Protein: LRP2
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)

Gene: LRP2
Organism: Homo sapiens
Interactions: 145
UniProt ID: P98164

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001822 - kidney development
GO:0001843 - neural tube closure
GO:0003139 - secondary heart field specification
GO:0003148 - outflow tract septum morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720462

AMRP
Alpha-2-macroglobulin receptor-associated protein

5

10

Small-scale

0.928

High

1022643

SOST
Sclerostin

2

6

High-throughput

0.811

High

1022644

PDGFD
Platelet-derived growth factor D

2

5

High-throughput

0.726

High

1022079

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

2

High-throughput

0.691

High

1022624

DLK2
Protein delta homolog 2

1

5

High-throughput

0.691

High

1022629

EGFL6
Epidermal growth factor-like protein 6

1

11

High-throughput

0.691

High

1022633

FGRL1
Fibroblast growth factor receptor-like 1

1

1

High-throughput

0.691

High

167591

GIPC1
PDZ domain-containing protein GIPC1

3

3

Small-scale

0.658

High

533639

CLUS
Clusterin

3

3

Small-scale

0.655

High

366483

UROK
Urokinase-type plasminogen activator

1

11

Small-scale

0.647

High

388843

APOH
Beta-2-glycoprotein 1

1

5

Small-scale

0.647

High

464438

TSP1
Thrombospondin-1

1

6

Small-scale

0.647

High

439701

INSR
Insulin receptor

1

16

High-throughput

0.646

High

1006045

DLG4
Disks large homolog 4

2

8

Small-scale

0.633

High

709292

CCN2
CCN family member 2

2

4

High-throughput

0.628

High

1022636

NET5
Netrin-5

1

11

High-throughput

0.618

High

1022663

DKK2
Dickkopf-related protein 2

1

8

High-throughput

0.618

High

1022669

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.609

High

1022635

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

1022610

RHG19
Rho GTPase-activating protein 19

2

0

High-throughput

0.602

High

1022649

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

961951

RHOA
Transforming protein RhoA

2

12

Small-scale

0.595

High

326251

PRS23
Serine protease 23

1

0

High-throughput

0.586

High

656095

PPIB
Peptidyl-prolyl cis-trans isomerase B

2

0

High-throughput

0.576

High

212804

ZN264
Zinc finger protein 264

2

2

High-throughput

0.574

High

377308

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

2

1

High-throughput

0.574

High

1022626

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.574

High

1022631

ZSC29
Zinc finger and SCAN domain-containing protein 29

2

8

High-throughput

0.574

High

1022650

ZN408
Zinc finger protein 408

2

10

High-throughput

0.574

High

1022660

ZN224
Zinc finger protein 224

2

4

High-throughput

0.574

High

1022147

DAB2
Disabled homolog 2

1

20

Small-scale

0.573

High

1022618

ARH
Low density lipoprotein receptor adapter protein 1

1

20

Small-scale

0.573

High

1022651

ANRA2
Ankyrin repeat family A protein 2

2

5

Small-scale

0.571

High

286357

DAB1
Disabled homolog 1

2

20

Small-scale

0.561

High

1022604

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

20

Small-scale

0.556

High

1022608

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.541

High

480767

LEG1
Galectin-1

1

10

High-throughput

0.536

High

609873

IBP3
Insulin-like growth factor-binding protein 3

1

4

High-throughput

0.536

High

639119

SYT1
Synaptotagmin-1

1

4

High-throughput

0.536

High

1022603

EMX2
Homeobox protein EMX2

1

1

High-throughput

0.536

High

1022609

MAP7
Ensconsin

1

2

High-throughput

0.536

High

1022630

SULF2
Extracellular sulfatase Sulf-2

1

2

High-throughput

0.536

High

1022645

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.536

High

1022665

FBX2
F-box only protein 2

1

7

High-throughput

0.536

High

161564

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.527

High

1022640

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

9

Small-scale

0.527

High

176817

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.513

High

377282

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

0

High-throughput

0.513

High

407846

SEMG1
Semenogelin-1

1

0

High-throughput

0.513

High

647310

IL10
Interleukin-10

1

0

High-throughput

0.513

High

1022605

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1022614

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.513

High

1022622

ALKL2
ALK and LTK ligand 2

1

0

High-throughput

0.513

High

928260

ATN1
Atrophin-1

1

1

High-throughput

0.508

High

387408

APOE
Apolipoprotein E

1

7

Small-scale

0.501

High

421924

A4
Amyloid-beta precursor protein

1

13

Small-scale

0.501

High

449514

LIPL
Lipoprotein lipase

1

6

Small-scale

0.501

High

955056

CDC42
Cell division control protein 42 homolog

1

12

Small-scale

0.501

High

988275

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

Small-scale

0.501

High

1022611

SNX17
Sorting nexin-17

1

4

Small-scale

0.501

High

49560

FEZF1
Fez family zinc finger protein 1

1

13

High-throughput

0.489

High

240145

FGF17
Fibroblast growth factor 17

1

1

High-throughput

0.489

High

517758

GLI4
Zinc finger protein GLI4

1

11

High-throughput

0.489

High

774758

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.489

High

1022623

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

1022625

ZN517
Zinc finger protein 517

1

17

High-throughput

0.489

High

1022632

AN36B
Ankyrin repeat domain-containing protein 36B

1

8

High-throughput

0.489

High

1022638

TAFA4
Chemokine-like protein TAFA-4

1

8

High-throughput

0.489

High

1022647

GREM2
Gremlin-2

1

2

High-throughput

0.489

High

1022659

IL20
Interleukin-20

1

1

High-throughput

0.489

High

269758

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.481

High

944376

SYJ2B
Synaptojanin-2-binding protein

1

17

Small-scale

0.481

High

1022662

LR2BP
LRP2-binding protein

1

2

Small-scale

0.481

High

1022613

DLG2
Disks large homolog 2

1

8

Small-scale

0.481

High

1022627

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

4

Small-scale

0.481

High

1022637

DLG3
Disks large homolog 3

1

8

Small-scale

0.481

High

1022642

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

1022656

SCN3A
Sodium channel protein type 3 subunit alpha

1

3

Small-scale

0.481

High

547951

UTER
Uteroglobin

1

0

Small-scale

0.480

High

189513

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

342157

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

362247

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

375406

RASK
GTPase KRas

1

12

High-throughput

0.479

High

390287

VTDB
Vitamin D-binding protein

1

1

Small-scale

0.479

High

560361

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

561991

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

566633

PDIA4
Protein disulfide-isomerase A4

1

6

High-throughput

0.479

High

601237

RHOQ
Rho-related GTP-binding protein RhoQ

1

15

High-throughput

0.479

High

603930

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630767

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.479

High

631165

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

764660

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

900772

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

901188

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

901768

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

951103

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

956251

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.479

High

976203

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.479

High

1009636

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

Small-scale

0.479

High

1022602

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1022607

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1022612

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

1022621

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1022639

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

1022664

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

1022668

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

1022670

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.479

High

983266

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

1022606

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1022641

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1022648

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

464907

SP1
Transcription factor Sp1

1

11

High-throughput

0.457

High

377250

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

High-throughput

0.445

High

877655

SL9A3
Sodium/hydrogen exchanger 3

1

5

High-throughput

0.445

High

1022615

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.445

High

1022666

S39AA
Zinc transporter ZIP10

1

4

High-throughput

0.445

High

1022655

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

1

Small-scale

0.439

High

1022667

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.439

High

449647

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.437

High

612974

EGR1
Early growth response protein 1

1

9

High-throughput

0.437

High

1022620

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.437

High

1022628

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1022657

OBP2A
Odorant-binding protein 2a

1

1

High-throughput

0.437

High

1022658

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

441475

AGAL
Alpha-galactosidase A

1

0

Small-scale

0.426

High

653253

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

853227

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.407

High

1022654

MEPE
Matrix extracellular phosphoglycoprotein

2

0

High-throughput

0.328

High

1022661

TAP26
Thyroid transcription factor 1-associated protein 26

2

0

High-throughput

0.328

High

1022673

INSL6
Insulin-like peptide INSL6

2

0

High-throughput

0.328

High

1022653

AMBN
Ameloblastin

2

0

High-throughput

0.324

High

1022646

RIBC2
RIB43A-like with coiled-coils protein 2

2

0

High-throughput

0.319

High

852723

VDAC2
Non-selective voltage-gated ion channel VDAC2

2

0

High-throughput

0.313

High

169298

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.279

Low

517648

ZBT48
Zinc finger and BTB domain-containing protein 48

1

0

High-throughput

0.279

Low

1022616

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.279

Low

1022619

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

0

High-throughput

0.279

Low

1022634

DB125
Beta-defensin 125

1

0

High-throughput

0.279

Low

1022652

WFDC1
WAP four-disulfide core domain protein 1

1

0

High-throughput

0.279

Low

482149

RET1
Retinol-binding protein 1

1

0

Small-scale

0.261

Low

187695

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.249

Low

287280

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.249

Low

1022617

RNS13
Probable inactive ribonuclease-like protein 13

1

0

High-throughput

0.249

Low

1022671

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.249

Low

1022672

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025