Protein: PKN3
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)

Gene: PKN3
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q6P5Z2

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1160307

RHG26
Rho GTPase-activating protein 26

4

8

Small-scale

0.905

High

900594

RHOA
Transforming protein RhoA

4

20

High-throughput

0.892

High

739994

TGFR2
TGF-beta receptor type-2

3

4

High-throughput

0.861

High

1160248

SKAP1
Src kinase-associated phosphoprotein 1

3

20

High-throughput

0.861

High

49639

RHG10
Rho GTPase-activating protein 10

2

9

Small-scale

0.838

High

66671

ZN785
Zinc finger protein 785

2

1

High-throughput

0.811

High

793112

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

5

High-throughput

0.770

High

1160309

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

2

High-throughput

0.770

High

380120

MAS
Proto-oncogene Mas

2

1

High-throughput

0.726

High

1160243

DEFI8
Differentially expressed in FDCP 8 homolog

2

17

High-throughput

0.726

High

1160261

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.726

High

1032978

PLD1
Phospholipase D1

1

5

Small-scale

0.724

High

118752

AIP
AH receptor-interacting protein

1

8

High-throughput

0.691

High

198913

RFOX2
RNA binding protein fox-1 homolog 2

1

6

High-throughput

0.691

High

431965

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

438275

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

672436

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.691

High

814602

V1BR
Vasopressin V1b receptor

1

4

High-throughput

0.691

High

878680

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

6

High-throughput

0.691

High

1034900

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.691

High

1038890

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

13

High-throughput

0.691

High

1038985

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

10

High-throughput

0.691

High

1039089

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

8

High-throughput

0.691

High

1044918

AVR2B
Activin receptor type-2B

1

4

High-throughput

0.691

High

1048110

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

12

High-throughput

0.691

High

1053027

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

12

High-throughput

0.691

High

1075274

TESK1
Dual specificity testis-specific protein kinase 1

1

2

High-throughput

0.691

High

1082830

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.691

High

1086124

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.691

High

1160255

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

1

High-throughput

0.691

High

1160258

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

1

High-throughput

0.691

High

1160267

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.691

High

1160287

MYO10
Unconventional myosin-X

1

4

High-throughput

0.691

High

1160302

FEM1B
Protein fem-1 homolog B

1

7

High-throughput

0.691

High

1071227

K1H1
Keratin, type I cuticular Ha1

3

13

High-throughput

0.665

High

960629

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.656

High

331387

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

16

High-throughput

0.628

High

1160254

TSYL6
Testis-specific Y-encoded-like protein 6

2

5

High-throughput

0.628

High

648527

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.618

High

1160242

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.618

High

227800

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

411768

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

779613

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

915766

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1050123

GIT2
ARF GTPase-activating protein GIT2

1

12

High-throughput

0.618

High

1160310

GIT1
ARF GTPase-activating protein GIT1

1

12

High-throughput

0.618

High

856543

EFNB2
Ephrin-B2

3

2

High-throughput

0.609

High

994967

GOGA2
Golgin subfamily A member 2

2

9

High-throughput

0.606

High

1127010

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

11

High-throughput

0.606

High

1160252

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

1

High-throughput

0.606

High

1160285

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

204356

MS18B
Protein Mis18-beta

1

0

High-throughput

0.586

High

1123481

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

1123518

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

1078245

EFNB3
Ephrin-B3

2

2

High-throughput

0.574

High

1148919

CYTSA
Cytospin-A

2

8

High-throughput

0.574

High

1160314

PCDGD
Protocadherin gamma-B1

2

2

High-throughput

0.574

High

1160256

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.553

High

1155853

PHLB3
Pleckstrin homology-like domain family B member 3

1

9

High-throughput

0.553

High

1160283

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

129308

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.536

High

151821

IRS4
Insulin receptor substrate 4

1

6

High-throughput

0.536

High

164931

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

281000

KRT38
Keratin, type I cuticular Ha8

1

13

High-throughput

0.536

High

295637

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.536

High

304211

UBR5
E3 ubiquitin-protein ligase UBR5

1

19

High-throughput

0.536

High

308802

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.536

High

335129

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

416647

S10A6
Protein S100-A6

1

7

High-throughput

0.536

High

451914

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.536

High

515883

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

11

High-throughput

0.536

High

614056

TBG1
Tubulin gamma-1 chain

1

13

High-throughput

0.536

High

642954

S10A4
Protein S100-A4

1

7

High-throughput

0.536

High

653290

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.536

High

676914

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

871624

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.536

High

915223

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

11

High-throughput

0.536

High

923712

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.536

High

930890

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

11

High-throughput

0.536

High

946735

TMF1
TATA element modulatory factor

1

8

High-throughput

0.536

High

957861

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

962155

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.536

High

966716

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.536

High

1022829

STRN3
Striatin-3

1

5

High-throughput

0.536

High

1135256

ATD3B
ATPase family AAA domain-containing protein 3B

1

9

High-throughput

0.536

High

1160247

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

7

High-throughput

0.536

High

1160262

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.536

High

1160276

OPALI
Opalin

1

2

High-throughput

0.536

High

1160277

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

1160278

NP1L4
Nucleosome assembly protein 1-like 4

1

5

High-throughput

0.536

High

1160279

TBA1C
Tubulin alpha-1C chain

1

12

High-throughput

0.536

High

1160281

TXNIP
Thioredoxin-interacting protein

1

7

High-throughput

0.536

High

1160284

RPAP3
RNA polymerase II-associated protein 3

1

6

High-throughput

0.536

High

1160288

WDR6
tRNA

1

19

High-throughput

0.536

High

1160298

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.536

High

1160301

KLH21
Kelch-like protein 21

1

3

High-throughput

0.536

High

1160306

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.536

High

1160308

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.536

High

1160312

MYO5A
Unconventional myosin-Va

1

5

High-throughput

0.536

High

154613

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.513

High

180045

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

838912

EMD
Emerin

1

0

High-throughput

0.513

High

943978

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

1032241

CENPR
Centromere protein R

1

0

High-throughput

0.513

High

1160251

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1160253

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1160265

SKA1
Spindle and kinetochore-associated protein 1

1

0

High-throughput

0.513

High

1160271

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.513

High

1160274

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1160292

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.513

High

1160297

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

215456

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.489

High

661307

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

702773

CADH5
Cadherin-5

1

6

High-throughput

0.489

High

740179

NUP62
Nuclear pore glycoprotein p62

1

1

High-throughput

0.489

High

795163

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.489

High

825058

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.489

High

1048750

TRI29
Tripartite motif-containing protein 29

1

8

High-throughput

0.489

High

1102585

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1160250

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.489

High

1160268

I17RA
Interleukin-17 receptor A

1

2

High-throughput

0.489

High

1160294

PCD10
Protocadherin-10

1

3

High-throughput

0.489

High

1160303

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

2

High-throughput

0.489

High

1160305

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.489

High

1160315

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

122207

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

126139

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

8

High-throughput

0.479

High

181535

CLOCK
Circadian locomoter output cycles protein kaput

1

7

High-throughput

0.479

High

215242

STRN
Striatin

1

8

High-throughput

0.479

High

829021

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

882371

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

Small-scale

0.479

High

898143

MAX
Protein max

1

4

High-throughput

0.479

High

1118309

GRAP1
GRIP1-associated protein 1

1

6

High-throughput

0.479

High

1160246

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1160259

GOGA5
Golgin subfamily A member 5

1

9

High-throughput

0.479

High

1160260

CCHCR
Coiled-coil alpha-helical rod protein 1

1

7

High-throughput

0.479

High

1160273

SNX27
Sorting nexin-27

1

16

High-throughput

0.479

High

1160280

NUF2
Kinetochore protein Nuf2

1

6

High-throughput

0.479

High

1160290

HM20A
High mobility group protein 20A

1

8

High-throughput

0.479

High

1160291

BRD7
Bromodomain-containing protein 7

1

10

High-throughput

0.479

High

1160300

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.479

High

1160304

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

1160311

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

317461

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

471611

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

1101119

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1137621

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1157554

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1160245

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.458

High

1160263

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1160266

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1160270

VPS50
Syndetin

1

0

High-throughput

0.458

High

1160275

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.458

High

1160289

TUFT1
Tuftelin

1

0

High-throughput

0.458

High

1160299

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.458

High

497192

TAU
Microtubule-associated protein tau

1

14

Small-scale

0.445

High

787655

PI4KA
Phosphatidylinositol 4-kinase alpha

1

6

High-throughput

0.445

High

1160244

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.445

High

1070125

RABE1
Rab GTPase-binding effector protein 1

1

10

High-throughput

0.437

High

1117754

Q4LE69
1-phosphatidylinositol 4-kinase

1

6

High-throughput

0.437

High

1121520

EIPR1
EARP and GARP complex-interacting protein 1

1

2

High-throughput

0.437

High

1122580

CCD93
Coiled-coil domain-containing protein 93

1

4

High-throughput

0.437

High

1160249

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

12

High-throughput

0.437

High

1160264

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

1160295

HECW2
E3 ubiquitin-protein ligase HECW2

1

16

High-throughput

0.437

High

224971

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1160296

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

118341

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

1140483

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.279

Low

1160257

NGDN
Neuroguidin

1

0

High-throughput

0.279

Low

1160269

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

0

High-throughput

0.279

Low

1160282

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

1160293

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

1160313

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.279

Low

81731

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

1132461

CC122
Coiled-coil domain-containing protein 122

1

0

High-throughput

0.249

Low

1160286

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1160272

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024