HitPredict

Interactor 1: MYO1B (O43795)
Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)
Gene: MYO1B

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1136 Hs			1 217
+	Hs
		214469 MYO1B_HUMAN (1-1136): 0: 1188: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		924920 MYO1A_HUMAN (12-1135): 0: 1034: 52.62		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		214472 MYO1B_HUMAN (1-1136): 0: 1188: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		411905 MYO5A_HUMAN (2-1125): 0: 1013: 28.64		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		297270 MYO1D_HUMAN (16-794): 0: 706: 47.73		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		297273 MYO1D_HUMAN (16-794): 0: 706: 47.73		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433732 MYO1E_HUMAN (16-729): 0: 622: 46.27		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		117655 MYO1C_HUMAN (778-1136): 9.49e-71: 259: 25.95		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		117557 MYO1C_HUMAN (778-1136): 9.49e-71: 259: 25.95		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		724756 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		725134 MYH10_HUMAN (771-1132): 7.68e-10: 65.8: 7.47		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		728465 MYH11_HUMAN (701-1112): 2.54e-09: 63.9: 8.28		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		412058 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		111443 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29
+	Hs
		433272 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433620 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47