HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	28805822, 28805820, 29996942, 31776466
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 801
+	Hs
		214273 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		631638 KLH20_HUMAN (134-374): 1.12e-62: 212: 20.75		BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00
+	Hs
		213994 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		245114 KLH20_HUMAN (134-374): 1.12e-62: 212: 20.75		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Dm
		1365592 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q9W1S2_DROME (67-231): 1.86e-38: 146: 25.60
+	Hs
		214386 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		BAZ1A_HUMAN (49-197): 1.07e-22: 106: 21.94
+	Hs
		998693 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Ce
		1089029 MEL26_CAEEL (17-354): 2.9e-71: 229: 31.12		Q17581_CAEEL (78-248): 3.27e-23: 107: 17.71
+	Hs
		1049336 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		BRD7_HUMAN (25-338): 4.42e-29: 125: 17.13
+	Hs
		600141 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		TAF1_HUMAN (64-263): 1.16e-16: 87.2: 16.00