.508

High

968738

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.508

High

1133473

NFIX
Nuclear factor 1 X-type

1

15

High-throughput

0.508

High

1194151

LARP7
La-related protein 7

1

7

High-throughput

0.508

High

1239611

AEBP2
Zinc finger protein AEBP2

1

3

High-throughput

0.508

High

1239612

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.508

High

1239622

SLN12
Ribonuclease SLFN12

1

3

High-throughput

0.508

High

1239649

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

2

High-throughput

0.508

High

1239681

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

2

High-throughput

0.508

High

1239698

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.508

High

185778

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

979839

H4
Histone H4

1

6

Small-scale

0.501

High

998444

H31
Histone H3.1

1

20

Small-scale

0.501

High

650813

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.500

High

276143

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.489

High

335472

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.486

High

349319

GNA14
Guanine nucleotide-binding protein subunit alpha-14

1

0

High-throughput

0.486

High

1130696

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.486

High

1150333

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

High-throughput

0.486

High

1239613

LIAT1
Protein LIAT1

1

0

High-throughput

0.486

High

1239624

CENPL
Centromere protein L

1

0

High-throughput

0.486

High

1239619

CARM1
Histone-arginine methyltransferase CARM1

1

0

Small-scale

0.479

High

251598

CCNT1
Cyclin-T1

1

3

Small-scale

0.479

High

551103

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

698771

CALX
Calnexin

1

1

Small-scale

0.479

High

727848

DNJA1
DnaJ homolog subfamily A member 1

1

2

Small-scale

0.479

High

842657

WASP
Actin nucleation-promoting factor WAS

1

2

Small-scale

0.479

High

879193

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

1031107

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

1

Small-scale

0.479

High

1054725

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.479

High

1121037

BOP1
Ribosome biogenesis protein BOP1

1

4

Small-scale

0.479

High

1142303

PDIA6
Protein disulfide-isomerase A6

1

3

High-throughput

0.479

High

1226877

A16L1
Autophagy-related protein 16-1

1

6

Small-scale

0.479

High

1239614

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1239639

HS105
Heat shock protein 105 kDa

1

3

Small-scale

0.479

High

1239669

BRD9
Bromodomain-containing protein 9

1

10

High-throughput

0.479

High

1239674

WDR6
tRNA

1

7

Small-scale

0.479

High

1239687

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1239699

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

1239678

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

15

High-throughput

0.464

High

1239688

HMGX4
HMG domain-containing protein 4

1

7

High-throughput

0.464

High

179526

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

189061

NCAM2
Neural cell adhesion molecule 2

1

0

Small-scale

0.458

High

299245

FLOT1
Flotillin-1

1

0

Small-scale

0.458

High

428171

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.458

High

601732

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

935535

MFAP1
Microfibrillar-associated protein 1

1

0

Small-scale

0.458

High

958128

ARP3
Actin-related protein 3

1

0

Small-scale

0.458

High

1138313

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1239638

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1239645

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1239664

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1239665

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1239671

UCK1
Uridine-cytidine kinase 1

1

0

Small-scale

0.458

High

141533

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.445

High

250666

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

Small-scale

0.445

High

472820

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

Small-scale

0.445

High

550329

PABP1
Polyadenylate-binding protein 1

1

2

Small-scale

0.445

High

557349

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.445

High

576439

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

3

Small-scale

0.445

High

608637

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.445

High

620423

NUCL
Nucleolin

1

2

Small-scale

0.445

High

655238

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

Small-scale

0.445

High

775151

FUS
RNA-binding protein FUS

1

4

Small-scale

0.445

High

1033027

EWS
RNA-binding protein EWS

1

2

Small-scale

0.445

High

1100835

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

Small-scale

0.445

High

1101994

PABP4
Polyadenylate-binding protein 4

1

2

Small-scale

0.445

High

1144377

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.445

High

1239637

PSPC1
Paraspeckle component 1

1

7

Small-scale

0.445

High

1239641

TFG
Protein TFG

1

5

Small-scale

0.445

High

1239642

RBP56
TATA-binding protein-associated factor 2N

1

3

Small-scale

0.445

High

1239643

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.445

High

1239644

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

1

Small-scale

0.445

High

1239651

RBM14
RNA-binding protein 14

1

4

Small-scale

0.445

High

1239658

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

7

Small-scale

0.445

High

1239666

E41L1
Band 4.1-like protein 1

1

2

High-throughput

0.445

High

699780

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.426

High

965734

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

Small-scale

0.426

High

1148988

SC23B
Protein transport protein Sec23B

1

0

Small-scale

0.426

High

1239676

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.426

High

1152323

U2AFL
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

1

2

High-throughput

0.407

High

1239668

CAAP1
Caspase activity and apoptosis inhibitor 1

2

0

High-throughput

0.328

High

1162175

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.279

Low

1239627

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1239632

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1239610

RSPO2
R-spondin-2

1

0

High-throughput

0.265

Low

343149

CXL14
C-X-C motif chemokine 14

1

0

Small-scale

0.261

Low

1205112

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

Small-scale

0.249

Low

1239659

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

Small-scale

0.249

Low

516102

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

516945

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025