HitPredict

Interactor 1: TLX2 (O43763)
T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)
Gene: TLX2

Interactor 2: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 773
+	Hs
		211840 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Hs
		679098 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Hs
		213321 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		211837 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		974243 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		679096 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		213322 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		211839 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		974244 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		679097 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		211838 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE2_HUMAN (8-773): 3.63e-157: 476: 65.19
+	Hs
		213326 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		211844 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		974247 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		213284 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Mm
		223203 TLX3_MOUSE (6-273): 2.36e-41: 146: 57.91		TLE6_MOUSE (474-773): 1.55e-47: 179: 34.64
+	Hs
		211773 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		245566 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		211820 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		WDR5_HUMAN (658-772): 3.81e-36: 141: 21.37
+	Hs
		211960 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TBL1R_HUMAN (651-770): 4.06e-20: 96.4: 13.24