HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0019899 - enzyme binding GO:0019901 - protein kinase binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 369
+	Hs
		228499 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MACD1_HUMAN (172-363): 9.08e-66: 213: 22.56
+	Hs
		228423 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H2A1A_HUMAN (1-128): 2.11e-65: 205: 61.83
+	Hs
		226333 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02
+	Hs
		227595 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28
+	Hs
		474911 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69
+	Sc
		392250 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		H2A2_YEAST (14-123): 1.54e-41: 144: 67.27
+	Zm
		45197 A0A1D6QJ03_MAIZE (265-456): 6.58e-58: 200: 22.80		B4FU52_MAIZE (14-117): 1.52e-41: 144: 71.15
+	Hs
		475312 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69
+	Hs
		476233 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1A_HUMAN (1-128): 2.11e-65: 205: 61.83
+	Hs
		476271 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50
+	Hs
		391519 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02
+	Hs
		475912 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57
+	Hs
		475833 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28