Protein: TLN1
Talin-1

Gene: TLN1
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q9Y490

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0001786 - phosphatidylserine binding
GO:0005178 - integrin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424047

ITB3
Integrin beta-3

6

20

Small-scale

0.946

High

431942

ITB1
Integrin beta-1

6

20

Small-scale

0.940

High

613492

VINC
Vinculin

4

18

Small-scale

0.908

High

1491344

TLN2
Talin-2

4

17

High-throughput

0.873

High

1051091

FAK1
Focal adhesion kinase 1

3

20

Small-scale

0.857

High

1214248

KANK4
KN motif and ankyrin repeat domain-containing protein 4

3

18

High-throughput

0.855

High

464088

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

High-throughput

0.778

High

245818

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

6

6

Small-scale

0.726

High

878589

PAXI
Paxillin

4

20

Small-scale

0.696

High

538165

HSP7C
Heat shock cognate 71 kDa protein

4

11

High-throughput

0.683

High

916210

BIEA
Biliverdin reductase A

3

2

High-throughput

0.667

High

1434442

RGCC
Regulator of cell cycle RGCC

3

1

High-throughput

0.667

High

364078

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

411134

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

683633

ITB7
Integrin beta-7

1

20

Small-scale

0.647

High

1406540

DOK1
Docking protein 1

1

4

Small-scale

0.647

High

1178693

RHG31
Rho GTPase-activating protein 31

3

16

High-throughput

0.641

High

247473

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

17

High-throughput

0.618

High

412865

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

557547

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

1125307

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

1434317

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

619968

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.612

High

387926

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.602

High

709033

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

243383

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

346550

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

17

High-throughput

0.584

High

862578

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

1247056

RICTR
Rapamycin-insensitive companion of mTOR

2

4

High-throughput

0.584

High

1063031

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

397304

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1110215

HDAC1
Histone deacetylase 1

2

20

High-throughput

0.571

High

1327820

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.571

High

1439023

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.561

High

935337

TERA
Transitional endoplasmic reticulum ATPase

2

13

High-throughput

0.552

High

1316728

ABI1
Abl interactor 1

1

20

High-throughput

0.541

High

135743

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

250909

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

9

High-throughput

0.536

High

389584

FINC
Fibronectin

1

15

High-throughput

0.536

High

414905

P53
Cellular tumor antigen p53

1

8

High-throughput

0.536

High

530650

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

598279

CL3L1
C-C motif chemokine 3-like 1

1

2

High-throughput

0.536

High

652442

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

856999

BAG6
Large proline-rich protein BAG6

1

12

High-throughput

0.536

High

913624

KIF11
Kinesin-like protein KIF11

1

5

High-throughput

0.536

High

931172

HSP72
Heat shock-related 70 kDa protein 2

1

11

High-throughput

0.536

High

1120407

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

10

High-throughput

0.536

High

1404538

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

1405077

SORT
Sortilin

1

3

High-throughput

0.536

High

1416149

RBM4
RNA-binding protein 4

1

8

High-throughput

0.536

High

1490765

NTNG1
Netrin-G1

1

8

High-throughput

0.536

High

1491346

WIF1
Wnt inhibitory factor 1

1

5

High-throughput

0.536

High

1491347

SAR1B
Small COPII coat GTPase SAR1B

1

18

High-throughput

0.536

High

106906

APRIO
Alternative prion protein

2

10

High-throughput

0.533

High

289193

PRDM1
PR domain zinc finger protein 1

1

2

Small-scale

0.515

High

751353

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

1

High-throughput

0.515

High

946918

H2B1D
Histone H2B type 1-D

1

10

High-throughput

0.515

High

1134778

NUMA1
Nuclear mitotic apparatus protein 1

1

20

High-throughput

0.515

High

1163311

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.515

High

1218044

MYOME
Myomegalin

1

19

High-throughput

0.515

High

347436

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

612025

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

1328329

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1340076

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

High-throughput

0.513

High

1491348

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

869814

MTR1A
Melatonin receptor type 1A

1

7

High-throughput

0.508

High

880988

MTR1B
Melatonin receptor type 1B

1

6

High-throughput

0.508

High

462078

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

691574

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

939991

TPTE
Putative tyrosine-protein phosphatase TPTE

1

8

High-throughput

0.501

High

940362

ITA1
Integrin alpha-1

1

5

Small-scale

0.501

High

1025532

CDK5
Cyclin-dependent kinase 5

1

13

Small-scale

0.501

High

1120656

DAG1
Dystroglycan 1

1

4

Small-scale

0.501

High

1251125

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

8

High-throughput

0.501

High

1259596

TBA1A
Tubulin alpha-1A chain

1

11

Small-scale

0.501

High

1025237

HXC5
Homeobox protein Hox-C5

1

3

High-throughput

0.489

High

1111389

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.489

High

1247650

SAMD1
Sterile alpha motif domain-containing protein 1

1

9

High-throughput

0.489

High

1326698

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

1

High-throughput

0.489

High

1329031

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.489

High

1389529

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

11

High-throughput

0.489

High

1391324

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

1452400

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.489

High

125678

LEG9
Galectin-9

1

2

High-throughput

0.479

High

176237

PER2
Period circadian protein homolog 2

1

9

Small-scale

0.479

High

272574

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

326117

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

Small-scale

0.479

High

335207

ARI2
E3 ubiquitin-protein ligase ARIH2

1

13

Small-scale

0.479

High

353649

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.479

High

387343

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.479

High

401755

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

420749

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.479

High

550540

PABP1
Polyadenylate-binding protein 1

1

3

High-throughput

0.479

High

556439

CADH1
Cadherin-1

1

13

High-throughput

0.479

High

564605

CFTR
Cystic fibrosis transmembrane conductance regulator

1

20

High-throughput

0.479

High

565500

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

607264

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

616245

PGAM1
Phosphoglycerate mutase 1

1

3

High-throughput

0.479

High

623606

RO52
E3 ubiquitin-protein ligase TRIM21

1

13

Small-scale

0.479

High

643158

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

12

High-throughput

0.479

High

665513

EF1B
Elongation factor 1-beta

1

2

High-throughput

0.479

High

668086

CDK2
Cyclin-dependent kinase 2

1

13

High-throughput

0.479

High

714545

PML
Protein PML

1

14

High-throughput

0.479

High

731731

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

765150

CTNB1
Catenin beta-1

1

13

High-throughput

0.479

High

789603

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

799605

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.479

High

831702

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

888415

MCM2
DNA replication licensing factor MCM2

1

13

High-throughput

0.479

High

947324

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.479

High

963553

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

High-throughput

0.479

High

969096

PRS8
26S proteasome regulatory subunit 8

1

4

Small-scale

0.479

High

971347

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

990910

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

995916

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

1051894

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.479

High

1067874

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1085644

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

1107368

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1129400

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

18

Small-scale

0.479

High

1135198

CUL7
Cullin-7

1

12

High-throughput

0.479

High

1137206

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

9

High-throughput

0.479

High

1138808

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.479

High

1146892

PCBP1
Poly(rC)-binding protein 1

1

3

Small-scale

0.479

High

1156913

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

1220906

RN123
E3 ubiquitin-protein ligase RNF123

1

11

High-throughput

0.479

High

1227767

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

1229794

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1247937

ANR12
Ankyrin repeat domain-containing protein 12

1

19

High-throughput

0.479

High

1256235

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1258430

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

1273138

MOB1B
MOB kinase activator 1B

1

5

High-throughput

0.479

High

1280630

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

Small-scale

0.479

High

1289744

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1291310

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

Small-scale

0.479

High

1333380

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

1335102

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1347906

RIN3
Ras and Rab interactor 3

1

13

High-throughput

0.479

High

1350513

BICD2
Protein bicaudal D homolog 2

1

15

High-throughput

0.479

High

1357682

BLNK
B-cell linker protein

1

7

Small-scale

0.479

High

1363906

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1364729

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

1388038

ASB9
Ankyrin repeat and SOCS box protein 9

1

18

High-throughput

0.479

High

1417112

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

18

High-throughput

0.479

High

1417539

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.479

High

1418550

ACE2
Angiotensin-converting enzyme 2

1

4

Small-scale

0.479

High

1429032

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1431146

RBNS5
Rabenosyn-5

1

5

High-throughput

0.479

High

1431360

ATG5
Autophagy protein 5

1

4

High-throughput

0.479

High

1447036

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.479

High

1448259

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1459433

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1459535

TES
Testin

1

19

High-throughput

0.479

High

1462285

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

Small-scale

0.479

High

1491345

ARI1
E3 ubiquitin-protein ligase ARIH1

1

13

Small-scale

0.479

High

1135870

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1249359

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1326958

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

1415083

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.458

High

964521

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.457

High

947383

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

6

Small-scale

0.457

High

1448590

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

133597

ACATN
Acetyl-coenzyme A transporter 1

1

2

High-throughput

0.445

High

404968

PRIO
Major prion protein

1

4

High-throughput

0.445

High

668237

CXCR2
C-X-C chemokine receptor type 2

1

6

Small-scale

0.445

High

766048

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

1209835

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

1235277

NCLX
Mitochondrial sodium/calcium exchanger protein

1

2

High-throughput

0.445

High

1292312

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

1329629

CD177
CD177 antigen

1

1

Small-scale

0.445

High

1391091

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

1395556

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.445

High

1420778

ZDHC5
Palmitoyltransferase ZDHHC5

1

6

High-throughput

0.445

High

1434570

VIAAT
Vesicular inhibitory amino acid transporter

1

1

High-throughput

0.445

High

166720

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

Small-scale

0.437

High

373593

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.437

High

590115

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

685789

U2AF2
Splicing factor U2AF 65 kDa subunit

1

10

High-throughput

0.437

High

696955

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

769599

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

848311

MAGA3
Melanoma-associated antigen 3

1

11

Small-scale

0.437

High

965364

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.437

High

1096877

RFA4
Replication protein A 30 kDa subunit

1

12

High-throughput

0.437

High

1148679

SF3A2
Splicing factor 3A subunit 2

1

9

High-throughput

0.437

High

1150030

TERF2
Telomeric repeat-binding factor 2

1

8

High-throughput

0.437

High

1155943

EZH2
Histone-lysine N-methyltransferase EZH2

1

12

High-throughput

0.437

High

1186164

ANR55
Ankyrin repeat domain-containing protein 55

1

19

High-throughput

0.437

High

1194741

FBX43
F-box only protein 43

1

2

Small-scale

0.437

High

1217935

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

16

Small-scale

0.437

High

1226840

ATG9B
Autophagy-related protein 9B

1

2

Small-scale

0.437

High

1271428

KCTD9
BTB/POZ domain-containing protein KCTD9

1

16

High-throughput

0.437

High

1277019

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1310682

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

7

High-throughput

0.437

High

1352410

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.437

High

1367673

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1419181

STK33
Serine/threonine-protein kinase 33

1

4

High-throughput

0.437

High

1446565

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1461727

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

Small-scale

0.437

High

1462508

TRI33
E3 ubiquitin-protein ligase TRIM33

1

15

Small-scale

0.437

High

1237989

Q6NSK7
RIN3 protein

1

7

High-throughput

0.417

High

62620

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.407

High

653680

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

1259252

NCKX5
Sodium/potassium/calcium exchanger 5

1

2

High-throughput

0.407

High

1325651

SVOPL
Putative transporter SVOPL

1

3

High-throughput

0.407

High

887376

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.373

High

1256820

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

10

High-throughput

0.373

High

1358228

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

1367966

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.279

Low

1032138

FMO1
Flavin-containing monooxygenase 1

1

0

High-throughput

0.261

Low

416055

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.249

Low

635811

PTMS
Parathymosin

1

0

High-throughput

0.249

Low

1136196

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.249

Low

1226561

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1286668

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

High-throughput

0.249

Low

1330451

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1404294

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1180762

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

1330805

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025