HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	27365398, 20085707
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 614
+	Mm
		1143001 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		DDX5_MOUSE (1-614): 0: 637: 98.70
+	Hs
		217497 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Mm
		1119393 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		DDX17_MOUSE (30-612): 0: 536: 66.67
+	Hs
		571456 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		571420 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		1059774 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1018621 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		617326 SP100_HUMAN (3-296): 1.81e-36: 146: 13.81		DDX42_HUMAN (16-603): 3.74e-156: 474: 34.09
+	Hs
		1271696 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1059712 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		DDX42_HUMAN (16-603): 3.74e-156: 474: 34.09
+	Hs
		1018563 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		DDX42_HUMAN (16-603): 3.74e-156: 474: 34.09
+	Hs
		134046 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		134003 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Dm
		332736 CHDM_DROME (34-487): 2.06e-20: 97.9: 11.66		DDX17_DROME (2-481): 8.16e-150: 451: 60.87
+	Hs
		134253 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		1059692 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68
+	Hs
		1018549 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68
+	Hs
		331834 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68