Protein: DCAF6
DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)

Gene: DCAF6
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q58WW2

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157749

DDB1
DNA damage-binding protein 1

7

20

Small-scale

0.965

High

1202203

WDFY3
WD repeat and FYVE domain-containing protein 3

2

18

High-throughput

0.811

High

1202187

DCAF6
DDB1- and CUL4-associated factor 6

2

18

Small-scale

0.754

High

1202233

DDA1
DET1- and DDB1-associated protein 1

2

6

High-throughput

0.754

High

1114867

CUL4A
Cullin-4A

8

20

Small-scale

0.745

High

1115237

CUL4B
Cullin-4B

6

20

Small-scale

0.730

High

848142

MAGA1
Melanoma-associated antigen 1

4

6

High-throughput

0.694

High

1202250

PIHD1
PIH1 domain-containing protein 1

4

3

High-throughput

0.694

High

1202267

NR2E1
Nuclear receptor subfamily 2 group E member 1

4

16

High-throughput

0.694

High

848330

MAGA4
Melanoma-associated antigen 4

4

6

High-throughput

0.691

High

520104

ANDR
Androgen receptor

3

20

Small-scale

0.669

High

1202202

YAF2
YY1-associated factor 2

3

3

High-throughput

0.667

High

1202219

TET5A
Terminal nucleotidyltransferase 5A

3

1

High-throughput

0.667

High

1202228

MDFI
MyoD family inhibitor

3

1

High-throughput

0.653

High

958652

CSN2
COP9 signalosome complex subunit 2

3

14

High-throughput

0.650

High

1202258

VPS28
Vacuolar protein sorting-associated protein 28 homolog

3

0

High-throughput

0.638

High

1202241

PAAT
ATPase PAAT

3

0

High-throughput

0.634

High

679180

DNJB1
DnaJ homolog subfamily B member 1

2

10

High-throughput

0.628

High

404111

GCR
Glucocorticoid receptor

2

20

Small-scale

0.624

High

387118

TNNC2
Troponin C, skeletal muscle

3

0

High-throughput

0.622

High

316880

MTA2
Metastasis-associated protein MTA2

1

4

High-throughput

0.618

High

610695

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

875996

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

957089

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

High-throughput

0.618

High

957412

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.618

High

1034104

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

3

High-throughput

0.618

High

1047911

TLE2
Transducin-like enhancer protein 2

1

18

High-throughput

0.618

High

1050688

DYN1
Dynamin-1

1

1

High-throughput

0.618

High

1098352

ERCC8
DNA excision repair protein ERCC-8

1

18

High-throughput

0.618

High

1132741

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.618

High

1202205

WDTC1
WD and tetratricopeptide repeats protein 1

1

19

High-throughput

0.618

High

1202213

PHIP
PH-interacting protein

1

19

High-throughput

0.618

High

1202217

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.618

High

1202221

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

11

High-throughput

0.618

High

1202229

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

High-throughput

0.618

High

1202232

NUP85
Nuclear pore complex protein Nup85

1

1

High-throughput

0.618

High

1202238

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

20

High-throughput

0.618

High

1202246

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

14

High-throughput

0.618

High

1202204

CLIP4
CAP-Gly domain-containing linker protein 4

2

9

High-throughput

0.614

High

714878

EF1D
Elongation factor 1-delta

2

2

High-throughput

0.611

High

1202247

CABP2
Calcium-binding protein 2

2

2

High-throughput

0.611

High

351855

BMP15
Bone morphogenetic protein 15

3

2

High-throughput

0.609

High

1202234

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

2

High-throughput

0.609

High

1202235

CABP8
Calcium-binding protein 8

3

4

High-throughput

0.604

High

261817

PFD1
Prefoldin subunit 1

2

5

High-throughput

0.601

High

1094347

CSN1
COP9 signalosome complex subunit 1

2

12

High-throughput

0.601

High

1202236

TRI55
Tripartite motif-containing protein 55

2

20

High-throughput

0.586

High

129740

CBX4
E3 SUMO-protein ligase CBX4

2

14

High-throughput

0.584

High

637553

FLNA
Filamin-A

2

15

High-throughput

0.584

High

788674

SRP14
Signal recognition particle 14 kDa protein

2

0

High-throughput

0.576

High

941456

CTBP2
C-terminal-binding protein 2

1

7

High-throughput

0.561

High

1103209

CTBP1
C-terminal-binding protein 1

1

7

High-throughput

0.561

High

213323

ADCY6
Adenylate cyclase type 6

1

1

High-throughput

0.553

High

340447

ADCY5
Adenylate cyclase type 5

1

1

High-throughput

0.553

High

1103758

PLD1
Phospholipase D1

1

2

High-throughput

0.553

High

1195645

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.553

High

1202256

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

1

Small-scale

0.552

High

449651

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.536

High

549175

CDK4
Cyclin-dependent kinase 4

1

9

High-throughput

0.536

High

945652

CABP4
Calcium-binding protein 4

1

2

High-throughput

0.536

High

1022171

DAB2
Disabled homolog 2

1

10

High-throughput

0.536

High

1127649

KT33B
Keratin, type I cuticular Ha3-II

1

9

High-throughput

0.536

High

1132196

CBX2
Chromobox protein homolog 2

1

14

High-throughput

0.536

High

1202200

FMNL3
Formin-like protein 3

1

1

High-throughput

0.536

High

1202227

CSN8
COP9 signalosome complex subunit 8

1

3

High-throughput

0.536

High

1202230

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

1202237

UCK2
Uridine-cytidine kinase 2

1

2

High-throughput

0.536

High

1202249

MYO5C
Unconventional myosin-Vc

1

5

High-throughput

0.536

High

1202259

ING1
Inhibitor of growth protein 1

1

9

High-throughput

0.536

High

1202262

CSN3
COP9 signalosome complex subunit 3

1

13

High-throughput

0.536

High

333481

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.517

High

766613

PHB1
Prohibitin 1

1

9

High-throughput

0.515

High

1202206

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

5

High-throughput

0.515

High

1202224

HPLN3
Hyaluronan and proteoglycan link protein 3

1

1

High-throughput

0.514

High

465848

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

656000

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

1202218

TRI63
E3 ubiquitin-protein ligase TRIM63

1

17

High-throughput

0.508

High

298853

LYZL6
Lysozyme-like protein 6

1

1

High-throughput

0.489

High

709049

NEC1
Neuroendocrine convertase 1

1

3

High-throughput

0.489

High

756553

GALNS
N-acetylgalactosamine-6-sulfatase

1

2

High-throughput

0.489

High

846118

CATO
Cathepsin O

1

1

High-throughput

0.489

High

1108881

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

1

1

High-throughput

0.489

High

1202210

DQX1
ATP-dependent RNA helicase homolog DQX1

1

9

High-throughput

0.489

High

1202212

ITLN1
Intelectin-1

1

2

High-throughput

0.489

High

1202255

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

1

High-throughput

0.489

High

1202261

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.489

High

1202265

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

65842

HMX3
Homeobox protein HMX3

1

3

High-throughput

0.479

High

124792

AIP
AH receptor-interacting protein

1

14

High-throughput

0.479

High

144271

ACACB
Acetyl-CoA carboxylase 2

1

16

High-throughput

0.479

High

154707

ARI1A
AT-rich interactive domain-containing protein 1A

1

13

High-throughput

0.479

High

172896

XPO1
Exportin-1

1

19

High-throughput

0.479

High

182135

PFD6
Prefoldin subunit 6

1

9

High-throughput

0.479

High

276838

VATG1
V-type proton ATPase subunit G 1

1

1

High-throughput

0.479

High

340897

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

7

High-throughput

0.479

High

346643

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.479

High

425914

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

20

High-throughput

0.479

High

446431

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.479

High

455648

KLK3
Prostate-specific antigen

1

3

High-throughput

0.479

High

455792

H10
Histone H1.0

1

1

High-throughput

0.479

High

462882

LAMB1
Laminin subunit beta-1

1

2

High-throughput

0.479

High

464979

SP1
Transcription factor Sp1

1

3

Small-scale

0.479

High

480815

LEG1
Galectin-1

1

6

High-throughput

0.479

High

521727

H14
Histone H1.4

1

11

High-throughput

0.479

High

528269

THIO
Thioredoxin

1

8

High-throughput

0.479

High

547149

PYC
Pyruvate carboxylase, mitochondrial

1

16

High-throughput

0.479

High

556931

MYH7
Myosin-7

1

3

High-throughput

0.479

High

566394

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.479

High

577781

PLAK
Junction plakoglobin

1

10

High-throughput

0.479

High

585792

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

6

High-throughput

0.479

High

587684

DESP
Desmoplakin

1

20

High-throughput

0.479

High

683471

IKBA
NF-kappa-B inhibitor alpha

1

9

High-throughput

0.479

High

838456

GRIA1
Glutamate receptor 1

1

1

High-throughput

0.479

High

868708

LEG7
Galectin-7

1

6

High-throughput

0.479

High

891184

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.479

High

892469

GUAA
GMP synthase [glutamine-hydrolyzing]

1

3

High-throughput

0.479

High

911264

IMA5
Importin subunit alpha-5

1

3

High-throughput

0.479

High

920454

DAPK1
Death-associated protein kinase 1

1

11

High-throughput

0.479

High

922260

LIMK1
LIM domain kinase 1

1

8

High-throughput

0.479

High

943248

RBM11
Splicing regulator RBM11

1

12

High-throughput

0.479

High

963304

PFD3
Prefoldin subunit 3

1

10

High-throughput

0.479

High

965002

WDR5
WD repeat-containing protein 5

1

19

High-throughput

0.479

High

987680

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.479

High

1006077

DLG4
Disks large homolog 4

1

1

High-throughput

0.479

High

1024315

METK1
S-adenosylmethionine synthase isoform type-1

1

2

High-throughput

0.479

High

1029488

SRSF2
Serine/arginine-rich splicing factor 2

1

7

High-throughput

0.479

High

1036737

DSG1
Desmoglein-1

1

4

High-throughput

0.479

High

1038636

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

13

High-throughput

0.479

High

1046371

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.479

High

1048360

ACVR1
Activin receptor type-1

1

5

High-throughput

0.479

High

1051668

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

2

High-throughput

0.479

High

1055812

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.479

High

1094187

ACACA
Acetyl-CoA carboxylase 1

1

16

High-throughput

0.479

High

1099653

GRM1
Metabotropic glutamate receptor 1

1

1

High-throughput

0.479

High

1104593

IKZF1
DNA-binding protein Ikaros

1

7

High-throughput

0.479

High

1110256

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

3

High-throughput

0.479

High

1121412

KEAP1
Kelch-like ECH-associated protein 1

1

4

High-throughput

0.479

High

1129616

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1151251

MED1
Mediator of RNA polymerase II transcription subunit 1

1

10

High-throughput

0.479

High

1158793

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

4

High-throughput

0.479

High

1159501

NTRK2
BDNF/NT-3 growth factors receptor

1

16

High-throughput

0.479

High

1159960

SRSF7
Serine/arginine-rich splicing factor 7

1

17

High-throughput

0.479

High

1165392

KCD19
BTB/POZ domain-containing protein KCTD19

1

3

High-throughput

0.479

High

1202189

PCID2
PCI domain-containing protein 2

1

7

High-throughput

0.479

High

1202190

KPRP
Keratinocyte proline-rich protein

1

2

High-throughput

0.479

High

1202194

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

10

High-throughput

0.479

High

1202195

DCNL2
DCN1-like protein 2

1

1

High-throughput

0.479

High

1202199

NUDC3
NudC domain-containing protein 3

1

15

High-throughput

0.479

High

1202209

CALL6
Calmodulin-like protein 6

1

1

High-throughput

0.479

High

1202211

NUDC2
NudC domain-containing protein 2

1

15

High-throughput

0.479

High

1202214

HXB13
Homeobox protein Hox-B13

1

2

High-throughput

0.479

High

1202215

GLMN
Glomulin

1

2

High-throughput

0.479

High

1202216

KAT5
Histone acetyltransferase KAT5

1

6

High-throughput

0.479

High

1202222

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1202223

NSUN5
28S rRNA

1

4

High-throughput

0.479

High

1202225

DCE1
Glutamate decarboxylase 1

1

2

High-throughput

0.479

High

1202226

PFD5
Prefoldin subunit 5

1

9

High-throughput

0.479

High

1202244

MOV10
Helicase MOV-10

1

5

High-throughput

0.479

High

1202245

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

10

High-throughput

0.479

High

1202248

PFD4
Prefoldin subunit 4

1

6

High-throughput

0.479

High

1202252

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

1202253

NLK
Serine/threonine-protein kinase NLK

1

6

High-throughput

0.479

High

1202254

CSN7A
COP9 signalosome complex subunit 7a

1

8

High-throughput

0.479

High

1202257

PFD2
Prefoldin subunit 2

1

6

High-throughput

0.479

High

1202260

BRPF3
Bromodomain and PHD finger-containing protein 3

1

10

High-throughput

0.479

High

1202264

CDYL
Chromodomain Y-like protein

1

5

High-throughput

0.479

High

186293

PMM2
Phosphomannomutase 2

1

0

High-throughput

0.458

High

339270

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.458

High

446154

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

516764

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

613068

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

713100

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.458

High

832907

CETN2
Centrin-2

1

0

High-throughput

0.458

High

873967

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.458

High

991039

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

1110838

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

0

High-throughput

0.458

High

1163834

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.458

High

1202191

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.458

High

1202192

CPZIP
CapZ-interacting protein

1

0

High-throughput

0.458

High

1202207

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.458

High

1202251

DDIT4
DNA damage-inducible transcript 4 protein

1

0

High-throughput

0.458

High

1202266

ZFP30
Zinc finger protein 30 homolog

1

0

High-throughput

0.458

High

1202242

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

10

High-throughput

0.457

High

430001

JUN
Transcription factor Jun

1

12

High-throughput

0.445

High

766095

PCGF2
Polycomb group RING finger protein 2

1

15

High-throughput

0.445

High

1202196

CSN6
COP9 signalosome complex subunit 6

1

8

High-throughput

0.445

High

533677

CLUS
Clusterin

1

0

High-throughput

0.438

High

1202201

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

353374

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

412046

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.437

High

539673

MBL2
Mannose-binding protein C

1

3

High-throughput

0.437

High

717095

ECHM
Enoyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.437

High

877672

SL9A3
Sodium/hydrogen exchanger 3

1

4

High-throughput

0.437

High

1131502

KCNB1
Potassium voltage-gated channel subfamily B member 1

1

3

High-throughput

0.437

High

1202231

SPON2
Spondin-2

1

1

High-throughput

0.437

High

1202239

TRPV6
Transient receptor potential cation channel subfamily V member 6

1

1

High-throughput

0.437

High

1202240

KCNN2
Small conductance calcium-activated potassium channel protein 2

1

4

High-throughput

0.437

High

1202243

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

2

High-throughput

0.437

High

1202263

ATS8
A disintegrin and metalloproteinase with thrombospondin motifs 8

1

1

High-throughput

0.437

High

224423

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

377253

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

High-throughput

0.407

High

1157360

EXT1
Exostosin-1

1

2

High-throughput

0.407

High

1202198

RIC3
Protein RIC-3

1

1

High-throughput

0.407

High

1202193

FAH2B
Oxaloacetate tautomerase FAHD2B, mitochondrial

1

0

High-throughput

0.279

Low

1202197

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

1202208

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

1202220

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.279

Low

562983

SCG2
Secretogranin-2

1

0

High-throughput

0.269

Low

949250

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.249

Low

1202188

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.249

Low

947007

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025