HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SRBS1 (Q62417)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: Sorbs1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11557983
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0045202 - synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Mm			1 1290
+	Hs
		208967 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		SRBS2_HUMAN (133-1288): 2.01e-124: 414: 25.94
+	Hs
		209154 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		SRBS1_HUMAN (1-1290): 1.07e-39: 163: 21.55
+	Hs
		235470 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		VINEX_HUMAN (812-1288): 3.2e-43: 170: 31.19
+	Hs
		208958 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		NCK2_HUMAN (973-1208): 5.89e-20: 95.7: 20.97
+	Hs
		3133 A0A0S2Z4D7_HUMAN (1-138): 3.25e-60: 193: 67.39		VINEX_HUMAN (812-1288): 3.2e-43: 170: 31.19
+	Hs
		208989 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		NCK1_HUMAN (1129-1285): 3.56e-09: 62.4: 31.48
+	Hs
		557655 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		GRB2_HUMAN (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		557594 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		NCK1_HUMAN (1129-1285): 3.56e-09: 62.4: 31.48
+	Ce
		711210 Q95PW9_CAEEL (1-379): 1.05e-70: 228: 38.38		YKA7_CAEEL (957-1286): 3.18e-21: 101: 18.73
+	Hs
		1349275 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		ITSN2_HUMAN (474-1288): 1.49e-32: 140: 10.57
+	Hs
		548645 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		VAV_HUMAN (557-1289): 1.58e-33: 142: 11.16
+	Hs
		580936 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		PLCG1_HUMAN (1175-1288): 7.56e-15: 82: 22.81
+	Hs
		1285205 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		SH3K1_HUMAN (1022-1109): 7.84e-12: 71.8: 27.10
+	Mm
		643091 P85A_MOUSE (24-379): 1.32e-31: 128: 12.57		GRB2_MOUSE (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		655306 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		GRB2_HUMAN (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		1078919 ITSN2_HUMAN (5-300): 7.23e-34: 135: 18.60		ITSN1_HUMAN (822-1288): 3.63e-10: 67: 11.75
+	Hs
		655439 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		SH3K1_HUMAN (1022-1109): 7.84e-12: 71.8: 27.10
+	Hs
		655386 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		ITSN1_HUMAN (822-1288): 3.63e-10: 67: 11.75
+	Hs
		557615 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		NCK1_HUMAN (1129-1285): 3.56e-09: 62.4: 31.48