HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PP6R2 (O75170)
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)
Gene: PPP6R2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 966
+	Hs
		227666 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PP6R3_HUMAN (1-914): 0: 746: 46.31
+	Hs
		475872 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP6R3_HUMAN (1-914): 0: 746: 46.31
+	Hs
		476577 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PP6R1_HUMAN (1-898): 0: 640: 39.94
+	Hs
		227915 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HUWE1_HUMAN (487-954): 7.07e-26: 118: 13.22
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (606-965): 2.28e-09: 63.9: 10.35
+	Hs
		228928 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGFR_HUMAN (684-963): 4.67e-09: 62.3: 11.77
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (591-907): 3.94e-09: 63.1: 9.76
+	Sc
		477227 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SA190_YEAST (44-741): 1.71e-44: 176: 13.57
+	Sc
		477322 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SA185_YEAST (365-717): 5.56e-41: 165: 14.25
+	Hs
		475080 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		HUWE1_HUMAN (487-954): 7.07e-26: 118: 13.22
+	Hs
		312672 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGFR_HUMAN (684-963): 4.67e-09: 62.3: 11.77
+	Hs
		475984 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HUWE1_HUMAN (487-954): 7.07e-26: 118: 13.22
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (600-961): 3.78e-19: 95.8: 9.12
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (593-858): 6.06e-11: 68.9: 7.90