Protein: NDKB
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)

Gene: NDKB, NME2
Organism: Homo sapiens
Interactions: 229
UniProt ID: P22392

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0004673 - protein histidine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584704

NDKA
Nucleoside diphosphate kinase A

9

17

Small-scale

0.966

High

648087

NDKB
Nucleoside diphosphate kinase B

6

16

Small-scale

0.934

High

648150

NDK3
Nucleoside diphosphate kinase 3

5

17

Small-scale

0.929

High

143798

NDKM
Nucleoside diphosphate kinase, mitochondrial

3

17

High-throughput

0.849

High

240755

PRKN
E3 ubiquitin-protein ligase parkin

3

8

Small-scale

0.656

High

529082

TAU
Microtubule-associated protein tau

3

2

High-throughput

0.650

High

395492

ESR1
Estrogen receptor

3

5

Small-scale

0.633

High

387788

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

3

High-throughput

0.611

High

388856

A2GL
Leucine-rich alpha-2-glycoprotein

2

1

High-throughput

0.611

High

421506

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.611

High

648128

NPC2
NPC intracellular cholesterol transporter 2

2

3

High-throughput

0.611

High

648169

CCNG2
Cyclin-G2

2

4

High-throughput

0.611

High

648244

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.611

High

648115

ACLY
ATP-citrate synthase

2

1

Small-scale

0.601

High

648232

TRABD
TraB domain-containing protein

3

2

High-throughput

0.599

High

532358

CH60
60 kDa heat shock protein, mitochondrial

2

6

High-throughput

0.584

High

648118

TERA
Transitional endoplasmic reticulum ATPase

2

3

High-throughput

0.584

High

248195

NDK8
Putative nucleoside diphosphate kinase

1

17

High-throughput

0.575

High

648173

Q32Q12
Nucleoside diphosphate kinase

1

16

High-throughput

0.575

High

648132

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.571

High

648197

RHG24
Rho GTPase-activating protein 24

2

3

High-throughput

0.571

High

648210

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

2

High-throughput

0.571

High

648239

RHG35
Rho GTPase-activating protein 35

2

4

High-throughput

0.571

High

161558

ITBP1
Integrin beta-1-binding protein 1

1

0

Small-scale

0.561

High

648234

WDR76
WD repeat-containing protein 76

2

0

High-throughput

0.559

High

648248

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.552

High

648110

DYN2
Dynamin-2

1

5

Small-scale

0.550

High

648144

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.549

High

648178

HRG1
Heme transporter HRG1

2

1

High-throughput

0.549

High

648205

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

648112

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

648153

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.541

High

210709

KLK10
Kallikrein-10

1

5

High-throughput

0.536

High

323025

WDR47
WD repeat-containing protein 47

1

1

High-throughput

0.536

High

507078

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

7

High-throughput

0.536

High

599267

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

1

High-throughput

0.536

High

648125

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

648138

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.536

High

648142

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.536

High

648143

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

4

High-throughput

0.536

High

648222

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

High-throughput

0.536

High

648230

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

2

High-throughput

0.536

High

648233

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.536

High

648259

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

631061

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.518

High

165258

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.515

High

648089

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.515

High

648096

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.515

High

648120

EPIPL
Epiplakin

1

2

High-throughput

0.515

High

648134

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.515

High

648149

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

1

High-throughput

0.515

High

648164

PDIA6
Protein disulfide-isomerase A6

1

3

High-throughput

0.515

High

648176

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.515

High

648250

RUVB2
RuvB-like 2

1

2

High-throughput

0.515

High

314946

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.513

High

376975

ANF
Natriuretic peptides A

1

0

High-throughput

0.513

High

648101

ACTN2
Alpha-actinin-2

1

0

High-throughput

0.513

High

648102

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.513

High

648104

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

648108

CSRP3
Cysteine and glycine-rich protein 3

1

0

High-throughput

0.513

High

648201

FA24B
Protein FAM24B

1

0

High-throughput

0.513

High

648207

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.513

High

648208

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

648209

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

648221

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.513

High

648229

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

648223

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.500

High

648095

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.493

High

648097

KINH
Kinesin-1 heavy chain

1

0

High-throughput

0.493

High

648114

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.493

High

648127

LYSC
Lysozyme C

1

0

High-throughput

0.493

High

648137

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.493

High

648156

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.493

High

648167

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.493

High

476524

CEL3B
Chymotrypsin-like elastase family member 3B

1

2

High-throughput

0.489

High

648200

ARG39
Rho guanine nucleotide exchange factor 39

1

2

High-throughput

0.489

High

648163

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

3

Small-scale

0.481

High

648192

HERC6
Probable E3 ubiquitin-protein ligase HERC6

1

3

Small-scale

0.481

High

143555

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

1

High-throughput

0.479

High

176146

PER2
Period circadian protein homolog 2

1

1

Small-scale

0.479

High

212153

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.479

High

229649

CALU
Calumenin

1

5

High-throughput

0.479

High

251194

RNBP6
Ran-binding protein 6

1

2

High-throughput

0.479

High

293199

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

346850

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.479

High

366569

CFAB
Complement factor B

1

4

High-throughput

0.479

High

400282

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

408675

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

430987

LA
Lupus La protein

1

1

High-throughput

0.479

High

474477

VIME
Vimentin

1

2

Small-scale

0.479

High

521202

ARAF
Serine/threonine-protein kinase A-Raf

1

6

High-throughput

0.479

High

534631

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

536501

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

577386

OXDA
D-amino-acid oxidase

1

1

High-throughput

0.479

High

578380

BRAF
Serine/threonine-protein kinase B-raf

1

5

High-throughput

0.479

High

584471

VAV
Proto-oncogene vav

1

4

High-throughput

0.479

High

587918

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

592799

CBR1
Carbonyl reductase [NADPH] 1

1

3

High-throughput

0.479

High

606225

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

612869

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

640758

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.479

High

648088

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

648090

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.479

High

648091

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

648092

PSB4
Proteasome subunit beta type-4

1

6

High-throughput

0.479

High

648094

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.479

High

648098

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

648105

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

648107

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

648109

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.479

High

648111

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

648113

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.479

High

648116

RD23A
UV excision repair protein RAD23 homolog A

1

5

High-throughput

0.479

High

648119

HDAC4
Histone deacetylase 4

1

4

High-throughput

0.479

High

648121

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

3

High-throughput

0.479

High

648123

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

High-throughput

0.479

High

648129

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.479

High

648130

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

648133

H4
Histone H4

1

1

High-throughput

0.479

High

648135

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.479

High

648136

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.479

High

648140

H33
Histone H3.3

1

1

High-throughput

0.479

High

648145

SET
Protein SET

1

2

High-throughput

0.479

High

648146

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.479

High

648147

CO7A1
Collagen alpha-1(VII) chain

1

2

High-throughput

0.479

High

648148

SOS1
Son of sevenless homolog 1

1

3

High-throughput

0.479

High

648151

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

648159

GOGB1
Golgin subfamily B member 1

1

3

High-throughput

0.479

High

648160

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

648161

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

648162

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

648165

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

648168

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

648170

RHG44
Rho GTPase-activating protein 44

1

3

High-throughput

0.479

High

648171

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

648172

RHG31
Rho GTPase-activating protein 31

1

4

High-throughput

0.479

High

648175

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.479

High

648180

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

648181

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

648184

ASXL2
Putative Polycomb group protein ASXL2

1

5

High-throughput

0.479

High

648187

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

648189

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

648191

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

648193

ASXL1
Polycomb group protein ASXL1

1

4

High-throughput

0.479

High

648194

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

648195

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

648203

DYLT5
Dynein light chain Tctex-type 5

1

2

High-throughput

0.479

High

648204

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.479

High

648206

PLBL2
Putative phospholipase B-like 2

1

1

High-throughput

0.479

High

648211

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

648213

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

648214

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

648215

ARHG1
Rho guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

648217

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

648218

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

648219

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

648220

OVOL2
Transcription factor Ovo-like 2

1

1

Small-scale

0.479

High

648224

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

648226

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.479

High

648228

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

1

High-throughput

0.479

High

648235

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

648236

INO1
Inositol-3-phosphate synthase 1

1

1

High-throughput

0.479

High

648237

RTN4
Reticulon-4

1

2

High-throughput

0.479

High

648240

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

648246

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

648247

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

648251

NINL
Ninein-like protein

1

4

High-throughput

0.479

High

648258

STRAP
Serine-threonine kinase receptor-associated protein

1

1

High-throughput

0.479

High

248526

O10H3
Olfactory receptor 10H3

1

2

High-throughput

0.470

High

648093

5HT1B
5-hydroxytryptamine receptor 1B

1

1

High-throughput

0.470

High

336348

SVIL
Supervillin

1

0

Small-scale

0.460

High

648186

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

0

High-throughput

0.460

High

128144

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.458

High

129995

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

319398

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

378756

KVD28
Immunoglobulin kappa variable 2D-28

1

0

High-throughput

0.458

High

648099

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

648103

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

648117

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

648122

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

648124

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

648126

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

648139

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

High-throughput

0.458

High

648152

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

0

Small-scale

0.458

High

648154

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

648158

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

648166

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

648177

Q6FHQ0
RBBP7 protein

1

0

High-throughput

0.458

High

648185

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.458

High

648188

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

648225

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

648227

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

648242

HYPK
Huntingtin-interacting protein K

1

0

Small-scale

0.458

High

648253

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

648256

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.458

High

648257

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

648131

RHOB
Rho-related GTP-binding protein RhoB

1

3

Small-scale

0.457

High

648183

TBA1A
Tubulin alpha-1A chain

1

5

High-throughput

0.445

High

648196

CDK20
Cyclin-dependent kinase 20

1

3

High-throughput

0.445

High

648238

S17A5
Sialin

1

2

High-throughput

0.445

High

648252

AMOL2
Angiomotin-like protein 2

1

2

High-throughput

0.445

High

648155

GIT2
ARF GTPase-activating protein GIT2

1

1

High-throughput

0.439

High

105341

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

217832

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

318619

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.437

High

648100

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

648157

RCN2
Reticulocalbin-2

1

6

High-throughput

0.437

High

648190

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

648231

SMOC1
SPARC-related modular calcium-binding protein 1

1

1

High-throughput

0.437

High

648241

OCAD1
OCIA domain-containing protein 1

1

3

High-throughput

0.437

High

648243

Q9NZ23
glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.437

High

648245

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.437

High

648254

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.437

High

648255

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

648141

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

648216

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

648106

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

648202

S15A4
Solute carrier family 15 member 4

1

1

High-throughput

0.407

High

640488

TA2R
Thromboxane A2 receptor

1

0

Small-scale

0.299

High

137651

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.279

Low

648199

ZN843
Zinc finger protein 843

1

0

High-throughput

0.279

Low

648212

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.279

Low

648249

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.279

Low

417948

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

648174

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

648179

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

648182

CEFIP
Cardiac-enriched FHL2-interacting protein

1

0

High-throughput

0.249

Low

648198

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025