HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 904
+	Mm
		956200 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		MCM2_MOUSE (1-904): 0: 1058: 95.58
+	Hs
		832409 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		217452 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		832782 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		170301 TIF1A_HUMAN (421-491): 1.58e-13: 75.6: 29.58		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Mm
		831956 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		MCM5_MOUSE (169-902): 0: 764: 29.30
+	Hs
		217480 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Mm
		956211 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		MCM6_MOUSE (186-817): 0: 713: 30.88
+	Hs
		708544 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		170275 TIF1A_HUMAN (421-491): 1.58e-13: 75.6: 29.58		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708618 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		627266 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		627336 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		627247 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		709005 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Hs
		1055555 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		708880 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Hs
		1055657 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		709113 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Hs
		170276 TIF1A_HUMAN (421-491): 1.58e-13: 75.6: 29.58		MCM7_HUMAN (188-886): 0: 707: 27.35