HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: ICAM1 (P05362)
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Gene: ICAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23463506
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 911 Hs			1 532
+	Hs
		399959 ACTN1_HUMAN (20-911): 0: 607: 85.76		ICAM1_HUMAN (1-532): 7.16e-102: 318: 100.00
+	Rn
		88917 ACTN1_RAT (20-911): 0: 608: 85.99		D4A435_RAT (26-494): 9.72e-37: 147: 16.87
+	Hs
		521638 ACTN1_HUMAN (20-911): 0: 607: 85.76		ICAM5_HUMAN (1-206): 1.39e-17: 88.4: 16.29
+	Hs
		211493 ACTN4_HUMAN (1-911): 0: 586: 100.00		VCAM1_HUMAN (228-500): 5e-20: 95.8: 18.57
+	Hs
		521586 ACTN1_HUMAN (20-911): 0: 607: 85.76		TITIN_HUMAN (89-526): 5.58e-11: 67.7: 12.16
+	Hs
		211629 ACTN4_HUMAN (1-911): 0: 586: 100.00		TITIN_HUMAN (89-526): 5.58e-11: 67.7: 12.16
+	Hs
		993278 ACTN3_HUMAN (37-911): 0: 567: 74.51		TITIN_HUMAN (89-526): 5.58e-11: 67.7: 12.16
+	Hs
		725681 ACTN2_HUMAN (19-911): 0: 556: 77.16		TITIN_HUMAN (89-526): 5.58e-11: 67.7: 12.16
+	Hs
		506801 SPTB1_HUMAN (213-819): 7.03e-09: 62: 10.57		NCAM1_HUMAN (9-524): 1.88e-83: 278: 13.01
+	Hs
		581681 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		VCAM1_HUMAN (228-500): 5e-20: 95.8: 18.57