HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: SYNPO (Q8N3V7)
Synaptopodin
Gene: SYNPO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0003779 - actin binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton and 1 others more... GO:0030018 - Z disc
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 911 Hs			1 929
+	Hs
		521576 ACTN1_HUMAN (20-911): 0: 607: 85.76		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		521616 ACTN1_HUMAN (20-911): 0: 607: 85.76		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		993296 ACTN3_HUMAN (37-911): 0: 567: 74.51		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		725700 ACTN2_HUMAN (19-911): 0: 556: 77.16		SYP2L_HUMAN (391-924): 7.17e-28: 123: 22.96
+	Hs
		521599 ACTN1_HUMAN (20-911): 0: 607: 85.76		CIC_HUMAN (71-922): 9.17e-10: 65.1: 8.24
+	Hs
		725714 ACTN2_HUMAN (19-911): 0: 556: 77.16		SYNP2_HUMAN (450-925): 1.51e-25: 116: 18.90
+	Hs
		963367 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		164638 SPTN2_HUMAN (262-846): 1.08e-09: 64.7: 12.62		SYNPO_HUMAN (14-929): 5.01e-115: 376: 100.00
+	Hs
		963358 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		MICA3_HUMAN (231-870): 4.24e-27: 121: 12.97
+	Dm
		54271 A1Z9I8_DROME (245-823): 5.01e-09: 62.8: 10.17		Q9VLS7_DROME (7-866): 6.18e-15: 82: 9.37
+	Hs
		963398 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		CIC_HUMAN (71-922): 9.17e-10: 65.1: 8.24