Protein: RRP44
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)

Gene: RRP44, DIS3
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9Y2L1

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1284999

EXOS8
Exosome complex component RRP43

2

19

Small-scale

0.806

High

1342631

EXOS4
Exosome complex component RRP41

1

19

Small-scale

0.715

High

986739

EXOS9
Exosome complex component RRP45

1

20

Small-scale

0.691

High

1063785

EXOS7
Exosome complex component RRP42

1

19

Small-scale

0.691

High

1343596

EXOS5
Exosome complex component RRP46

1

20

Small-scale

0.691

High

966507

EXOSX
Exosome complex component 10

4

5

Small-scale

0.687

High

1198932

RBM23
Probable RNA-binding protein 23

3

2

High-throughput

0.667

High

1343615

EXOS3
Exosome complex component RRP40

3

4

Small-scale

0.657

High

208309

DCX
Neuronal migration protein doublecortin

3

0

High-throughput

0.638

High

1314914

SSBP3
Single-stranded DNA-binding protein 3

3

0

High-throughput

0.638

High

1047042

C1D
Nuclear nucleic acid-binding protein C1D

2

1

High-throughput

0.628

High

1298954

MUS81
Crossover junction endonuclease MUS81

2

1

High-throughput

0.628

High

1046361

EXOS2
Exosome complex component RRP4

2

5

Small-scale

0.628

High

1042880

CUL3
Cullin-3

2

1

High-throughput

0.611

High

1261513

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1273362

DLX4
Homeobox protein DLX-4

2

0

High-throughput

0.602

High

577786

NELFE
Negative elongation factor E

2

0

High-throughput

0.585

High

348288

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

387776

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

1377303

RRP44
Exosome complex exonuclease RRP44

1

5

Small-scale

0.575

High

229106

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1234585

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

258253

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

636452

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

853760

IMA5
Importin subunit alpha-5

1

2

High-throughput

0.536

High

1067260

WDR43
WD repeat-containing protein 43

1

4

High-throughput

0.536

High

1216465

RBM45
RNA-binding protein 45

1

2

High-throughput

0.536

High

1230255

EID3
EP300-interacting inhibitor of differentiation 3

1

1

High-throughput

0.536

High

1274085

CUL5
Cullin-5

1

1

High-throughput

0.536

High

1284849

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1304456

MPH6
M-phase phosphoprotein 6

1

1

High-throughput

0.536

High

1377305

EXOS1
Exosome complex component CSL4

1

10

Small-scale

0.536

High

1130744

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

146655

SOCS2
Suppressor of cytokine signaling 2

1

1

High-throughput

0.515

High

147578

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.515

High

149939

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

273311

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

278682

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

664145

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

885849

MTPN
Myotrophin

1

0

High-throughput

0.513

High

1134955

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1145674

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

1219127

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1223368

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.513

High

1241076

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1244192

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

0

High-throughput

0.513

High

1271381

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1304363

SORT
Sortilin

1

0

High-throughput

0.513

High

1311371

PIMRE
Protein PIMREG

1

0

High-throughput

0.513

High

1314514

YJU2
Splicing factor YJU2

1

0

High-throughput

0.513

High

1318341

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1318432

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1332135

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1336373

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

1342734

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1346450

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1347857

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.513

High

1354491

ZN212
Zinc finger protein 212

1

0

High-throughput

0.513

High

1357711

TRI35
E3 ubiquitin-protein ligase TRIM35

1

0

High-throughput

0.513

High

1377307

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

999699

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

1068707

PLEC
Plectin

1

0

High-throughput

0.493

High

1347526

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

1377259

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

1024305

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

High-throughput

0.486

High

1313588

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.486

High

245113

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

304403

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

Small-scale

0.479

High

323334

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

360557

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

669087

PML
Protein PML

1

1

High-throughput

0.479

High

787037

MTREX
Exosome RNA helicase MTR4

1

7

Small-scale

0.479

High

828063

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

960351

CDK5
Cyclin-dependent kinase 5

1

3

High-throughput

0.479

High

999235

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1054684

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1064859

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1080999

SEPT7
Septin-7

1

1

High-throughput

0.479

High

1085554

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

1146982

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1307065

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1326855

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.479

High

1344544

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1357687

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

1377138

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.479

High

1377304

SHLB1
Endophilin-B1

1

1

High-throughput

0.479

High

231890

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

262625

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

339168

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

504989

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

554096

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

570199

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

607741

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

652652

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

685125

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

719248

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

721824

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

738427

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

742621

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

824553

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

867273

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

902387

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.458

High

909355

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

948917

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

1019183

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1036223

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1049192

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1101386

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1163913

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1200775

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1270101

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

1281493

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1286258

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

1313519

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

1315552

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1316833

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1327159

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1330198

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

1335407

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.458

High

1345161

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

1349045

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1349395

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1354917

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1355081

TES
Testin

1

0

High-throughput

0.458

High

217965

PRKY
Putative serine/threonine-protein kinase PRKY

1

1

High-throughput

0.445

High

402647

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1344857

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

122274

RN103
E3 ubiquitin-protein ligase RNF103

1

1

High-throughput

0.437

High

385754

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1172343

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1300032

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.437

High

1331670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1346422

SEP11
Septin-11

1

1

High-throughput

0.437

High

349745

RASH
GTPase HRas

1

0

High-throughput

0.426

High

1057732

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1304290

GA2L1
GAS2-like protein 1

3

0

High-throughput

0.347

High

361952

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

397080

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.328

High

388914

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

60172

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.279

Low

441044

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.279

Low

1236203

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1238310

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1238793

F181A
Protein FAM181A

1

0

High-throughput

0.279

Low

1285038

ZN428
Zinc finger protein 428

1

0

High-throughput

0.279

Low

1291034

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

1302196

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1357835

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.279

Low

1377306

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

48031

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.249

Low

101301

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

674571

UFO
Tyrosine-protein kinase receptor UFO

1

0

High-throughput

0.249

Low

1159548

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.249

Low

1231377

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1239350

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1252250

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1292367

RN185
E3 ubiquitin-protein ligase RNF185

1

0

High-throughput

0.249

Low

1294147

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1355346

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024