Protein: MRCKB
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)

Gene: MRCKB, CDC42BPB
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9Y5S2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955794

CDC42
Cell division control protein 42 homolog

4

20

High-throughput

0.900

High

1217577

MRCKA
Serine/threonine-protein kinase MRCK alpha

3

19

High-throughput

0.864

High

720644

GRPR
Gastrin-releasing peptide receptor

2

1

High-throughput

0.811

High

1051346

KPCZ
Protein kinase C zeta type

2

11

High-throughput

0.811

High

1449543

INKA2
PAK4-inhibitor INKA2

3

1

High-throughput

0.770

High

376146

RASK
GTPase KRas

2

20

High-throughput

0.754

High

978431

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1097128

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.698

High

1109692

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

14

High-throughput

0.698

High

1135614

UBX2B
UBX domain-containing protein 2B

4

1

High-throughput

0.694

High

995370

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.691

High

777036

PPM1A
Protein phosphatase 1A

1

6

Small-scale

0.647

High

1397268

LURA1
Leucine rich adaptor protein 1

3

8

Small-scale

0.643

High

1396469

F167A
Protein FAM167A

4

2

High-throughput

0.636

High

126895

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

175956

SET1A
Histone-lysine N-methyltransferase SETD1A

1

9

High-throughput

0.618

High

374305

RASN
GTPase NRas

1

20

High-throughput

0.618

High

401772

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.618

High

412892

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.618

High

440262

LCK
Tyrosine-protein kinase Lck

1

13

High-throughput

0.618

High

463865

LYN
Tyrosine-protein kinase Lyn

1

13

High-throughput

0.618

High

465061

SP1
Transcription factor Sp1

1

5

Small-scale

0.618

High

573739

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

581399

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601518

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

659070

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

2

High-throughput

0.618

High

845876

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

910271

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953780

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962678

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962870

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988860

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015942

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1040958

MECOM
Histone-lysine N-methyltransferase MECOM

1

6

High-throughput

0.618

High

1145196

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

1146500

KS6A2
Ribosomal protein S6 kinase alpha-2

1

13

High-throughput

0.618

High

1151950

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1161809

CDKN3
Cyclin-dependent kinase inhibitor 3

1

2

Small-scale

0.618

High

1253253

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

8

High-throughput

0.618

High

1256282

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1271069

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1396668

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1416710

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.618

High

1433022

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.618

High

1433601

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1434353

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1438271

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1458572

HDAC6
Protein deacetylase HDAC6

2

9

High-throughput

0.611

High

1308141

LUR1L
Leucine rich adaptor protein 1-like

3

8

High-throughput

0.609

High

1365629

MY18A
Unconventional myosin-XVIIIa

2

17

Small-scale

0.601

High

255338

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.575

High

564617

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.575

High

1288959

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

3

High-throughput

0.575

High

397329

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

1250224

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.553

High

944171

WDR4
tRNA

1

10

High-throughput

0.541

High

190527

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.536

High

355117

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

13

High-throughput

0.536

High

704563

RXRB
Retinoic acid receptor RXR-beta

1

11

High-throughput

0.536

High

916729

PPP5
Serine/threonine-protein phosphatase 5

1

8

High-throughput

0.536

High

1144237

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1328704

KCD17
BTB/POZ domain-containing protein KCTD17

1

12

High-throughput

0.536

High

1462533

TRI35
E3 ubiquitin-protein ligase TRIM35

1

8

High-throughput

0.536

High

539650

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.518

High

810488

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.515

High

1010739

DCD
Dermcidin

1

1

High-throughput

0.515

High

1372353

H2B1H
Histone H2B type 1-H

1

17

High-throughput

0.515

High

1400356

FMNL2
Formin-like protein 2

1

3

High-throughput

0.515

High

1411940

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.513

High

1438308

BEX1
Protein BEX1

1

0

High-throughput

0.513

High

994436

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

Small-scale

0.501

High

1328157

TTC9C
Tetratricopeptide repeat protein 9C

1

9

High-throughput

0.489

High

1391987

FA89A
Protein FAM89A

1

1

High-throughput

0.489

High

299447

FLOT1
Flotillin-1

1

7

High-throughput

0.479

High

331450

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.479

High

346567

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

604289

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

693152

DPP4
Dipeptidyl peptidase 4

1

3

High-throughput

0.479

High

791879

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

842614

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

946941

H2B1D
Histone H2B type 1-D

1

17

High-throughput

0.479

High

1024968

VIGLN
Vigilin

1

10

High-throughput

0.479

High

1058965

ZO1
Tight junction protein 1

1

12

Small-scale

0.479

High

1114773

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1142045

EEA1
Early endosome antigen 1

1

17

High-throughput

0.479

High

1159921

OCLN
Occludin

1

3

High-throughput

0.479

High

1277044

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1291024

TAXB1
Tax1-binding protein 1

1

18

High-throughput

0.479

High

1323698

K2C78
Keratin, type II cytoskeletal 78

1

3

High-throughput

0.479

High

1326526

ARL14
ADP-ribosylation factor-like protein 14

1

11

High-throughput

0.479

High

1367697

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1380296

FBXW7
F-box/WD repeat-containing protein 7

1

10

High-throughput

0.479

High

1382020

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1447884

DDX21
Nucleolar RNA helicase 2

1

15

High-throughput

0.479

High

1453908

H2AW
Core histone macro-H2A.2

1

17

High-throughput

0.479

High

1459470

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1490431

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

3

High-throughput

0.479

High

1351508

BRX1
Ribosome biogenesis protein BRX1 homolog

1

4

High-throughput

0.470

High

711751

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.458

High

1386505

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.458

High

1448602

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

906377

GPC3
Glypican-3

1

3

High-throughput

0.445

High

942983

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.445

High

1208915

H2B2F
Histone H2B type 2-F

1

17

High-throughput

0.445

High

1226340

CP135
Centrosomal protein of 135 kDa

1

17

High-throughput

0.445

High

1326181

RYBP
RING1 and YY1-binding protein

1

6

High-throughput

0.445

High

1458887

SL9A2
Sodium/hydrogen exchanger 2

1

4

High-throughput

0.445

High

106929

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

590146

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

769630

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1380338

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.249

Low

1462342

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025