HitPredict

Interactor 1: AKAP8 (O43823)
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
Gene: AKAP8

Interactor 2: FOXP3 (Q9BZS1)
Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
Gene: FOXP3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0032720 - negative regulation of tumor necrosis factor production GO:0042826 - histone deacetylase binding and 1 others more... GO:0051059 - NF-kappaB binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 692 Hs			1 431
+	Hs
		215681 AKAP8_HUMAN (1-692): 0: 1008: 100.00		FOXC2_HUMAN (297-413): 4.1e-42: 157: 32.79
+	Hs
		215602 AKAP8_HUMAN (1-692): 0: 1008: 100.00		FOXG1_HUMAN (294-426): 1.27e-39: 150: 31.94
+	Hs
		215603 AKAP8_HUMAN (1-692): 0: 1008: 100.00		FOXA3_HUMAN (265-412): 1.3e-38: 144: 23.53
+	Hs
		215698 AKAP8_HUMAN (1-692): 0: 1008: 100.00		FOXJ2_HUMAN (315-429): 2.75e-37: 144: 39.02
+	Mm
		291357 ZN326_MOUSE (127-557): 2.61e-148: 445: 29.33		FOXP3_MOUSE (1-429): 0: 624: 86.51
+	Hs
		1124938 ZN326_HUMAN (127-549): 4.89e-140: 424: 28.70		FOXP3_HUMAN (1-431): 0: 633: 100.00