HitPredict

Interactor 1: ITB3 (O54890)
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Gene: Itgb3

Interactor 2: FLNA (Q8BTM8)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30333137
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filamin~Integrin_b_cyt
Common GO terms	GO:0005080 - protein kinase C binding GO:0005634 - nucleus GO:0005911 - cell-cell junction GO:0098978 - glutamatergic synapse GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 787 Mm			1 2647
+	Mm
		447108 ITB1_MOUSE (10-786): 0: 733: 43.27		FLNA_MOUSE (1-2647): 0: 2466: 100.00
+	Hs
		396566 ITB3_HUMAN (1-787): 0: 763: 90.61		FLNA_HUMAN (1-2647): 0: 2433: 97.32
+	Hs
		403783 ITB1_HUMAN (10-786): 0: 728: 43.52		FLNA_HUMAN (1-2647): 0: 2433: 97.32
+	Mm
		222550 ITB3_MOUSE (1-787): 0: 793: 100.00		FLNB_MOUSE (28-2647): 0: 2354: 68.56
+	Hs
		261179 ITB3_HUMAN (1-787): 0: 763: 90.61		FLNB_HUMAN (28-2647): 0: 2378: 69.17
+	Hs
		577567 ITB6_HUMAN (30-785): 0: 692: 49.87		FLNA_HUMAN (1-2647): 0: 2433: 97.32
+	Hs
		261181 ITB1_HUMAN (10-786): 0: 728: 43.52		FLNB_HUMAN (28-2647): 0: 2378: 69.17
+	Mm
		515666 ITB2_MOUSE (24-785): 0: 625: 38.45		FLNA_MOUSE (1-2647): 0: 2466: 100.00
+	Hs
		261196 ITB6_HUMAN (30-785): 0: 692: 49.87		FLNB_HUMAN (28-2647): 0: 2378: 69.17
+	Hs
		597965 ITB7_HUMAN (31-785): 0: 637: 38.82		FLNA_HUMAN (1-2647): 0: 2433: 97.32
+	Mm
		515662 ITB2_MOUSE (24-785): 0: 625: 38.45		FLNB_MOUSE (28-2647): 0: 2354: 68.56
+	Mm
		222569 ITB3_MOUSE (1-787): 0: 793: 100.00		FLNC_MOUSE (8-2647): 0: 1231: 35.48
+	Mm
		515676 ITB2_MOUSE (24-785): 0: 625: 38.45		FLNC_MOUSE (8-2647): 0: 1231: 35.48
+	Mm
		222535 ITB3_MOUSE (1-787): 0: 793: 100.00		SPTB2_MOUSE (1-389): 3.18e-111: 400: 26.50
+	Gg
		396530 ITB1_CHICK (8-786): 0: 729: 43.23		ACTN1_CHICK (20-390): 3.59e-122: 412: 25.07
+	Hs
		403752 ITB1_HUMAN (10-786): 0: 728: 43.52		ACTN1_HUMAN (20-390): 9.91e-122: 411: 25.07
+	Rn
		88558 ITB1_RAT (10-786): 0: 726: 43.09		D3ZCV0_RAT (25-390): 1.03e-113: 387: 25.93
+	Mm
		447075 ITB1_MOUSE (10-786): 0: 733: 43.27		ACTN4_MOUSE (24-268): 1.36e-104: 361: 35.74
+	Mm
		515654 ITB2_MOUSE (24-785): 0: 625: 38.45		SPTB2_MOUSE (1-389): 3.18e-111: 400: 26.50
+	Hs
		574558 ITB5_HUMAN (4-787): 0: 710: 53.63		TITIN_HUMAN (993-1248): 7.94e-12: 74: 11.00