HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2602
+	Hs
		226513 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FLNA_HUMAN (1-2602): 0: 2661: 69.59
+	Hs
		227442 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FLNC_HUMAN (6-2602): 0: 1470: 35.38
+	Hs
		226387 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15
+	Hs
		227192 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65
+	Hs
		211433 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58
+	Hs
		228434 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HMCN1_HUMAN (664-2167): 2.48e-28: 128: 13.15
+	Hs
		475628 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PGBM_HUMAN (1199-2602): 3.08e-68: 259: 13.76
+	Hs
		476576 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69