HitPredict

Interactor 1: CIKS (O43734)
E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
Gene: TRAF3IP2

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	23066157, 22851696
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0048255 - mRNA stabilization GO:0097400 - interleukin-17-mediated signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 716
+	Hs
		212275 CIKS_HUMAN (1-574): 0: 1032: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158351 CIKS_HUMAN (1-574): 0: 1032: 100.00		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167423 CIKS_HUMAN (1-574): 0: 1032: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Mm
		1237188 CIKS_MOUSE (10-574): 0: 905: 78.32		TBK1_MOUSE (1-714): 2.98e-162: 486: 46.78
+	Mm
		1237187 CIKS_MOUSE (10-574): 0: 905: 78.32		IKKE_MOUSE (1-716): 1.49e-161: 485: 82.34