Protein: P3H1
Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1)

Gene: P3H1
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q32P28

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1181392

P3H3
Prolyl 3-hydroxylase 3

1

3

High-throughput

0.691

High

292004

CRTAP
Cartilage-associated protein

3

3

High-throughput

0.671

High

1181412

EDA
Ectodysplasin-A

3

9

High-throughput

0.667

High

1181415

HOOK2
Protein Hook homolog 2

3

1

High-throughput

0.662

High

1181402

ZN397
Zinc finger protein 397

3

3

High-throughput

0.650

High

326201

ALX3
Homeobox protein aristaless-like 3

2

3

High-throughput

0.628

High

1160147

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

6

High-throughput

0.628

High

1181372

INAVA
Innate immunity activator protein

2

5

High-throughput

0.628

High

1181391

VP37D
Vacuolar protein sorting-associated protein 37D

2

1

High-throughput

0.628

High

1181441

ZN446
Zinc finger protein 446

2

5

High-throughput

0.628

High

566694

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.618

High

1181395

DJC10
DnaJ homolog subfamily C member 10

1

6

High-throughput

0.618

High

372178

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

521370

ARAF
Serine/threonine-protein kinase A-Raf

2

1

High-throughput

0.611

High

668781

CO8A2
Collagen alpha-2(VIII) chain

2

18

High-throughput

0.611

High

1181374

TGO1
Transport and Golgi organization protein 1 homolog

2

2

High-throughput

0.611

High

1181453

T22D4
TSC22 domain family protein 4

2

2

High-throughput

0.611

High

904478

RENBP
N-acylglucosamine 2-epimerase

2

0

High-throughput

0.602

High

1181373

TIGD5
Tigger transposable element-derived protein 5

2

0

High-throughput

0.602

High

1181433

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.586

High

1181435

FBX6
F-box only protein 6

2

1

High-throughput

0.584

High

1181389

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

2

0

High-throughput

0.576

High

1181382

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

3

High-throughput

0.575

High

63757

KRBA1
Protein KRBA1

2

1

High-throughput

0.574

High

1181428

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

1

High-throughput

0.574

High

1181451

COLQ
Acetylcholinesterase collagenic tail peptide

2

10

High-throughput

0.574

High

1181437

MBIP1
MAP3K12-binding inhibitory protein 1

2

1

High-throughput

0.558

High

1181418

CC120
Coiled-coil domain-containing protein 120

2

5

High-throughput

0.549

High

167092

GEMI2
Gem-associated protein 2

1

1

High-throughput

0.536

High

211647

ZNHI1
Zinc finger HIT domain-containing protein 1

1

1

High-throughput

0.536

High

228272

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.536

High

405606

HRG
Histidine-rich glycoprotein

1

5

High-throughput

0.536

High

567873

PRG2
Bone marrow proteoglycan

1

5

High-throughput

0.536

High

694337

CO8A1
Collagen alpha-1(VIII) chain

1

16

High-throughput

0.536

High

755400

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

1

High-throughput

0.536

High

973937

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.536

High

991193

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

High-throughput

0.536

High

1043627

COAA1

1

17

High-throughput

0.536

High

1145226

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

1148500

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.536

High

1181377

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

1

High-throughput

0.536

High

1181380

TRI68
E3 ubiquitin-protein ligase TRIM68

1

1

High-throughput

0.536

High

1181394

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1181401

ADAD2
Adenosine deaminase domain-containing protein 2

1

1

High-throughput

0.536

High

1181404

WDR48
WD repeat-containing protein 48

1

1

High-throughput

0.536

High

1181410

SC65
Endoplasmic reticulum protein SC65

1

3

High-throughput

0.536

High

1181413

EMID1
EMI domain-containing protein 1

1

9

High-throughput

0.536

High

1181416

F163A
Protein FAM163A

1

1

High-throughput

0.536

High

1181419

AJUBA
LIM domain-containing protein ajuba

1

2

High-throughput

0.536

High

1181424

GA2L1
GAS2-like protein 1

1

2

High-throughput

0.536

High

1181429

IKZF4
Zinc finger protein Eos

1

5

High-throughput

0.536

High

1181430

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

High-throughput

0.536

High

1181445

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.536

High

1181455

RBM8A
RNA-binding protein 8A

1

4

High-throughput

0.536

High

155671

FCHO1
F-BAR domain only protein 1

1

0

High-throughput

0.513

High

175064

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.513

High

269453

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.513

High

554227

BMP4
Bone morphogenetic protein 4

1

0

High-throughput

0.513

High

591675

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

660268

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.513

High

791433

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

932367

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

1057614

CDK18
Cyclin-dependent kinase 18

1

0

High-throughput

0.513

High

1098315

SEM3B
Semaphorin-3B

1

0

High-throughput

0.513

High

1131469

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.513

High

1181384

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.513

High

1181405

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1181417

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.513

High

1181431

TOR3A
Torsin-3A

1

0

High-throughput

0.513

High

1181436

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.513

High

1162945

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.493

High

73811

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.489

High

168408

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

281745

VP26A
Vacuolar protein sorting-associated protein 26A

1

1

High-throughput

0.489

High

1181393

SFPA2
Pulmonary surfactant-associated protein A2

1

13

High-throughput

0.489

High

955236

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

132079

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

218248

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

241849

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

247942

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

363361

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

406237

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

412028

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

413942

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

535131

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

574099

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

4

High-throughput

0.479

High

822694

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

1098408

DNJC3
DnaJ homolog subfamily C member 3

1

7

High-throughput

0.479

High

1113243

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1140358

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1181375

EPHAA
Ephrin type-A receptor 10

1

2

High-throughput

0.479

High

1181386

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1181387

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1181396

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.479

High

1181409

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

Small-scale

0.479

High

1181414

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1181420

CALR3
Calreticulin-3

1

4

High-throughput

0.479

High

1181432

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

229725

CALU
Calumenin

1

0

High-throughput

0.458

High

472313

CFAH
Complement factor H

1

0

Small-scale

0.458

High

951180

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

975718

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

1033692

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1179089

TECT1
Tectonic-1

1

0

High-throughput

0.458

High

1181376

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1181398

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1181400

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1181443

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1181444

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

1181446

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

1181447

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1181452

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

321558

PRP6
Pre-mRNA-processing factor 6

1

3

High-throughput

0.445

High

384163

CO1A1
Collagen alpha-1(I) chain

1

3

Small-scale

0.445

High

400919

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

424600

PAI1
Plasminogen activator inhibitor 1

1

1

High-throughput

0.445

High

635457

CO5A1

1

3

High-throughput

0.445

High

839288

MTOR
Serine/threonine-protein kinase mTOR

1

2

High-throughput

0.445

High

1102178

ATM
Serine-protein kinase ATM

1

2

High-throughput

0.445

High

1181388

TMTC3
Protein O-mannosyl-transferase TMTC3

1

3

High-throughput

0.445

High

269962

AUXI
Auxilin

1

2

High-throughput

0.437

High

1181422

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

4

High-throughput

0.437

High

1181439

T106B
Transmembrane protein 106B

1

3

High-throughput

0.437

High

187519

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.426

High

329838

SNX4
Sorting nexin-4

1

0

High-throughput

0.426

High

335997

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.426

High

637905

NF1
Neurofibromin

1

0

High-throughput

0.426

High

841040

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

897574

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.426

High

1043209

TAP2
Antigen peptide transporter 2

1

0

High-throughput

0.426

High

1181381

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.426

High

1181383

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.426

High

1181390

INT8
Integrator complex subunit 8

1

0

High-throughput

0.426

High

1181397

INT1
Integrator complex subunit 1

1

0

High-throughput

0.426

High

1181406

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.426

High

1181407

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.426

High

1181408

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.426

High

1181411

SYMPK
Symplekin

1

0

High-throughput

0.426

High

1181438

MDN1
Midasin

1

0

High-throughput

0.426

High

1181450

INT6
Integrator complex subunit 6

1

0

High-throughput

0.426

High

1181454

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

332220

UCP5
Brain mitochondrial carrier protein 1

1

3

High-throughput

0.407

High

1147525

UBE3C
Ubiquitin-protein ligase E3C

1

3

High-throughput

0.407

High

1181378

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

1181379

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1181442

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

1

High-throughput

0.407

High

1181425

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

3

0

High-throughput

0.345

High

1181440

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

3

0

High-throughput

0.345

High

164737

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

194829

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.279

Low

876255

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.279

Low

1181399

NPW
Neuropeptide W

1

0

High-throughput

0.279

Low

1181448

METRN
Meteorin

1

0

High-throughput

0.279

Low

1181449

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.279

Low

329276

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.249

Low

1126093

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1181385

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

177550

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.232

Low

1181403

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.232

Low

1181421

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low

1181423

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1181426

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.232

Low

1181427

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.232

Low

1181434

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025