Protein: PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]

Gene: PAPS2, PAPSS2
Organism: Homo sapiens
Interactions: 44
UniProt ID: O95340

Gene Ontology (top 5):
GO:0000103 - sulfate assimilation
GO:0004020 - adenylylsulfate kinase activity
GO:0004781 - sulfate adenylyltransferase (ATP) activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211466

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

3

7

High-throughput

0.855

High

333878

WDR6
tRNA

2

2

High-throughput

0.628

High

240368

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

269136

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

333871

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

333854

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

333860

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

333845

TBX18
T-box transcription factor TBX18

1

0

High-throughput

0.513

High

333865

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.513

High

333880

SPNXB
Sperm protein associated with the nucleus on the X chromosome B1

1

0

High-throughput

0.513

High

333883

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

333859

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

333861

RBM3
RNA-binding protein 3

1

0

High-throughput

0.493

High

333870

OPTN
Optineurin

1

0

High-throughput

0.493

High

333876

DJC18
DnaJ homolog subfamily C member 18

1

1

High-throughput

0.489

High

333850

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

333853

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

333857

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

333867

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

333868

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

333847

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

333858

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

333862

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

333863

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

333874

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

333875

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

333877

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

333872

MCRI2
MAPK regulated corepressor interacting protein 2

1

1

High-throughput

0.445

High

333882

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

333848

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

258695

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.426

High

333879

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

333856

CD27
CD27 antigen

1

1

High-throughput

0.407

High

333884

PCDG9
Protocadherin gamma-A9

1

1

High-throughput

0.407

High

333852

CO8B
Complement component C8 beta chain

1

0

High-throughput

0.279

Low

333869

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

333873

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

333846

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

333849

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

333881

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

Small-scale

0.249

Low

333851

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

333855

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

333864

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

333866

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025