Protein: STX8
Syntaxin-8

Gene: STX8
Organism: Homo sapiens
Interactions: 236
UniProt ID: Q9UNK0

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005484 - SNAP receptor activity
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1459042

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

11

20

Small-scale

0.979

High

189928

STX7
Syntaxin-7

8

20

Small-scale

0.966

High

1294863

STX12
Syntaxin-12

6

20

High-throughput

0.945

High

933073

SNAA
Alpha-soluble NSF attachment protein

5

20

Small-scale

0.927

High

1087341

STX4
Syntaxin-4

4

20

High-throughput

0.909

High

278580

VAMP4
Vesicle-associated membrane protein 4

4

20

Small-scale

0.909

High

1414891

VAMP8
Vesicle-associated membrane protein 8

4

20

Small-scale

0.909

High

1154785

VAMP3
Vesicle-associated membrane protein 3

4

20

Small-scale

0.903

High

328761

VAMP5
Vesicle-associated membrane protein 5

4

20

High-throughput

0.902

High

908065

VAMP7
Vesicle-associated membrane protein 7

4

20

Small-scale

0.895

High

1100738

STX3
Syntaxin-3

4

20

High-throughput

0.892

High

226263

STX6
Syntaxin-6

3

14

High-throughput

0.861

High

1383316

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

3

20

Small-scale

0.861

High

1407057

SNAG
Gamma-soluble NSF attachment protein

3

20

High-throughput

0.861

High

1097923

STX5
Syntaxin-5

3

20

High-throughput

0.858

High

286739

STX11
Syntaxin-11

3

20

High-throughput

0.855

High

280371

SC22B
Vesicle-trafficking protein SEC22b

2

20

High-throughput

0.811

High

1358400

SCFD1
Sec1 family domain-containing protein 1

2

17

High-throughput

0.811

High

746228

STX2
Syntaxin-2

2

20

High-throughput

0.783

High

1159659

STX1A
Syntaxin-1A

2

20

High-throughput

0.783

High

1281208

CPLX4
Complexin-4

2

0

High-throughput

0.742

High

1339582

STXB6
Syntaxin-binding protein 6

2

4

High-throughput

0.726

High

160348

GOSR2
Golgi SNAP receptor complex member 2

1

20

High-throughput

0.691

High

192343

YKT6
Synaptobrevin homolog YKT6

1

20

High-throughput

0.691

High

249913

STX10
Syntaxin-10

1

15

High-throughput

0.691

High

331933

GOSR1
Golgi SNAP receptor complex member 1

1

8

High-throughput

0.691

High

989398

VAMP2
Vesicle-associated membrane protein 2

1

20

High-throughput

0.691

High

1448943

VPS45
Vacuolar protein sorting-associated protein 45

1

17

High-throughput

0.691

High

1208764

CL12A
C-type lectin domain family 12 member A

3

6

High-throughput

0.667

High

1366305

LPAR1
Lysophosphatidic acid receptor 1

3

1

High-throughput

0.667

High

1454889

STX18
Syntaxin-18

3

6

High-throughput

0.667

High

1093603

TRDN
Triadin

3

4

High-throughput

0.662

High

1129910

EPN4
Clathrin interactor 1

3

4

High-throughput

0.662

High

1355948

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

2

High-throughput

0.662

High

230467

CREB3
Cyclic AMP-responsive element-binding protein 3

3

3

High-throughput

0.658

High

189037

TMPS2
Transmembrane protease serine 2

3

2

High-throughput

0.653

High

166449

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

3

13

High-throughput

0.643

High

1462330

SRPRB
Signal recognition particle receptor subunit beta

4

7

High-throughput

0.638

High

1386746

AP2M1
AP-2 complex subunit mu

3

0

High-throughput

0.638

High

1389812

DTBP1
Dysbindin

3

0

High-throughput

0.638

High

1339412

GP156
Probable G-protein coupled receptor 156

3

0

High-throughput

0.634

High

343504

SNP29
Synaptosomal-associated protein 29

2

20

High-throughput

0.628

High

857202

NSF
Vesicle-fusing ATPase

2

9

High-throughput

0.628

High

940576

AP1S2
AP-1 complex subunit sigma-2

2

4

High-throughput

0.628

High

1086142

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

2

High-throughput

0.628

High

1358039

TM171
Transmembrane protein 171

3

1

High-throughput

0.609

High

167024

MGST3
Glutathione S-transferase 3, mitochondrial

2

2

High-throughput

0.606

High

194764

FFAR2
Free fatty acid receptor 2

2

2

High-throughput

0.606

High

338266

CLD9
Claudin-9

2

1

High-throughput

0.606

High

349643

TSN12
Tetraspanin-12

2

3

High-throughput

0.606

High

456029

ASGR2
Asialoglycoprotein receptor 2

2

6

High-throughput

0.606

High

549919

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.606

High

870810

CXA8
Gap junction alpha-8 protein

2

6

High-throughput

0.606

High

1102469

BIK
Bcl-2-interacting killer

2

1

High-throughput

0.606

High

1142973

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

1

High-throughput

0.606

High

1186071

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.606

High

1242821

RNK
Ribonuclease kappa

2

1

High-throughput

0.606

High

1326951

EMC5
ER membrane protein complex subunit 5

2

2

High-throughput

0.606

High

1328225

JAGN1
Protein jagunal homolog 1

2

1

High-throughput

0.606

High

1351727

GP152
Probable G-protein coupled receptor 152

2

3

High-throughput

0.606

High

1351769

GP151
G-protein coupled receptor 151

2

2

High-throughput

0.606

High

1384380

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.606

High

1400570

TM237
Transmembrane protein 237

2

1

High-throughput

0.606

High

1406945

MGST2
Microsomal glutathione S-transferase 2

2

2

High-throughput

0.606

High

1447914

SAR1A
Small COPII coat GTPase SAR1A

2

9

High-throughput

0.606

High

1452328

SCN3B
Sodium channel regulatory subunit beta-3

2

3

High-throughput

0.606

High

1462326

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

2

High-throughput

0.606

High

1462331

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

1

High-throughput

0.606

High

1390688

STALP
AMSH-like protease

2

0

High-throughput

0.602

High

508833

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.595

High

631021

RAB4A
Ras-related protein Rab-4A

2

9

High-throughput

0.584

High

902143

RAB9A
Ras-related protein Rab-9A

2

12

High-throughput

0.584

High

951523

SC61B
Protein transport protein Sec61 subunit beta

2

2

High-throughput

0.584

High

337842

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.580

High

1158747

KCMB1
Calcium-activated potassium channel subunit beta-1

2

0

High-throughput

0.580

High

1193255

CLM2
CMRF35-like molecule 2

2

0

High-throughput

0.580

High

1228660

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

0

High-throughput

0.580

High

1281771

T179B
Transmembrane protein 179B

2

0

High-throughput

0.580

High

1361966

BSND
Barttin

2

0

High-throughput

0.580

High

1393281

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

0

High-throughput

0.580

High

91883

C9JXZ5
Vesicle associated membrane protein 8

1

20

High-throughput

0.575

High

1403232

MA7D2
MAP7 domain-containing protein 2

2

6

High-throughput

0.574

High

1211032

CE170
Centrosomal protein of 170 kDa

2

1

High-throughput

0.558

High

464726

CXB1
Gap junction beta-1 protein

2

6

High-throughput

0.553

High

926869

VMAT1
Chromaffin granule amine transporter

2

2

High-throughput

0.553

High

1207652

F209A
Protein FAM209A

2

1

High-throughput

0.553

High

1214432

GORAB
RAB6-interacting golgin

2

1

High-throughput

0.553

High

1245856

TMED8
Protein TMED8

2

2

High-throughput

0.553

High

1248365

TM205
Transmembrane protein 205

2

1

High-throughput

0.553

High

1291527

RETR3
Reticulophagy regulator 3

2

1

High-throughput

0.553

High

1292562

AMGO1
Amphoterin-induced protein 1

2

2

High-throughput

0.553

High

1328822

TM86B
Lysoplasmalogenase TMEM86B

2

2

High-throughput

0.553

High

1349149

F174A
Membrane protein FAM174A

2

1

High-throughput

0.553

High

1352554

GPX8
Probable glutathione peroxidase 8

2

1

High-throughput

0.553

High

1359337

SSMM1
Serine-rich single-pass membrane protein 1

2

1

High-throughput

0.553

High

1388456

MTEF3
Transcription termination factor 3, mitochondrial

2

1

High-throughput

0.553

High

1409635

DHRS9
Dehydrogenase/reductase SDR family member 9

2

3

High-throughput

0.553

High

1417000

B2L13
Bcl-2-like protein 13

2

2

High-throughput

0.553

High

1429147

MFF
Mitochondrial fission factor

2

1

High-throughput

0.553

High

1449818

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

1460608

ERRFI
ERBB receptor feedback inhibitor 1

1

2

Small-scale

0.552

High

1331879

SYT2
Synaptotagmin-2

1

0

High-throughput

0.546

High

180105

BET1
BET1 homolog

1

14

High-throughput

0.536

High

483261

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

540754

LAMP1
Lysosome-associated membrane glycoprotein 1

1

11

High-throughput

0.536

High

984331

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

1092000

SEC20
Vesicle transport protein SEC20

1

5

High-throughput

0.536

High

1125948

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

1

High-throughput

0.536

High

1164366

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

1

High-throughput

0.536

High

1210133

SNP47
Synaptosomal-associated protein 47

1

1

High-throughput

0.536

High

1212971

STXB5
Syntaxin-binding protein 5

1

3

High-throughput

0.536

High

1219821

PLPP4
Phospholipid phosphatase 4

1

1

High-throughput

0.536

High

1399076

TMM74
Transmembrane protein 74

1

3

High-throughput

0.536

High

1452972

USE1
Vesicle transport protein USE1

1

3

High-throughput

0.536

High

1462327

TMM98
Transmembrane protein 98

1

1

High-throughput

0.536

High

193467

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

291713

XRP2
Protein XRP2

1

0

High-throughput

0.513

High

1007900

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

1314566

TM192
Transmembrane protein 192

1

0

High-throughput

0.513

High

1398813

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.513

High

1417286

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1454158

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.513

High

302098

SEGN
Secretagogin

1

3

High-throughput

0.489

High

923480

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

1

High-throughput

0.489

High

1316932

FAM9C
Protein FAM9C

1

5

High-throughput

0.489

High

1383514

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.489

High

1407134

MDFI
MyoD family inhibitor

1

1

High-throughput

0.489

High

386365

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.481

High

832659

AQP2
Aquaporin-2

1

14

Small-scale

0.481

High

1428522

ELOV4
Very long chain fatty acid elongase 4

1

8

High-throughput

0.481

High

218961

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

376097

RASK
GTPase KRas

1

12

High-throughput

0.479

High

390811

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

401700

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

466527

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

560557

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

562491

LAMP2
Lysosome-associated membrane glycoprotein 2

1

11

High-throughput

0.479

High

581374

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601499

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

620652

NUCL
Nucleolin

1

1

High-throughput

0.479

High

631563

RAB5A
Ras-related protein Rab-5A

1

12

High-throughput

0.479

High

901106

RAB5C
Ras-related protein Rab-5C

1

13

High-throughput

0.479

High

901678

RAB7A
Ras-related protein Rab-7a

1

16

High-throughput

0.479

High

953759

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955756

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962635

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

978406

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1015905

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1031599

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1065096

ITK
Tyrosine-protein kinase ITK/TSK

1

3

High-throughput

0.479

High

1091851

TP4A2
Protein tyrosine phosphatase type IVA 2

1

3

Small-scale

0.479

High

1111443

DGKZ
Diacylglycerol kinase zeta

1

2

High-throughput

0.479

High

1135540

RHG19
Rho GTPase-activating protein 19

1

2

High-throughput

0.479

High

1212628

HECD3
E3 ubiquitin-protein ligase HECTD3

1

2

Small-scale

0.479

High

1233579

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1271053

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1276372

ATG9A
Autophagy-related protein 9A

1

5

High-throughput

0.479

High

1286956

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1323044

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1334064

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1334627

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.479

High

1383174

LRC59
Leucine-rich repeat-containing protein 59

1

8

High-throughput

0.479

High

1404281

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1414505

DERL1
Derlin-1

1

2

High-throughput

0.479

High

1431589

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

4

High-throughput

0.479

High

1433580

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1436364

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1448853

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1454800

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

1461853

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

1462325

LAMP3
Lysosome-associated membrane glycoprotein 3

1

11

High-throughput

0.479

High

183982

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.460

High

1458891

CLN8
Protein CLN8

1

0

Small-scale

0.460

High

178443

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

564561

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.458

High

693134

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

896933

DYN2
Dynamin-2

1

0

High-throughput

0.458

High

1316322

NALCN
Sodium leak channel NALCN

1

0

High-throughput

0.458

High

1362017

RFFL
E3 ubiquitin-protein ligase rififylin

1

0

Small-scale

0.458

High

62067

WDR91
WD repeat-containing protein 91

1

2

High-throughput

0.457

High

800593

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.445

High

1034085

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

4

High-throughput

0.445

High

1251206

ZNT10
Calcium/manganese antiporter SLC30A10

1

13

High-throughput

0.445

High

1346732

SCAM5
Secretory carrier-associated membrane protein 5

1

4

Small-scale

0.445

High

1109095

AQP6
Aquaporin-6

1

15

High-throughput

0.439

High

1187603

AR13B
ADP-ribosylation factor-like protein 13B

1

5

High-throughput

0.439

High

1447179

S35C2
Solute carrier family 35 member C2

1

3

High-throughput

0.439

High

157989

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

583117

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.437

High

849048

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

1

Small-scale

0.437

High

1005244

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1186158

ANR55
Ankyrin repeat domain-containing protein 55

1

3

High-throughput

0.437

High

1207213

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

5

High-throughput

0.437

High

1214962

CCD18
Coiled-coil domain-containing protein 18

1

5

High-throughput

0.437

High

1227709

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.437

High

1293206

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

1431289

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1431792

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

1450137

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

1453927

TM216
Transmembrane protein 216

1

4

High-throughput

0.437

High

1454862

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

5

High-throughput

0.437

High

1459312

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1462324

CE164
Centrosomal protein of 164 kDa

1

3

High-throughput

0.437

High

943561

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

5

High-throughput

0.407

High

1131647

MFS10
Major facilitator superfamily domain-containing protein 10

1

4

High-throughput

0.407

High

1242271

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

1396589

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1108417

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.345

High

295896

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.328

High

1436652

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

1398155

JSPR1
Junctional sarcoplasmic reticulum protein 1

2

0

High-throughput

0.320

High

142117

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

885945

STAR
Steroidogenic acute regulatory protein, mitochondrial

2

0

High-throughput

0.316

High

1060311

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

0

High-throughput

0.316

High

1254321

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.316

High

1323250

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

1348801

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.316

High

1399665

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

2

0

High-throughput

0.316

High

1430840

STMN4
Stathmin-4

2

0

High-throughput

0.316

High

1437472

CERS4
Ceramide synthase 4

2

0

High-throughput

0.316

High

1462328

CIA30
Complex I intermediate-associated protein 30, mitochondrial

2

0

High-throughput

0.316

High

384581

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.279

Low

1004428

NOP14
Nucleolar protein 14

1

0

High-throughput

0.279

Low

1095961

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.279

Low

1250596

DPPA3
Developmental pluripotency-associated protein 3

1

0

High-throughput

0.279

Low

1272011

CENPQ
Centromere protein Q

1

0

High-throughput

0.279

Low

1389625

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1415335

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.279

Low

1418048

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.279

Low

1431407

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.279

Low

1449449

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

1462329

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.279

Low

1451140

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.269

Low

190029

TOX3
TOX high mobility group box family member 3

1

0

High-throughput

0.249

Low

1429475

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.249

Low

1310524

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025