Protein: MCM4
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)

Gene: MCM4
Organism: Homo sapiens
Interactions: 242
UniProt ID: P33991

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003678 - DNA helicase activity
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

755654

MCM7
DNA replication licensing factor MCM7

19

18

Small-scale

0.985

High

755667

MCM2
DNA replication licensing factor MCM2

12

19

Small-scale

0.977

High

755708

MCM6
DNA replication licensing factor MCM6

12

19

Small-scale

0.976

High

669826

MCM3
DNA replication licensing factor MCM3

5

20

Small-scale

0.922

High

755653

MCM5
DNA replication licensing factor MCM5

2

18

Small-scale

0.789

High

281181

CDC45
Cell division control protein 45 homolog

2

14

Small-scale

0.754

High

755694

SSRP1
FACT complex subunit SSRP1

5

11

Small-scale

0.727

High

755790

CDT1
DNA replication factor Cdt1

1

6

Small-scale

0.724

High

755778

MCMBP
Mini-chromosome maintenance complex-binding protein

4

17

Small-scale

0.717

High

755680

H4
Histone H4

4

7

Small-scale

0.694

High

371302

MYC
Myc proto-oncogene protein

4

5

High-throughput

0.672

High

755744

MCM10
Protein MCM10 homolog

3

12

High-throughput

0.667

High

755765

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.667

High

755802

ASF1B
Histone chaperone ASF1B

3

10

High-throughput

0.667

High

755824

ASF1A
Histone chaperone ASF1A

3

10

Small-scale

0.667

High

755695

EP300
Histone acetyltransferase p300

3

11

Small-scale

0.660

High

755673

PLK1
Serine/threonine-protein kinase PLK1

3

8

Small-scale

0.656

High

755682

H31
Histone H3.1

3

20

High-throughput

0.656

High

132438

CDC7
Cell division cycle 7-related protein kinase

3

17

Small-scale

0.650

High

755812

DBF4A
Protein DBF4 homolog A

3

5

Small-scale

0.650

High

588027

RFA2
Replication protein A 32 kDa subunit

3

5

Small-scale

0.642

High

591502

H2AX
Histone H2AX

2

20

High-throughput

0.628

High

755764

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

8

Small-scale

0.628

High

755827

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

4

Small-scale

0.628

High

230876

ORC5
Origin recognition complex subunit 5

1

20

Small-scale

0.621

High

231451

ORC4
Origin recognition complex subunit 4

1

19

Small-scale

0.621

High

755652

MCM4
DNA replication licensing factor MCM4

1

18

Small-scale

0.621

High

755684

CCNA1
Cyclin-A1

2

3

Small-scale

0.619

High

755691

UBE3A
Ubiquitin-protein ligase E3A

2

9

Small-scale

0.619

High

755777

SLD5
DNA replication complex GINS protein SLD5

1

13

Small-scale

0.618

High

755815

MCM8
DNA helicase MCM8

1

19

Small-scale

0.618

High

755832

ORC6
Origin recognition complex subunit 6

2

4

Small-scale

0.614

High

418855

H2A1B
Histone H2A type 1-B/E

2

20

High-throughput

0.611

High

487005

PARP1
Poly [ADP-ribose] polymerase 1

2

8

High-throughput

0.611

High

755703

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

12

High-throughput

0.611

High

755705

CUL3
Cullin-3

2

6

High-throughput

0.611

High

755761

ING5
Inhibitor of growth protein 5

2

3

Small-scale

0.611

High

755770

TONSL
Tonsoku-like protein

2

9

Small-scale

0.611

High

667580

CDK2
Cyclin-dependent kinase 2

2

10

Small-scale

0.602

High

755831

SP16H
FACT complex subunit SPT16

1

4

Small-scale

0.589

High

694741

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

Small-scale

0.586

High

240887

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

315193

RECQ4
ATP-dependent DNA helicase Q4

2

14

Small-scale

0.584

High

755681

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

755699

TIF1B
Transcription intermediary factor 1-beta

2

16

Small-scale

0.584

High

755746

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

5

High-throughput

0.584

High

755784

FACD2
Fanconi anemia group D2 protein

2

8

Small-scale

0.584

High

755702

ORC2
Origin recognition complex subunit 2

2

8

Small-scale

0.576

High

755690

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

13

High-throughput

0.571

High

755729

ESCO2
N-acetyltransferase ESCO2

1

6

Small-scale

0.552

High

619546

VCAM1
Vascular cell adhesion protein 1

2

7

High-throughput

0.549

High

755774

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

361141

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

362855

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.536

High

455708

H10
Histone H1.0

1

3

High-throughput

0.536

High

484402

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

541852

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.536

High

563301

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

570849

MIF
Macrophage migration inhibitory factor

1

4

High-throughput

0.536

High

601575

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

755662

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

755665

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.536

High

755668

NU153
Nuclear pore complex protein Nup153

1

14

High-throughput

0.536

High

755672

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.536

High

755674

FOXA3
Hepatocyte nuclear factor 3-gamma

1

5

High-throughput

0.536

High

755683

SRPK2
SRSF protein kinase 2

1

9

High-throughput

0.536

High

755686

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

755688

H33
Histone H3.3

1

20

High-throughput

0.536

High

755710

NUMA1
Nuclear mitotic apparatus protein 1

1

14

High-throughput

0.536

High

755723

MK06
Mitogen-activated protein kinase 6

1

12

High-throughput

0.536

High

755724

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.536

High

755725

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

755734

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.536

High

755736

IFIX
Pyrin and HIN domain-containing protein 1

1

4

High-throughput

0.536

High

755749

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.536

High

755760

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.536

High

755773

SRPK1
SRSF protein kinase 1

1

7

High-throughput

0.536

High

755782

CDK19
Cyclin-dependent kinase 19

1

13

High-throughput

0.536

High

755789

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

755798

PAK6
Serine/threonine-protein kinase PAK 6

1

3

High-throughput

0.536

High

755807

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.536

High

226516

TLX2
T-cell leukemia homeobox protein 2

1

0

High-throughput

0.518

High

755671

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

755818

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

443223

CDK1
Cyclin-dependent kinase 1

1

9

Small-scale

0.501

High

755677

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

755696

ILF2
Interleukin enhancer-binding factor 2

1

7

Small-scale

0.500

High

755687

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

755775

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.489

High

755669

DNLI4
DNA ligase 4

1

1

High-throughput

0.481

High

755701

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.481

High

755810

ORC3
Origin recognition complex subunit 3

1

3

Small-scale

0.481

High

61725

SBNO1
Protein strawberry notch homolog 1

1

2

High-throughput

0.479

High

143400

E2F3
Transcription factor E2F3

1

3

Small-scale

0.479

High

157006

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

163059

CHK1
Serine/threonine-protein kinase Chk1

1

4

Small-scale

0.479

High

180724

TIF1A
Transcription intermediary factor 1-alpha

1

19

Small-scale

0.479

High

222759

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

238408

RAD21
Double-strand-break repair protein rad21 homolog

1

3

High-throughput

0.479

High

256783

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

259522

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

293282

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

319450

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324096

CE152
Centrosomal protein of 152 kDa

1

9

High-throughput

0.479

High

324585

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

330696

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

345431

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

376734

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.479

High

395586

ESR1
Estrogen receptor

1

10

High-throughput

0.479

High

411458

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

413290

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

536606

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

539955

BCR
Breakpoint cluster region protein

1

8

High-throughput

0.479

High

550880

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

565186

ITA4
Integrin alpha-4

1

4

High-throughput

0.479

High

606320

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

659375

CRCM
Colorectal mutant cancer protein

1

11

High-throughput

0.479

High

718991

WEE1
Wee1-like protein kinase

1

7

High-throughput

0.479

High

731000

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

754736

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

755655

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

755656

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

755657

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

755658

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

755660

ATRX
Transcriptional regulator ATRX

1

11

Small-scale

0.479

High

755663

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

755664

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

7

High-throughput

0.479

High

755670

EMD
Emerin

1

2

Small-scale

0.479

High

755676

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.479

High

755679

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

755685

RED1
Double-stranded RNA-specific editase 1

1

11

High-throughput

0.479

High

755689

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

755692

SOX4
Transcription factor SOX-4

1

8

High-throughput

0.479

High

755693

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.479

High

755700

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

755704

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

755706

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

755707

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

755709

SMC1A
Structural maintenance of chromosomes protein 1A

1

11

High-throughput

0.479

High

755712

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

755713

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

7

High-throughput

0.479

High

755714

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

755715

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

755716

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

755717

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

755718

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.479

High

755721

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

755722

CRY1
Cryptochrome-1

1

5

High-throughput

0.479

High

755727

CRY2
Cryptochrome-2

1

5

High-throughput

0.479

High

755733

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

755735

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.479

High

755738

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

755740

MMS22
Protein MMS22-like

1

3

Small-scale

0.479

High

755743

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

755745

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

755747

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

10

Small-scale

0.479

High

755748

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

755750

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

755753

SIR6
NAD-dependent protein deacylase sirtuin-6

1

11

High-throughput

0.479

High

755754

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

755757

ABCF1
ATP-binding cassette sub-family F member 1

1

6

High-throughput

0.479

High

755759

TF3C2
General transcription factor 3C polypeptide 2

1

2

High-throughput

0.479

High

755762

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

755763

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

755767

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

755768

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

755772

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

755776

SPI2B
Spindlin-2B

1

3

High-throughput

0.479

High

755779

RN126
E3 ubiquitin-protein ligase RNF126

1

2

High-throughput

0.479

High

755780

DUS23
Dual specificity protein phosphatase 23

1

14

High-throughput

0.479

High

755781

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

17

Small-scale

0.479

High

755783

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.479

High

755786

SPRTN
DNA-dependent metalloprotease SPRTN

1

4

High-throughput

0.479

High

755788

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.479

High

755791

SENP3
Sentrin-specific protease 3

1

2

Small-scale

0.479

High

755793

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

755794

WDR76
WD repeat-containing protein 76

1

12

High-throughput

0.479

High

755795

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

1

High-throughput

0.479

High

755797

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

755799

ANLN
Anillin

1

2

High-throughput

0.479

High

755800

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.479

High

755803

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

2

High-throughput

0.479

High

755804

DONS
Protein downstream neighbor of Son

1

5

Small-scale

0.479

High

755805

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

755806

PD1L1
Programmed cell death 1 ligand 1

1

4

Small-scale

0.479

High

755809

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

6

High-throughput

0.479

High

755811

POLK
DNA polymerase kappa

1

3

Small-scale

0.479

High

755813

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

755814

UBQL2
Ubiquilin-2

1

8

High-throughput

0.479

High

755816

FBW1B
F-box/WD repeat-containing protein 11

1

5

High-throughput

0.479

High

755817

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.479

High

755819

TRI33
E3 ubiquitin-protein ligase TRIM33

1

14

High-throughput

0.479

High

755820

CD11A
Cyclin-dependent kinase 11A

1

10

High-throughput

0.479

High

755821

SMC3
Structural maintenance of chromosomes protein 3

1

11

High-throughput

0.479

High

755822

HDAC5
Histone deacetylase 5

1

11

High-throughput

0.479

High

755823

POLH
DNA polymerase eta

1

3

Small-scale

0.479

High

755825

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

755826

GSTK1
Glutathione S-transferase kappa 1

1

1

High-throughput

0.479

High

755828

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

755830

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

High-throughput

0.479

High

755833

NS1BP
Influenza virus NS1A-binding protein

1

6

High-throughput

0.479

High

642658

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

755659

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

755829

ZN451
E3 SUMO-protein ligase ZNF451

1

0

Small-scale

0.458

High

62458

S35F4
Solute carrier family 35 member F4

1

3

High-throughput

0.445

High

133449

ACATN
Acetyl-coenzyme A transporter 1

1

3

High-throughput

0.445

High

273403

KDM4A
Lysine-specific demethylase 4A

1

7

Small-scale

0.445

High

697015

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.445

High

755678

1433G
14-3-3 protein gamma

1

8

High-throughput

0.445

High

755698

STK4
Serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

755719

NEDD8
Ubiquitin-like protein NEDD8

1

8

Small-scale

0.445

High

755720

UT2
Urea transporter 2

1

1

High-throughput

0.445

High

755730

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

8

Small-scale

0.445

High

755731

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

755756

RN169
E3 ubiquitin-protein ligase RNF169

1

1

Small-scale

0.445

High

755771

S45A3
Solute carrier family 45 member 3

1

3

High-throughput

0.445

High

755785

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

755787

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.445

High

755796

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

243898

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

15

High-throughput

0.437

High

755661

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.437

High

755675

FBXW4
F-box/WD repeat-containing protein 4

1

8

Small-scale

0.437

High

755697

ANK3
Ankyrin-3

1

3

High-throughput

0.437

High

755711

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

3

High-throughput

0.437

High

755726

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

755728

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.437

High

755732

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.437

High

755741

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

755742

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

755751

RHG24
Rho GTPase-activating protein 24

1

10

High-throughput

0.437

High

755752

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

755758

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.437

High

755766

ATG2B
Autophagy-related protein 2 homolog B

1

3

High-throughput

0.437

High

755792

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

755801

DUS22
Dual specificity protein phosphatase 22

1

7

High-throughput

0.437

High

755808

RELCH
RAB11-binding protein RELCH

1

2

High-throughput

0.437

High

755666

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

755739

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

2

Small-scale

0.407

High

755755

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.279

Low

755769

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

755737

FBX46
F-box only protein 46

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025