HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: H2B1O (P23527)
Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)
Gene: H2BC17

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 126
+	Hs
		217486 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21
+	Hs
		217451 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62
+	Mm
		1145472 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		H2B2B_MOUSE (1-126): 1.28e-55: 171: 98.41
+	Hs
		299044 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41
+	Hs
		299062 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21
+	Hs
		299040 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62
+	Hs
		299075 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2B1A_HUMAN (1-126): 8.17e-48: 151: 85.04
+	Hs
		617953 JADE1_HUMAN (120-523): 6.93e-35: 141: 12.28		H2B1O_HUMAN (1-126): 1.76e-55: 170: 100.00
+	Hs
		1087195 JADE1_HUMAN (120-523): 6.93e-35: 141: 12.28		H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21
+	Hs
		1059648 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21
+	Hs
		1059777 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21
+	Hs
		918368 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41
+	Hs
		241527 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1K_HUMAN (1-126): 1.05e-54: 168: 97.62
+	Hs
		707635 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62
+	Hs
		886109 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1D_HUMAN (1-126): 2.25e-54: 168: 97.62
+	Hs
		1059827 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1L_HUMAN (1-126): 2.06e-53: 165: 96.83
+	Hs
		241591 CHD5_HUMAN (288-504): 6.06e-28: 121: 17.41		H2B1K_HUMAN (1-126): 1.05e-54: 168: 97.62
+	Hs
		1059782 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2B1A_HUMAN (1-126): 8.17e-48: 151: 85.04
+	Sc
		356010 RCO1_YEAST (143-476): 9.27e-35: 140: 14.89		H2B2_YEAST (3-125): 3.09e-41: 134: 71.55
+	Sc
		355636 RCO1_YEAST (143-476): 9.27e-35: 140: 14.89		H2B1_YEAST (4-125): 7.99e-37: 123: 72.13